Obtaining extremely large and accurate protein multiple sequence alignments from curated hierarchical alignments [PDF]
, 2020 Andrew F. Neuwald +3 more
openalex +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
MAGUS+eHMMs: improved multiple sequence alignment accuracy for fragmentary sequences. [PDF]
Bioinformatics, 2022 Shen C, Zaharias P, Warnow T.
europepmc +1 more source
Comparative analysis of seven multiple protein sequence alignment servers: clues to enhance reliability of predictions. [PDF]
, 1998 Pascal Briffeuil +6 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Accurate multiple sequence alignment of transmembrane proteins with PSI-Coffee
BMC Bioinformatics, 2012 Background Transmembrane proteins (TMPs) constitute about 20~30% of all protein coding genes. The relative lack of experimental structure has so far made it hard to develop specific alignment methods and the current state of the art (PRALINE™) only ...
Chang Jia-Ming +3 more
doaj +1 more source
ProPIP: a tool for progressive multiple sequence alignment with Poisson Indel Process. [PDF]
BMC Bioinformatics, 2021 Maiolo M +5 more
europepmc +1 more source
Recent developments in the MAFFT multiple sequence alignment program
Briefings Bioinform., 2008 K. Katoh, H. Toh
semanticscholar +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source