Results 41 to 50 of about 347,544 (289)

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source

Spinocerebellar Ataxia Type 2 [PDF]

, 2012
1. Introduction: The autosomal dominant cerebellar ataxias (ADCA) are a clinically, pathologically and genetically heterogeneous group of neurodegenerative disorders caused by degeneration of cerebellum and its afferent and efferent connections.
Auburger, Georg, Freund, Hans-Joachim, Rodríguez-Labrada, Roberto, Velázquez-Pérez, Luis   +3 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]

, 2019
The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto, Greco A., La Cava M, Lambiase A, Limoli PG, Nebbioso M   +5 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Apraxia and motor dysfunction in corticobasal syndrome [PDF]

, 2014
Background: Corticobasal syndrome (CBS) is characterized by multifaceted motor system dysfunction and cognitive disturbance; distinctive clinical features include limb apraxia and visuospatial dysfunction. Transcranial magnetic stimulation (TMS) has been
A Alberici, A Kertesz, A Kertesz, A Zwinkels, AA Kühn, AK Holl, Alessio Avenanti, B Borroni, B Okuda, BF Boeve, BF Boeve, BP Shelley, C Zadikoff, CD Good, D Claus, D Rueckert, DS Margulies, E De Renzi, E Frasson, E Mioshi, ED Huey, G Goldenberg, G Goldenberg, G Pengas, H Ling, J Ashburner, J Gottlieb, J Rohrer, J Valls-Solé, James R. Burrell, JL Whitwell, JM Cedarbaum, JO Rinne, John R. Hodges, JR Burrell, JR Burrell, JR Burrell, JR Burrell, K Tsuchiya, KA Josephs, KY Haaland, LJ Buxbaum, LJG Rothi, LR Robinson, M Heath, M Hornberger, M Pazzaglia, Matthew C. Kiernan, MC Kiernan, Michael Hornberger, NL Graham, NL Graham, P Soliveri, PK Pal, PP Pramstaller, PS Mathuranath, QJ Almeida, R Cantello, R Chen, R Leiguarda, R Leiguarda, R Mathew, R Mathew, RG Gross, RJ Fisher, RT Watson, S Vucic, S Vucic, S Vucic, S Vucic, SE Lee, SM Smith, SM Smith, Steve Vucic, T Fukui, U Ziemann, V Di Lazzaro, V Stamenova, Y Okuma, Y Zhang   +79 more
core   +7 more sources

Pareidolia in Parkinson’s Disease and Multiple System Atrophy

Parkinson's Disease, 2021
Pareidolia is a visual illusion of meaningful objects that arise from ambiguous forms embedded in visual scenes. Previous studies showed that pareidolias are frequently observed in patients with Parkinson’s disease (PD) as well as dementia with Lewy ...
Kentaro Kurumada, Atsuhiko Sugiyama, Shigeki Hirano, Tatsuya Yamamoto, Yoshitaka Yamanaka, Nobuyuki Araki, Masatsugu Yakiyama, Miki Yoshitake, Satoshi Kuwabara   +8 more
doaj   +1 more source

Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. [PDF]

, 2016
Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Baar, Keith, Baehr, Leslie M, Bodine, Sue C, De Sousa, Luis Gustavo, Marcotte, George, Marshall, Andrea G, West, Daniel WD   +6 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tremor in Multiple System Atrophy - a review

Tremor and Other Hyperkinetic Movements, 2013
Background: Multiple system atrophy (MSA) is a rare neurodegenerative movement disorder characterized by a rapidly progressive course. The clinical presentation can include autonomic failure, parkinsonism, and cerebellar signs.
Christine Kaindlstorfer, Roberta Granata, Gregor K. Wenning   +2 more
doaj   +1 more source