Results 81 to 90 of about 2,232,801 (311)

Pitfalls of statistical hypothesis testing: multiple testing [PDF]

BMJ, 2014
The effectiveness of a home based intervention on children’s body mass index (BMI) at age 2 years was investigated. A randomised controlled superiority trial was used. The intervention consisted of eight home visits from specially trained community nurses in the first 24 months after birth.
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Classification, Multiple Hypothesis Testing And Wavelet Thresholding Procedures With Applications

, 2006
[ITALIANO] Lo sviluppo delle metodologie statitistiche per l’analisi dati è generalmente collegato a progressi ottenuti in altri campi scientifici. Da un lato l’analisi statistica è spesso indirizzata a problemi reali, di conseguenza, il miglioramento ...
Cutillo, Luisa
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Flavor Quality Analysis of the High-Aroma Black Tea Cultivars ‘Jinmudan’ and ‘Jinguanyin’ Using Metabolomics [PDF]

Shipin Kexue
This study used widely targeted and targeted metabolomics based on headspace solid-phase microextraction combined with gas chromatography-mass spectrometry (HS-SPME-GC-MS) to analyze the non-volatile metabolites, volatile metabolites, and major quality ...
XU Mengting, GU Mengya, CHEN Jing, WEI Mingxiu, CHEN Qiang, WU Wenxi, ZHENG Yucheng, YE Naixing
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Predictive Models in Diagnosis of Alzheimer’s Disease from EEG

Acta Polytechnica, 2013
The fluctuation of an EEG signal is a useful symptom of EEG quasi-stationarity. Linear predictive models of three types and their prediction error are studied via traditional and robust measures.
Lucie Tylova, Jaromir Kukal, Oldrich Vysata   +2 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Multiple Dependent State Sampling Plan Based on Process Capability Index

, 2018
This paper extends the idea of multiple dependent state sampling plans to the case of using process capability index when the quality characteristic of the product follows the normal distribution. The plan parameters are determined using the optimization
Azam, M, Jun, CH, Aslam, M
core   +1 more source