Results 161 to 170 of about 25,229 (229)

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Advanced Science, Volume 13, Issue 19, 2 April 2026.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao, Jing Cai   +12 more
wiley   +1 more source

Murine Progeria Model Exhibits Delayed Fracture Healing With Senescent Phenotype and Dysregulated Immune Response

Journal of Orthopaedic Research, Volume 44, Issue 4, April 2026.
Graphical Abstract This study explores whether a murine model of progeria has a delayed fracture healing phenotype that resembles chronological aging but with an accelerated timeline that could make it a valuable research tool. ABSTRACT An estimated 189 million bone fractures occurred in 2019 making it one of the most globally prevalent injuries ...
Victoria R. Duke, Marc J. Philippon Jr., Dane R. G. Lind, Herbert Kasler, Kohei Yamaura, Matt Huard, Molly Czachor, Justin Hollenbeck, Justin Brown, Alex Garcia, Jacob D. Matityahu, Naomasa Fukase, Ralph S. Marcucio, Anna‐Laura Nelson, William S. Hambright, Dustin M. Snapper, Johnny Huard, Chelsea S. Bahney   +17 more
wiley   +1 more source

Chromosome 1 Open Reading Frame 35 Drives Colorectal Cancer Progression by Enhancing Tumor‐Intrinsic Proliferation and CD8+ T Cell Suppression

MedComm, Volume 7, Issue 4, April 2026.
This study identifies C1orf35 as a key driver of colorectal cancer progression through a dual mechanism. It promotes tumor‐intrinsic cell proliferation and migration via the c‐Myc/PYCR2 axis, and suppresses anti‐tumor immunity by impairing CD8+ T‐cell immune surveillance, nominating it as a novel therapeutic target in colorectal cancer.
Shaosen Zhang, Changjiang Yang, Xunye Xu, Lan Lan, Ziyi He, Jiaoting Chen, Caihong Wang   +6 more
wiley   +1 more source

Symbiosis‐associated UMAMIT transporters required for establishing efficient nitrogen fixation in Medicago truncatula

New Phytologist, Volume 250, Issue 1, Page 530-546, April 2026.
Summary To address a critical gap in understanding amino acid transport in legume–Rhizobium symbiosis, we investigated the role of symbiosis‐associated USUALLY MULTIPLE ACIDS MOVE IN AND OUT TRANSPORTERS (UMAMITs) in Medicago truncatula nodulation.
Courtney S. Winning, María Isabel Rubia, Wei Liu, Daniel Bronitt, Ángel María Zamarreño, José María García‐Mina, Penelope Smith, Estíbaliz Larrainzar, Michael A. Djordjevic   +8 more
wiley   +1 more source

Genetic Mapping and Functional Characterisation of GhCUP Regulating Leaf Curling in Cotton

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2607-2622, April 2026.
ABSTRACT Leaf size and shape are crucial traits affecting photosynthesis. Moderate leaf curling is believed to be beneficial to photosynthesis because upright leaves are ideal for building a canopy structure with reduced shaded areas to improve light penetration and ventilation.
Haonan Shi, Yanqing Qiao, Xiaohu Ma, Qian‐Hao Zhu, Haohong Tang, Yanlong Jin, Xuefeng Wang, Feng Liu, Jie Sun, Fei Xue   +9 more
wiley   +1 more source

Doppel as an early‐stage biomarker promoting EMT and dissemination in ovarian cancers

International Journal of Cancer, Volume 158, Issue 6, Page 1755-1768, 15 March 2026.
What's new? Existing biomarkers for ovarian cancer (OC) lack the sensitivity and specificity needed to consistently distinguish the malignancy from non‐ovarian influences and other cancers. Here, the authors explored the ability of the prion‐like protein Doppel, normally found in the male testes, to detect OC.
Zulfikar Azam, Xiaojun Zhang, Riajul Wahab, Md Mahedi Hasan, Shivaniben Dhadhal, Bowon Kang, Md Mynul Hassan, Mazharul Karim, Jeong Uk Choi, Muhit Rana, Jian‐Ying Zhang, Sourav Roy, Youngro Byun, In‐San Kim, Jae Yun Song, Eugene P. Toy, Sireesha Y. Reddy, Farzana Alam, Taslim A. Al‐Hilal   +18 more
wiley   +1 more source

Highly sensitive profiling somatic mutations of thyroid cancer by nucleotide-enrichment-based MALDI-TOF MS assay. [PDF]

Sci Rep
Bai H, Li Y, Li J, Liu T, Xiao J, Xia L, Sun X, Cheng W.   +7 more
europepmc   +1 more source

Diagnostic Methods for Bovine Coronavirus: A Review of Recent Advancements and Challenges. [PDF]

Viruses
Dong J, He X, Bao S, Wei Z.
europepmc   +1 more source