Results 21 to 30 of about 361 (249)

Toward integration of biological and physiological functions at multiple levels [PDF]

Frontiers in Physiology, 2010
An aim of systems physiology today can be stated as to establish logical and quantitative bridges between phenomenological attributes of physiological entities such as cells and organs and physical attributes of biological entities, i.e., biological molecules, allowing us to describe and better understand physiological functions in terms of underlying ...
openaire   +3 more sources

Asymptotic expansions of multiple integrals of rapidly oscillating functions [PDF]

Mathematics of Computation, 1988
Expansions of multiple integrals \[ ∫
Iwaniec, T., Lutoborski, A.
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Path integral for multiplicative noise: Generalized Fokker-Planck equation  and entropy production rate in stochastic processes with threshold

Physical Review Research
This paper introduces a comprehensive extension of the path-integral formalism to model stochastic processes with arbitrary multiplicative noise. To do so, the Itô diffusive process is generalized by incorporating a multiplicative noise term [η(t)] that ...
F. S. Abril-Bermúdez, C. J. Quimbay, J. E. Trinidad-Segovia, M. A. Sánchez-Granero   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Multiple valued functions and integral currents

ANNALI SCUOLA NORMALE SUPERIORE - CLASSE DI SCIENZE, 2015
We prove several results on Almgren's multiple valued functions and their links to integral currents. In particular, we give a simple proof of the fact that a Lipschitz multiple valued map naturally defines an integer rectifiable current; we derive explicit formulae for the boundary, the mass and the first variations along certain specific vector ...
Camillo De Lellis, Emanuele Spadaro.
openaire   +4 more sources

Stochastic integral representation of multiplicative operator functionals of a Wiener process

, 1972
Let M be a multiplicative operator functional of (X, L) where X is a d-dimensional Wiener process and L is a separable Hilbert space. Sufficient conditions are given in order that M be equivalent to a solution of the linear Itô equation \[
Mark A. Pinsky
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

On the almost sure running maxima of solutions of affine stochastic functional differential equations

, 2010
This paper studies the large fluctuations of solutions of scalar and finite-dimensional affine stochastic functional differential equations with finite memory as well as related nonlinear equations.
Wu, H., Appleby, John A.D., Mao, Xuerong
core   +1 more source