Results 101 to 110 of about 1,789 (148)
14‐3‐3ε conditional knockout mice exhibit defects in the development of the epidermis
FEBS Letters, Volume 598, Issue 24, Page 3005-3020, December 2024.A knockout of 14‐3‐3ε in the basal layer of the epidermis in mice leads to a decrease in proliferation and the thickness of the epidermis and decreased expression of differentiation markers. The knockout cells also show centrosome amplification, suggesting that centrosome amplification leads to decreased proliferation and subsequent thinning of the ...
Sarika Tilwani +2 more
wiley +1 more source
Advanced Science, Volume 11, Issue 46, December 11, 2024.This study focuses on the limited cold atmospheric plasma (CAP) penetration, a major challenge for its clinical application, in vivo and the results show the depth‐dependent biological effect of CAP treatment for the first time. Mitochondria damage and dysfunction induced by low dose CAP suppress microtubule assemble and spindle bipolar, and ultimately
Shengjie Peng +14 more
wiley +1 more source
PLoS ONE, 2011 Human Tubulin Binding Cofactor C (TBCC) is a post-chaperonin involved in the folding and assembly of α- and β-tubulin monomers leading to the release of productive tubulin heterodimers ready to polymerize into microtubules.
Ma Flor Garcia-Mayoral +5 more
doaj +1 more source
Extract of bulbus of Fritillaria cirrhosa induces spindle multipolarity in human-derived colonic epithelial NCM460 cells through promoting centrosome fragmentation [PDF]
, 2021 Xihan Guo +6 more
openalex +1 more source
A single psychotomimetic dose of ketamine decreases thalamocortical spindles and delta oscillations in the sedated rat [PDF]
arXiv, 2020 Background: In patients with psychotic disorders, sleep spindles are reduced, supporting the hypothesis that the thalamus and glutamate receptors play a crucial etio-pathophysiological role, whose underlying mechanisms remain unknown. We hypothesized that a reduced function of NMDA receptors is involved in the spindle deficit observed in schizophrenia.
arxiv
Notch Activation Is Associated with Tetraploidy and Enhanced Chromosomal Instability in Meningiomas
Neoplasia: An International Journal for Oncology Research, 2008 The Notch signaling cascade is deregulated in diverse cancer types. Specific Notch function in cancer is dependent on the cellular context, the particular homologs expressed, and cross-talk with other signaling pathways.
Gilson S. Baia +5 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2008 CHFR is an E3 ubiquitin ligase and an early mitotic checkpoint protein implicated in many cancers and in the maintenance of genomic stability. To analyze the role of CHFR in genomic stability, by siRNA, we decreased its expression in genomically stable ...
Lisa M. Privette +4 more
doaj +1 more source
Microcystin-LR and Cylindrospermopsin Induced Alterations in Chromatin Organization of Plant Cells
Marine Drugs, 2013 Cyanobacteria produce metabolites with diverse bioactivities, structures and pharmacological properties. The effects of microcystins (MCYs), a family of peptide type protein-phosphatase inhibitors and cylindrospermopsin (CYN), an alkaloid type of protein
Gábor Vasas +2 more
doaj +1 more source
Kinesin-5 motors are required for organization of spindle microtubules in
BMC Plant Biology, 2006 Background Monastrol, a chemical inhibitor specific to the Kinesin-5 family of motor proteins, was used to examine the functional roles of Kinesin-5 proteins during the first, asymmetric cell division cycle in the brown alga Silvetia compressa.
Kropf Darryl L, Peters Nick T
doaj +1 more source
Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.
PLoS Genetics, 2012 Disruption of the centromere protein J gene, CENPJ (CPAP, MCPH6, SCKL4), which is a highly conserved and ubiquitiously expressed centrosomal protein, has been associated with primary microcephaly and the microcephalic primordial dwarfism disorder Seckel ...
Rebecca E McIntyre +23 more
doaj +1 more source