Results 101 to 110 of about 153,409 (229)

PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage [PDF]

, 2015
PrimPol is a recently identified member of the archaeo-eukaryote primase (AEP) family of primase-polymerases. It has been shown that this mitochondrial and nuclear localised enzyme plays roles in the maintenance of both unperturbed replication fork ...
Aidan J. Doherty, Guo N, Helfrid Hochegger, Julie Bianchi, Laura J. Bailey, Nadia Hégarat, Ochs K, Zhang F   +7 more
core   +2 more sources

Choice between 1- and 2-furrow cytokinesis in Caenorhabditis elegans embryos with tripolar spindles

bioRxiv, 2018
Excess numbers of centrosomes often lead to multipolar spindles, and thus probably to multipolar mitosis and aneuploidy. In Caenorhabditis elegans, approximately 70% of the paternal emb-27APC6 mutant embryonic cells contained more than 2 centrosomes and ...
T. Kondo, A. Kimura
semanticscholar   +1 more source

Clinical and genetic landscape of epilepsies with absence seizures and single‐gene etiology

Epilepsia, EarlyView.
Abstract Objective To characterize the clinical, electroencephalographic, and genetic features of epilepsies featuring absence seizures within monogenic etiology, highlighting the diagnostic, treatment and prognostic implications. Methods We conducted a retrospective, multicenter study including patients with monogenic epilepsies and ...
Simona Balestrini, Ilaria Galli, Maria Luisa Ricci, Elena Parrini, Davide Mei, Mario Mastrangelo, Francesco Pisani, Corinna Filippi, Lucio Giordano, Elisabetta Cesaroni, Carla Marini, Emanuele Cerulli Irelli, Carlo di Bonaventura, Marica Rubino, Antonietta Coppola, Jacopo Proietti, Tommaso Lo Barco, Francesca Darra, Laura Licchetta, Francesca Bisulli, Marco Perulli, Domenica Battaglia, Angela De Dominicis, Marina Trivisano, Nicola Specchio, Roberta Solazzi, Davide Caputo, Laura Canafoglia, LICE Collaborative group, Carmen Barba, Emanuele Bartolini, Pia Bernardo, Maria Paola Canevini, Gaetano Cantalupo, Susanna Casellato, Mara Cavallin, Ilaria Contaldo, Alessandro Ferretti, Maria Luigia Gambardella, Tiziana Granata, Giuliana Lentini, Anna Luchetti, Federico Melani, Pasquale Parisi, Simona Pellacani, Laura Pietrangelo, Tiziana Pisano, Ilaria Onida, Emilia Ricci, Aglaia Vignoli, Renzo Guerrini   +50 more
wiley   +1 more source

Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer [PDF]

, 2016
Table S1. Patient characteristics. Table S2. Hazard ratios from multivariate analysis. Table S3. Sequences of primers used for qRT-PCR. Figure S1. Distribution of average centrosome number per cell in the breast cancer patients represented in our TMA ...
Beth A. Weaver, Craig Kanugh, Jennifer Laffin, Lauren M. Zasadil, Mark E. Burkard, Ryan A. Denu   +5 more
core   +2 more sources

The frequency and consequences of multipolar mitoses in undifferentiated embryonic stem cells.

Journal of Applied Biomedicine, 2019
Embryonic stem (ES) cells are pluripotent cells widely used in cell therapy and tissue engineering. However, the broader clinical applications of ES cells are limited by their genomic instability and karyotypic abnormalities.
V. Pospisilova, M. Ešner, Iveta Červenková, R. Fedr, J. Tinevez, A. Hampl, M. Anger   +6 more
semanticscholar   +1 more source

Abnormal cleavage patterns in equine in vitro‐produced embryos lead to higher early pregnancy loss

Equine Veterinary Journal, EarlyView.
Summary Background Despite significant advances, in vitro production (IVP) of equine embryos continues to lack standardised embryo classification criteria and is associated with increased rates of early pregnancy loss compared with in vivo‐derived blastocysts.
Soledad Martin‐Pelaez, Alejandro de la Fuente, Kazuki Takahashi, Hugo Monteiro, Mauricio Mendes, Stuart Meyers, Pouya Dini   +6 more
wiley   +1 more source

Phosphorylation of Targeting Protein for Xenopus Kinesin-like Protein 2 (TPX2) at Threonine 72 in Spindle Assembly [PDF]

The human ortholog of the targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a cytoskeletal protein that plays a major role in spindle assembly and is required for mitosis.
de Castro, IP, Neumayer, G, Nguyen, MD, Park, SK, Sanada, K, Shim, SY, Wang, J   +6 more
core   +1 more source

Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules [PDF]

, 2017
Tubulin-targeting molecules are widely used cancer therapeutic agents. They inhibit microtubule-based structures, including the mitotic spindle, ultimately preventing cell division.
Coluccia, Antonio, Cundari, Enrico, DI CESARE, Erica, Famiglini, Valeria, Giubettini, Maria, LA REGINA, Giuseppe, Lavia, Patrizia, Miele, Andrea, Rovella, Paola, Silvestri, Romano, Verrico, Annalisa   +10 more
core   +1 more source

Sinup is essential for the integrity of centrosomes and mitotic spindles in zebrafish embryos

Animal Cells and Systems, 2017
Fish lineage-specific gene, sinup [Siaz-interacting nuclear protein], modulates neural plate formation in embryogenesis and shares homology with human TPX2 protein, a member of the vertebrate mitogen-activating protein family. In spite of the presence of
Kyeong-Won Yoo, S. Maddirevula, Ajeet Kumar, Hyunju Ro, T. Huh, Myungchull Rhee   +5 more
semanticscholar   +1 more source

Cytoarchitecture and myeloarchitecture of the sheep auditory cortex

Journal of Anatomy, EarlyView.
This article describes the cyto‐ and myeloarchitecture of the sheep auditory cortex. It outlines a six‐layered cortical organization, with variations in cellular types and densities. The potential location of the primary auditory cortex is indicated by parvalbumin immunostaining.
Camille Pluchot, Mélody Morisse, Maryse Meurisse, Jean‐Marie Graïc, Elodie Chaillou, Scott A. Love   +5 more
wiley   +1 more source