Results 121 to 130 of about 153,409 (229)
Small Structures, Volume 7, Issue 1, January 2026.This article highlights the fibrous morphology of multiwalled carbon nanotubes as a key factor in their genotoxicity. Fibers physically interfere in cell division, generating binucleated cells and micronuclei, both of which are precursors of carcinogenesis.
Núria Pulido‐Artola +4 more
wiley +1 more source
BMC Cell Biology, 2003 Background Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But,
Hiraoka Yasushi +6 more
doaj +1 more source
Extract of bulbus ofFritillaria cirrhosainduces spindle multipolarity in human-derived colonic epithelial NCM460 cells through promoting centrosome fragmentation [PDF]
, 2021 Xihan Guo +6 more
openalex +1 more source
Mitotic spindle assembly by two different pathways in vitro [PDF]
, 1991 . We have used Xenopus egg extracts to study spindle morphogenesis in a cell-free system and have identified two pathways of spindle assembly in vitro using methods of fluorescent analogue cytochemistry.
Mitchison, T J, Sawin, K E
core +2 more sources
Lysine demethylase 4A: from chromatin to centrosomes
The FEBS Journal, Volume 293, Issue 2, Page 392-395, January 2026.The lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome.
Anushka Sharma +2 more
wiley +1 more source
Reprogramming within Hours Following Nuclear Transfer into Mouse but not Human Zygotes [PDF]
, 2013 Fertilized mouse zygotes can reprogram somatic cells to a pluripotent state. Human zygotes might therefore be useful for producing patient-derived pluripotent stem cells.
Acevedo, Nicole +13 more
core +1 more source
Advanced Science, Volume 12, Issue 45, December 4, 2025.To enable mitotic spindle assembly during cell division, centrosomes must bear tensile stresses generated by microtubule‐mediated pulling forces. Micro‐rheology reveals that PLK‐1 phosphorylation of the scaffold protein SPD‐5 tunes the viscoelasticity, size, and morphology of the centrosome scaffold in C. elegans.
Matthew Amato +5 more
wiley +1 more source
A SUMOylation Motif in Aurora-A: Implications in Spindle Dynamics and Oncogenesis
Frontiers in Oncology, 2011 Aurora-A is a serine/threonine kinase that plays critical roles in centrosome maturation, spindle dynamics and chromosome orientation and is frequently found overexpressed in human cancers.
Ignacio ePérez de Castro +8 more
doaj +1 more source
Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]
, 1996 In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M. +3 more
core +2 more sources
Sustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR [PDF]
, 2017 MicroRNA 26a (miR-26a) reduces cell viability in several cancers, indicating that miR-26a could be used as a therapeutic option in patients. We demonstrate that miR-26a not only inhibits G1-S cell cycle transition and promotes apoptosis, as previously ...
Adam E. Frampton +14 more
core +1 more source