Results 121 to 130 of about 1,789 (148)
Suppressing Anaphase-Promoting Complex/Cyclosome–Cell Division Cycle 20 Activity to Enhance the Effectiveness of Anti-Cancer Drugs That Induce Multipolar Mitotic Spindles [PDF]
Scott C. Schuyler +2 more
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Origin of the Cones of the Multipolar Spindle in Gladiolus [PDF]
Botanical Gazette, 1900 The above observations may be summarized as follows: As nuclear division approaches, a granular zone accumulates about the nucleus. This zone in every respect resembles the perikaryoplasm so characteristic of the pollen mother cells of Cobaea. A close network or felted zone of kinoplasmic fibers is formed immediately outside of and completely ...
ANSTRUTHER A. LAWSON
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Centrosomal amplification and spindle multipolarity in cancer cells
Seminars in Cancer Biology, 2004 Recent developments have highlighted the important role centrosomal defects play in the cellular changes associated with tumorigenesis. This article reviews recent developments addressing the impact of numerical centrosomal amplification on chromosomal segregational defects in the cancer cell.
William S. Saunders
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Spindle Multipolarity Is Prevented by Centrosomal Clustering
Science, 2005Most tumor cells are characterized by increased genomic instability and chromosome segregational defects, often associated with hyperamplification of the centrosome and the formation of multipolar spindles. However, extra centrosomes do not always lead to multipolarity.
William S. Saunders +4 more
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Induction of multipolar spindles by X-radiation in mammalian cells in vitro
Experimental Cell Research, 1963 Coverslip cultures of mammalian cells in logarithmic growth were exposed to 200, 400, and 600 r x radiation and fixed at 12-hr intervals up to 108 hr after exposure. The generation time of untreated cells was about 24 hr. Mitotic figures were scored and classed according to their number of poles at different intervals after irradiation.
A.G. Levis, G. Marin
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Depletion of CPAP by RNAi disrupts centrosome integrity and induces multipolar spindles
Biochemical and Biophysical Research Communications, 2005 We previously identified a novel microtubule-destabilizing motif in CPAP that can disassemble microtubules. To examine further the CPAP function in human cells, we used siRNA to knockdown its expression. Our results showed that CPAP depletion arrested cells in mitosis and induced apoptosis.
Jun‐Hung Cho +3 more
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Mitotic spindle multipolarity without centrosome amplification
Nature Cell Biology, 2014Mitotic spindle bipolarity is essential for faithful segregation of chromosomes during cell division. Multipolar spindles are often seen in human cancers and are usually associated with supernumerary centrosomes that result from centrosome overduplication or cytokinesis failure.
Helder Maiato, Elsa Logarinho
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Cellular Signalling, 2016 The protein-tyrosine kinase, c-Src, is involved in a variety of signaling events, including cell division. We have reported that v-Src, which is a mutant variant of the cellular proto-oncogene, c-Src, causes delocalization of Aurora B kinase, resulting in a furrow regression in cytokinesis and the generation of multinucleated cells. However, the effect
Keiko Kakae +5 more
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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2000 Role for microtubules in the induction of multiple microtubule organizing centers (MTOCs) and multipolar spindles by dimethylarsinic acid (DMAA), a methylated derivative of inorganic arsenics, was investigated with respect to the effects of microtubule disruption and reorganization.
Takafumi Ochi
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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2003 Dimethylarsine iodide (DMI) was used as a model compound of trivalent dimethylarsenicals [DMA(III)], and the biological effects were extensively investigated in cultured Chinese hamster V79 cells. When the cytotoxic effects of DMA(III) were compared with those of inorganic arsenite and dimethylarsinic acid [DMA(V)], DMA(III) was about 10,000 times more
Takafumi Ochi +5 more
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