Results 111 to 120 of about 37,255 (173)

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Phosphorylation disrupts the interaction between the intrinsically disordered region of the oncogenic NDRG1 and lipid vesicles

Protein Science, Volume 35, Issue 3, March 2026.
Abstract NDRG1 is a multifunctional regulatory human protein implicated in crucial cellular processes and acting as a central hub of a cancer‐related interactome. In lung cancer, increased NDRG1 expression is associated with resistance to chemotherapy and is linked to the cellular response to nickel, a known tumor driver in air pollution.
Noemi Carosella, Chiara Pastorello, Jehan Waeytens, Ylenia Beniamino, Valentina Roncassaglia, Lucrezia Serra, Vincent Raussens, Elisabetta Mileo, Stefano Ciurli, Barbara Zambelli   +9 more
wiley   +1 more source

Stepwise order in protein complex assembly: approaches and emerging themes

Open Biology
Protein-based nanomachines drive every cellular process. An explosion of high-resolution structures of multiprotein complexes has improved our understanding of what these machines look like and how they work, but we still know relatively little about how
Michael T. Brown, Michael A. McMurray
doaj   +1 more source

eMap 2.0: A Web‐Based Platform for Identifying electron Transfer Pathways in Proteins and Protein Families

WIREs Computational Molecular Science, Volume 16, Issue 2, March/April 2026.
In this review, we present eMap 2.0, a web‐based platform for analyzing electron transfer pathways in proteins. We highlight representative applications of eMap, including its use in characterizing electron transfer within individual proteins and in revealing shared electron transfer pathways across protein families.
James R. Gayvert, Alyssa J. Kranc, Ruslan N. Tazhigulov, Ksenia B. Bravaya   +3 more
wiley   +1 more source

Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists

WIREs RNA, Volume 17, Issue 2, March/April 2026.
U‐indel RNA editing targets mRNA:gRNA duplexes through three key complexes that collectively govern assembly, specificity, catalysis, and developmental regulation. Modern tools, including artificial intelligence, analyze the organization, dynamics, and evolution of the remarkable holo‐editosome, opening new avenues in RNA biology and therapy.
Suzanne M. McDermott, Julius Lukeš, Laurie K. Read, Reza Salavati, Achim Schnaufer, Sara L. Zimmer, Jason Carnes, Alasdair Ivens, Naghmeh Poorinmohammad, Nicholas J. Savill, Dave Speijer, Ken Stuart, Kristína Záhonová, Poorya Mirzavand Borujeni, Zihao Chen, Cody Goode, Sunil Kumar Sharma, Lars O’Hara, Jorge Cruz‐Reyes   +18 more
wiley   +1 more source

WDR72 Is Required for Urinary Acidification and Normal H+‐ATPase Activity in Intercalated Cells in Mice

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim Biallelic inactivating WDR72 variants are linked to distal renal tubular acidosis (dRTA), nephrocalcinosis, and amelogenesis imperfecta. The kidney shows high WDR72 expression; its precise localization and function remain unclear. WDR72 is a member of the WD40 repeat domain protein family—a large group of scaffold proteins involved in ...
Hannah Auwerx, Moana Busch‐Dohr, Xiaoxu Li, Carsten A. Wagner, Soline Bourgeois   +4 more
wiley   +1 more source

Deficiency of Tissue Nonspecific Alkaline Phosphatase Dysregulates Microglial Morphology and Function in a Mouse Model of Infantile Hypophosphatasia

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Using male and female tissue‐nonspecific alkaline phosphatase (TNAP) knockout (KO) and wild type (WT) mice, we show TNAP loss impairs growth and sensorimotor function and induces marked microglial morphological changes (enlarged soma, retracted processes).
Kareem Elaswad, Yara Mashal, Iyah Nasser, Linna Almhanaa, Chloe Grabowski, Zhi Zhang   +5 more
wiley   +1 more source

The environmentally responsive plant epigenome: insights from jasmonate signaling

New Phytologist, Volume 249, Issue 6, Page 2722-2728, March 2026.
Summary The environmental responsiveness of the plant epigenome is essential for spatiotemporally precise gene regulation, enabling plants to adapt to external cues. Elucidating the mechanisms underlying this responsiveness is therefore fundamental to deciphering the molecular logic of plant‐environment interactions.
Mark Zander, Emily Vesper
wiley   +1 more source

Reducing the Sinapine Levels of Camelina sativa Seeds Through Targeted Genome Editing of REF1

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1839-1865, March 2026.
ABSTRACT Sinapine (O‐sinapoyl choline) is the major phenolic metabolite typically found in the oil‐rich seeds of Brassicaceae such as Camelina sativa and Brassica napus. It imparts a bitter taste to the seeds as a defence mechanism against herbivores, but it also renders them less palatable to livestock.
Amélie A. Kelly, Martin Fulda, Merle Aden, Ilka N. Abreu, Kirstin Feussner, Ivo Feussner   +5 more
wiley   +1 more source

Polycystins as components of large multiprotein complexes of polycystin interactors. [PDF]

Cell Signal, 2020
Hardy E, Tsiokas L.
europepmc   +1 more source