Results 31 to 40 of about 37,255 (173)
Nuclear Coregulatory Complexes in Tregs as Targets to Promote Anticancer Immune Responses
Frontiers in Immunology, 2022 T-regulatory (Treg) cells display considerable heterogeneity in their responses to various cancers. The functional differences among this cell type are heavily influenced by multiprotein nuclear complexes that control their gene expression.
Lanette M. Christensen +2 more
doaj +1 more source
Lighting up multiprotein complexes: lessons from GPCR oligomerization [PDF]
Trends in Biotechnology, 2010 Spatiotemporal characterization of protein-protein interactions (PPIs) is essential in determining the molecular mechanisms of intracellular signaling processes. In this review, we discuss how new methodological strategies derived from non-invasive fluorescence- and luminescence-based approaches (FRET, BRET, BiFC and BiLC), when applied to the study of
Ciruela Alférez, Francisco +2 more
openaire +3 more sources
PLoS Pathogens, 2022 The hepatitis C virus (HCV) life cycle is highly regulated and characterized by a step-wise succession of interactions between viral and host cell proteins resulting in the assembly of macromolecular complexes, which catalyse genome replication and/or ...
Olaf Isken +5 more
doaj +1 more source
Microorganisms, 2020 The assembly of human cytomegalovirus (HCMV) virions is an orchestrated process that requires, as an essential prerequisite, the complex crosstalk between viral structural proteins. Currently, however, the mechanisms governing the successive steps in the
Yohann Couté +10 more
doaj +1 more source
Journal of Nucleic Acids, 2010 Nonhomologous end joining (NHEJ) plays a major role in double-strand break DNA repair, which involves a series of steps mediated by multiprotein complexes.
Takashi Ochi +5 more
doaj +1 more source
Microbiology Spectrum, 2022 The membrane-embedded injectisome, the structural component of the virulence-associated type III secretion system (T3SS), is used by Gram-negative bacterial pathogens to inject species-specific effector proteins into eukaryotic host cells.
Joshua R. Prindle +4 more
doaj +1 more source
The Scientific World Journal, 2019 Background. Many biological processes are performed by different protein complexes. During the association of proteins and enzymes forming specific complexes, the latter can include ions of various metal ions, which may be important for their formation ...
Svetlana E. Soboleva +2 more
doaj +1 more source
Controlled hierarchical assembly of switchable DNA–multiprotein complexes [PDF]
Biotechnology and Bioengineering, 2006 AbstractDirected, biologically‐driven self‐assembly has the potential to yield hybrid multicomponent architectures with applications ranging from sensors and diagnostics to catalysts and responsive materials. To enable these applications, it is critical to gain control over the precise orientation and geometry of biomolecules interacting with one ...
Grazyna E, Sroga, Jonathan S, Dordick
openaire +2 more sources
Cells, 2013 Contemporary quantitative mass spectrometry provides fascinating opportunities in defining the stoichiometry of high-molecular weight complexes or multiprotein platforms.
Inna Lavrik +3 more
doaj +1 more source
Polyomavirus T Antigens: Molecular Chaperones for Multiprotein Complexes [PDF]
Journal of Virology, 1998 Simian virus 40 (SV40) and murine polyomavirus (PyV) serve as powerful tools to identify key cellular regulatory proteins and to discern the mechanisms by which these proteins exert their biological effects. Like all members of the polyomavirus group, SV40 and PyV have simple genomes (Fig.
J L, Brodsky, J M, Pipas
openaire +2 more sources