Results 31 to 40 of about 19,858 (239)

Role of Stereochemistry on the Biological Activity of Nature-Inspired 3-Br-Acivicin Isomers and Derivatives

Molecules, 2023
Chiral natural compounds are often biosynthesized in an enantiomerically pure fashion, and stereochemistry plays a pivotal role in biological activity. Herein, we investigated the significance of chirality for nature-inspired 3-Br-acivicin (3-BA) and its
Andrea Galbiati, Aureliano Zana, Chiara Borsari, Marco Persico, Stefania Bova, Oleh Tkachuk, Alexandra Ioana Corfu, Lucia Tamborini, Nicoletta Basilico, Caterina Fattorusso, Stefano Bruno, Silvia Parapini, Paola Conti   +12 more
doaj   +1 more source

Nucleotide Sequence-Based Multitarget Identification [PDF]

Journal of Clinical Microbiology, 2003
ABSTRACTMULTIGEN technology (T. Vinayagamoorthy, U.S. patent 6,197,510, March 2001) is a modification of conventional sequencing technology that generates a single electropherogram consisting of short nucleotide sequences from a mixture of known DNA targets. The target sequences may be present on the same or different nucleic acid molecules.
T, Vinayagamoorthy, Kirk, Mulatz, Roger, Hodkinson   +2 more
openaire   +2 more sources

Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models

Frontiers in Nutrition, 2020
Cancer cachexia is a complex metabolic syndrome characterized by involuntary skeletal muscle loss and is associated with poor clinical outcome, decreased survival and negatively influences cancer therapy.
Wouter R. P. H. van de Worp, Annemie M. W. J. Schols, Jan Theys, Ardy van Helvoort, Ardy van Helvoort, Ramon C. J. Langen   +5 more
doaj   +1 more source

Beyond Antioxidant Effects: Nature-Based Templates Unveil New Strategies for Neurodegenerative Diseases

Antioxidants, 2021
The complex network of malfunctioning pathways occurring in the pathogenesis of neurodegenerative diseases (NDDs) represents a huge hurdle in the development of new effective drugs to be used in therapy.
Andrea Bacci, Massimiliano Runfola, Simona Sestito, Simona Rapposelli   +3 more
doaj   +1 more source

The Cuttlebone Blueprint for Multifunctional Metamaterials: Design Taxonomy, Functional Decoupling, and Future Horizons

Advanced Functional Materials, EarlyView.
Cuttlebone‐inspired metamaterials exploit a septum‐wall architecture to achieve excellent mechanical and functional properties. This review classifies existing designs into direct biomimetic, honeycomb‐type, and strut‐type architectures, summarizes governing design principles, and presents a decoupled design framework for interpreting multiphysical ...
Xinwei Li, Zhendong Li
wiley   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Multitarget magnetic activated cell sorter [PDF]

Proceedings of the National Academy of Sciences, 2008
Magnetic selection allows high-throughput sorting of target cells based on surface markers, and it is extensively used in biotechnology for a wide range of applications from in vitro diagnostics to cell-based therapies. However, existing methods can only perform separation based on a single parameter (i.e., the presence or absence of ...
Jonathan D, Adams, Unyoung, Kim, H Tom, Soh   +2 more
openaire   +2 more sources

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Multitarget Dielectrophoresis Activated Cell Sorter [PDF]

Analytical Chemistry, 2008
The ability to rapidly and efficiently isolate specific viruses, bacteria, or mammalian cells from complex mixtures lies at the heart of biomedical applications ranging from in vitro diagnostics to cell transplantation therapies. Unfortunately, many current selection methods for cell separation, such as magnetic activated cell sorting (MACS), only ...
Unyoung, Kim, Jiangrong, Qian, Sophia A, Kenrick, Patrick S, Daugherty, H Tom, Soh   +4 more
openaire   +2 more sources

Dehydrodieugenol Neolignans as Multitarget Anti-Inflammatory Agents: sPLA2 Inhibition and Therapeutic Implications

Drugs and Drug Candidates
Background/Objectives: The study investigated the anti-inflammatory potential of neolignan derivatives of dehydrodieugenol (CP1–CP5), focusing on the inhibition of secretory phospholipase A2 (sPLA2), a key enzyme in inflammation.
Adeilso B. Santos Junior, Caroline R. C. Costa, João H. G. Lago, Airam Roggero, Igor N. Oliveira, Danilo R. S. Lima, Paloma P. Borges, Willian H. B. C. Santos, Marcos A. Oliveira, Sérgio F. Sousa, Marcos H. Toyama   +10 more
doaj   +1 more source