Results 41 to 50 of about 19,858 (239)

Energy Consumption Optimization in Trajectory Planning for Fuel Cell Hybrid Uavs Based On HMPC

Advanced Robotics Research, EarlyView.
The endurance limitation of multirotor drones is a critical challenge. This study adopts a hybrid power system of fuel cells and lithium‐ion batteries. Using Nondominated Sorting Genetic Algorithm II, it integrates trajectory planning with energy management optimization.
Xindi Wang, Jianyang Dong, Yongming Yao, Kaijin Hu, Jianxiong Cui, Yikai Luo, Jiawen Zhang, Shichao Niu   +7 more
wiley   +1 more source

Amphetamine Derivatives as Potent Central Nervous System Multitarget SERT/NET/H₃ Agents: Synthesis and Biological Evaluation

Molecules
In this research, a variety of novel amphetamine derivatives were synthesized and assessed for their potential as multifaceted antidepressant agents.
Quxiang Li, Lili Ren, Dongli Wang, Junyong Luo, Changda Xu, Jian Feng, Yufan Qiu, Xiangqing Xu, Guoguang Chen   +8 more
doaj   +1 more source

An AI‐Enabled All‐In‐One Visual, Proximity, and Tactile Perception Multimodal Sensor

Advanced Robotics Research, EarlyView.
Targeting integrated multimodal perception of robots, an AI‐enabled all‐in‐one multimodal sensor is proposed. This sensor is capable of perceiving three types of modalities, including vision, proximity, and tactility. By toggling an ultraviolet light and adjusting the camera focus, it switches smoothly between multiple perceptual modalities, enabling ...
Menghao Pu, Tiyong Zhao, Lingxi Zhang, Chaoqun Han, Zhiping Chai, Yifan Zhou, Han Ding, Zhigang Wu   +7 more
wiley   +1 more source

Multitarget Drug Discovery and Polypharmacology [PDF]

ChemMedChem, 2016
Promising promiscuity: Guest editors Maria Laura Bolognesi and Andrea Cavalli set the stage for this ChemMedChem Special Issue on Polypharmacology and Multitarget Drugs. They highlight cases in which a departure from the "one target, one drug" paradigm has proven advantageous, with single molecules that can engage two or more targets to address a given
BOLOGNESI, MARIA LAURA, CAVALLI, ANDREA
openaire   +3 more sources

Tandem CAR-T cell therapy: recent advances and current challenges

Frontiers in Immunology
CAR-T cell therapy has revolutionized cancer treatment. However, despite the achievements of this approach, there are still clinical challenges to address, such as antigen loss and the design of an optimal CAR structure.
Sara Gómez-Melero, Sara Gómez-Melero, Fakhri Hassouneh, Isabel M. Vallejo-Bermúdez, Eduardo Agüera-Morales, Eduardo Agüera-Morales, Rafael Solana, Javier Caballero-Villarraso, Javier Caballero-Villarraso, Javier Caballero-Villarraso   +9 more
doaj   +1 more source

Multitarget Molecular Hybrids of Cinnamic Acids

Molecules, 2014
In an attempt to synthesize potential new multitarget agents, 11 novel hybrids incorporating cinnamic acids and paracetamol, 4-/7-hydroxycoumarin, benzocaine, p-aminophenol and m-aminophenol were synthesized.
Aikaterini Peperidou, Dorothea Kapoukranidou, Christos Kontogiorgis, Dimitra Hadjipavlou-Litina   +3 more
doaj   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Screening of Multitarget Compounds against Acetaminophen Hepatic Toxicity Using In Silico, In Vitro, and In Vivo Approaches

Molecules
Combination therapy and multitarget drugs have recently attracted much attention as promising tools to fight against many challenging diseases and, thus, represent a new research focus area.
Muhammad Ali, Esha Asghar, Waqas Ali, Ghulam Mustafa, Irfan Aamer Ansari, Saadiya Zia, Siddique Akber Ansari, Sumaiya Khan   +7 more
doaj   +1 more source

EDTA‐Functionalized Nanoscale Metal–Organic Framework for Onco‐Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation

Advanced Science, EarlyView.
Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan, Liyang Tian, Luwen Zhuang, Yongyu Liang, Lingfei Chen, Xuetao Wang, Yanli Li, Xiyong Yu, Teng Gong   +8 more
wiley   +1 more source