Results 11 to 20 of about 13,574 (319)
The Innovation, 2023 The multivalency of bioligands in living systems brings inspiration for not only the discovery of biological mechanisms but also the design of extracellular matrix (ECM)-mimicking biomaterials.
Xu Chen +8 more
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Multivalent Aptamer Approach: Designs, Strategies, and Applications
Micromachines, 2022 Aptamers are short and single-stranded DNA or RNA molecules with highly programmable structures that give them the ability to interact specifically with a large variety of targets, including proteins, cells, and small molecules.
Zhong Wang +3 more
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Oligosaccharide Ligands of Galectin-4 and Its Subunits: Multivalency Scores Highly
Molecules, 2023 Galectins are carbohydrate-binding lectins that modulate the proliferation, apoptosis, adhesion, or migration of cells by cross-linking glycans on cell membranes or extracellular matrix components.
Kristýna Slámová +6 more
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Frontiers in Immunology, 2023 Vaccines are among the most cost-effective public health measures for controlling infectious diseases. Coxiella burnetii is the etiological agent of Q fever, a disease with a wide clinical spectrum that ranges from mild symptoms, such as fever and ...
Sharon Jan +12 more
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Beilstein Journal of Organic Chemistry, 2021 The synthesis of a sulfate-modified dendritic peptide amphiphile and its self-assembly into one-dimensional rod-like architectures in aqueous medium is reported.
David Straßburger +5 more
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Multivalent Carbonic Anhydrases Inhibitors [PDF]
International Journal of Molecular Sciences, 2019 Biomolecular recognition using a multivalent strategy has been successfully applied, this last decade on several biological targets, especially carbohydrate-processing enzymes, proteases, and phosphorylases. This strategy is based on the fact that multivalent interactions of several inhibitory binding units grafted on a presentation platform may ...
Fabrizio Carta +3 more
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Molecules, 2020 Biology is dominated by polyanions (cell membranes, nucleic acids, and polysaccharides just to name a few), and achieving selective recognition between biological polyanions and synthetic systems currently constitutes a major challenge in many biomedical
Domenico Marson +4 more
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Natural Sciences, 2022 Preface by Prof. Titia de Lange, Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA The 19th Annual Wiley Prize in Biomedical Sciences celebrated a breakthrough in cell biology: how membrane‐less cellular ...
Clifford Brangwynne +2 more
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ChemistryOpen, 2020 In the study of multivalent interactions at interfaces, as occur for example at cell membranes, the density of the ligands or receptors displayed at the interface plays a pivotal role, affecting both the overall binding affinities and the valencies ...
Dr. Daniele Di Iorio +1 more
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Counting Degrons: Lessons From Multivalent Substrates for Targeted Protein Degradation
Frontiers in Physiology, 2022 E3s comprise a structurally diverse group of at least 800 members, most of which target multiple substrates through specific and regulated protein-protein interactions.
Cynthia N. Okoye +3 more
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