Results 161 to 170 of about 24,310,597 (280)

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus

open access: yesAdvanced Science, EarlyView.
Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto   +5 more
wiley   +1 more source

Bayesian lightweight emulators for multivariate computer models

open access: yes, 2011
Statistical emulators for the outputs of complex computer codes (simulators) are typically constructed using nonparametric regression methods, such as Gaussian Process (GP) regression. For many simulators, emulators based on parametric models may provide
Woods, David C., Overstall, Antony M.
core  

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

open access: yesAdvanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang   +19 more
wiley   +1 more source

Discriminant analysis of multivariate time series using wavelets [PDF]

open access: yes
In analyzing ECG data, the main aim is to differentiate between the signal patterns of those of healthy subjects and those of individuals with specific heart conditions.
M. Andrés Alonso, Ann Elizabeth Maharaj
core  

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