Results 51 to 60 of about 231,548 (297)

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Intact, recombinant, and spliced forms of endogenous mouse mammary tumor viruses in inbred and wild mice

Journal of Virology
Endogenous retroviruses (ERVs) are chromosomally integrated viral copies that represent relics of past infections. Analysis of the sequenced genomes of 17 mouse strains, Mus musculus subspecies, and Mus spretus identified 29 ERVs of mouse mammary tumor ...
Oscar Lam, Esther Shaffer, Guney Boso, Christine A. Kozak   +3 more
doaj   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Avaliação da patogenicidade decorrente da infecção pelo Schistosoma mansoni Sambon, 1907, agente de infecções unissexuais em Mus musculus Assessment of pathogenic effects of infection with Schistosoma mansoni Sambon, 1907, agent of unisexual infection in Mus musculus

Revista de Saúde Pública, 1983
Estudou-se em camundongos de laboratório, aspectos da patogenicidade decorrentes de infecções unissexuais e bissexuais produzidas por S. mansoni. Verificou-se quantitativamente a deposição de ovos nas fezes, da 1ª a 8ª semana após a infecção.
Eliana Maria Zanotti, Luiz Augusto Magalhães, Aquiles Eugenico Piedrabuena   +2 more
doaj   +1 more source

DOPAMAP, high-resolution images of dopamine 1 and 2 receptor expression in developing and adult mouse brains

Scientific Data, 2022
Measurement(s) mRNA expression Technology Type(s) transgenic Mouse • immunohistochemistry staining method Sample Characteristic - Organism Mus ...
I. E. Bjerke, E. R. Cullity, K. Kjelsberg, K. M. Charan, T. B. Leergaard, J. H. Kim   +5 more
doaj   +1 more source

Pathogen Detection in Ornithodoros sonrai Ticks and Invasive House Mice Mus musculus domesticus in Senegal

Microorganisms, 2022
Ornithodoros sonrai (O. sonrai) ticks are the only known vectors of Borrelia crocidurae, an agent of tick-borne relapsing fever (TBRF) borreliosis. Rodents serve as principal natural reservoirs for Borrelia.
Basma Ouarti, Moussa Sall, El Hadji Ibrahima Ndiaye, Georges Diatta, Adama Zan Diarra, Jean Michel Berenger, Cheikh Sokhna, Laurent Granjon, Jean Le Fur, Philippe Parola   +9 more
doaj   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Localização de Schistosoma mansoni no plexo porta de Mus musculus experimentalmente infectados por um só sexo do trematódeo Localization of Schistosoma mansoni in the portal system of Mus musculus infected experimentally by a single sex of the trematode

Revista de Saúde Pública, 1982
Foi estudado o hábito migratório de Schistosoma mansoni em infecções bissexuais e nas produzidas por um só sexo do trematódeo, tendo sido evidenciada a influência do sexo no deslocamento dos esquistossomos.
Eliana Maria Zanotti, Luiz Augusto Magalhães, Aquiles Eugenico Piedrabuena   +2 more
doaj   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Nine-day continuous recording of EEG and 2-hour of high-density EEG under chronic sleep restriction in mice

Scientific Data, 2022
Measurement(s) electroencephalography (EEG) Technology Type(s) electroencephalography (EEG) Factor Type(s) Chronic sleep restriction Sample Characteristic - Organism Mus ...
Hio-Been Han, Bowon Kim, Youngsoo Kim, Yong Jeong, Jee Hyun Choi   +4 more
doaj   +1 more source