Results 111 to 120 of about 57,597 (217)

Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control

The Journal of Physiology, EarlyView.
Richard J. A. Wilson, Nicholas Jendzjowsky   +1 more
wiley   +1 more source

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Bronchodilator Responsiveness in Preterm‐Born Children With Chronic Lung Disease: Importance of Individualized Testing

Pediatric Pulmonology, Volume 61, Issue 7, July 2026.
ABSTRACT Background Children born preterm with chronic lung disease of Immaturity (CLDI) frequently present with obstructive lung function, yet optimal bronchodilator therapy remains uncertain. Previous studies focused on β2‐agonists, while evidence for muscarinic antagonist therapy is limited.
Yotam Ophir, Jana Tukova
wiley   +1 more source

An Age‐Friendly Approach to Caring for Chronic Lung Disease in the Ambulatory Setting

Respirology, Volume 31, Issue 7, Page 676-692, July 2026.
ABSTRACT Many common chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD), have much greater prevalence among older adults and as a result, pose a substantial burden of morbidity, disability, and mortality. The care of older adults with chronic lung disease necessitates an age‐friendly approach
Angela O. Suen, Lauren R. Pollack, C. Adrian Austin, Leah J. Witt   +3 more
wiley   +1 more source

Spexin disrupts migrating myoelectric complex in the rat small intestine: The role of galanin-2 and muscarinic receptors. [PDF]

Pflugers Arch
Saltık ÖD, Balcı H, Abdullahoğlu R, Bozkurt A.   +3 more
europepmc   +1 more source

Unprecedented Synthesis of a Terminal Dialkynyl Primary Carbinamine: A Bioinspired Lipid With Cytotoxic Activities

ChemistrySelect, Volume 11, Issue 27, 17 July 2026.
This study reports the first synthesis of a bioinspired lipid featuring a terminal dialkynyl primary carbinamine moiety. The target compound was obtained via an N‐Boc ynaldimine intermediate, derived from the pentadec‐2‐ynal in four steps. It exhibited promising activity against three different cancer cell lines (IC50 2–5 µM), with good selectivity (5 ...
François‐Xavier Toublet, Abdelhak Lachguar, Mohamed Salem, Bastien Dumais, Sébastien Britton, Nadège Preuilh, Stéphanie Ballereau, Yves Génisson, Valérie Maraval, Pr. Vania Bernardes‐Génisson   +9 more
wiley   +1 more source

Efficacy and safety of the muscarinic receptor agonist KarXT (Xanomeline-Trospium) in schizophrenia: a systematic review, meta-analysis and Bayesian sensitivity analysis. [PDF]

Int J Neuropsychopharmacol
Sharma N, Khatib MN, R R, Kaur M, Srivastava M, Barwal A, Prasad GVS, Rajput P, Mittal V, Shabil M, Kumar A, Bushi G, Mehta R, Satapathy P, Sah S.   +14 more
europepmc   +1 more source

Prehospital Use of Non‐Invasive Ventilation for Acute Respiratory Failure due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease. A Randomised Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background In‐hospital use of non‐invasive ventilation improves outcomes in patients with acute respiratory failure caused by acute exacerbation of chronic obstructive pulmonary disease. Prehospital use of non‐invasive ventilation is uncommon due to diagnostic uncertainty and logistical constraints.
Jesper H. Brendel, Lars W. Andersen, Søren H. Skaarup, Thomas Dissing, Anders Gunnar Nielsen, Nikolaj F. Milandt, Ulrick S. Espelund, Lisa F. Irion, Lone R. Mortensen, Kim M. Larsen, Jens Aage K. Petersen   +10 more
wiley   +1 more source

Chemogenetic Stimulation of the Dorsal Motor Nucleus of the Vagus Mitigates Autonomic Dysfunction and Memory Decline in Rat Model of Alzheimer‐Like Disease

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Aim To test the hypothesis that Alzheimer‐like metabolic neurodegeneration rat model leads to an autonomic dysfunction, memory impairment, and hippocampal amyloid pathology and that long‐term chemogenetic stimulation of the dorsal motor nucleus of the vagus reverses these alterations. Methods Male and female transgenic Long Evans rats received
Beatriz Pacheco Sousa, Karoline Martins dos Santos, Vagner Roberto Antunes   +2 more
wiley   +1 more source