Results 191 to 200 of about 113,768 (249)
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Annual Review of Pharmacology and Toxicology, 1990
In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine receptors: Muscarinic receptors are selectively activated by muscarine and blocked by atropine; nicotinic receptors are activated by nicotine and blocked by curare.
E C, Hulme, N J, Birdsall, N J, Buckley
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In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine receptors: Muscarinic receptors are selectively activated by muscarine and blocked by atropine; nicotinic receptors are activated by nicotine and blocked by curare.
E C, Hulme, N J, Birdsall, N J, Buckley
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The use of muscarinic toxins in the study of muscarinic receptors
Life Sciences, 1997One of the most interesting recent developments in the pharmacology of muscarinic receptors has been the finding of small proteins in the venoms of mamba snakes that bind with high affinity and selectivity to different subtypes of muscarinic receptors. In the workshop on muscarinic toxins, the practicalities of isolating, characterising and using these
Diana Jerusalinsky +3 more
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Muscarinic synapses in the hypothalamus
American Journal of Physiology-Legacy Content, 1962It has been reported that drinking may be selectively induced by direct application of cholinergic crystalline substances (carbachol, acetylcholine capped with physostigmine) into the hypothalamus. We confirmed and extended this finding by demonstrating that this central cholinergic effect was based on a muscarinic, and not a nicotinic, action. Minute
L, STEIN, J, SEIFTER
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Muscarine in Clitocybe Species
Journal of Pharmaceutical Sciences, 1968Results of chemical and bioassays for muscarine in a sample of Clitocybe dealbata indicate the absence of other muscarine-like substances or muscarine potentiators. Evidence was found for the presence of muscarine in herbarium samples of C. illudens, C. cerussata, C. dealbata , and C. rivulosa . The age of samples ranged from 12 to 26 years.
K, Genest, D W, Hughes, W B, Rice
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Desensitization of Muscarinic Receptors
Receptors and Channels, 2004When Chinese hamster ovary cells transfected with the gene for M(3)-muscarinic receptors were stimulated with carbachol continuously for 30 min, the response at the end of the stimulation period was about 20% of the early response (2-3 min after the start of the stimulation).
N, Fraeyman +3 more
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Muscarinic Receptors in Schizophrenia
Current Molecular Medicine, 2003An increasing body of evidence suggests that the muscarinic receptors may present a potential therapeutic target for the treatment of schizophrenia. This argument is supported by studies using postmortem CNS tissue and a neuroimaging study that have shown there are regionally specific decreases in selective muscarinic receptors in the CNS of subjects ...
B, Dean, F P, Bymaster, E, Scarr
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Calcium and the muscarinic receptor
General Pharmacology: The Vascular System, 1976Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response.
M K, Ticku, D J, Triggle
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Muscarinic binding in suicides
Psychiatry Research, 1984Supersensitive muscarinic cholinergic receptors may underlie mood, neuroendocrine, and sleep disturbances in depression. To test this hypothesis, we examined muscarinic binding sites in the brains of suicides and controls in a matched-pair design, using the radioligand 3H-quinuclidinyl benzilate (QNB) and focusing on regions (frontal cortex ...
C A, Kaufmann +6 more
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Muscarinic receptors in pineal
Life Sciences, 1980Abstract The presence of muscarinic receptors in sheep and rat pineals was detected by binding of [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB), a potent and specific muscarinic antagonist. [ 3 H]QNB binding to sheep pineal membrane resuspensions was saturable and reversible, with a rate constant for association at 37°C of 6×10 8 M −1 min −1 and a rate ...
R L, Taylor, M L, Albuquerque, D R, Burt
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MUSCARINIC RECEPTOR DIFFERENTIATION
Clinical and Experimental Pharmacology and Physiology, 1989SUMMARY1. Several selective antagonists are available to differentiate between muscarinic receptors.2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors.3. Reasons for differences between affinity constants determined in functional and binding studies and whether receptor subtypes ...
F, Mitchelson, L K, Choo, S, Darroch
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