Results 181 to 190 of about 82,903 (289)

Muscarinic Receptor PET in Neurodegeneration: Promise, Pitfalls, and Translational Priorities. [PDF]

Med Sci (Basel)
Filippi L, Danieli R.
europepmc   +1 more source

Translational PBPK Modeling and Exposure‐Response Analysis of AT‐RvD1 for Treating Sjögren's Disease

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Sjögren's disease (SD) is an autoimmune condition characterized by chronic inflammation and impaired secretory function of the salivary glands (SG). The proresolving lipid mediator AT‐RvD1 restores SG function in SD‐like mice; however, its tissue pharmacokinetics, exposure‐response relationships, and human dose predictions remain poorly ...
Venkata K. Yellepeddi, Kihoon Nam, Frank M. Maslow, Olga J. Baker   +3 more
wiley   +1 more source

Updates in COPD Management: From Inflammatory Pathways to Targeted Therapies

European Journal of Clinical Investigation, Volume 56, Issue 10, October 2026.
COPD is a heterogeneous disease driven by overlapping neutrophilic and eosinophilic inflammatory pathways. This review highlights the shift from symptom‐based treatment toward phenotype‐ and biomarker‐directed care. Blood eosinophils, FeNO, and IgE predict corticosteroid responsiveness and identify candidates for biologic therapy.
Sasha Raman, Sreya Rahman, Francesca Polverino, Muhammad Adrish   +3 more
wiley   +1 more source

Role of Muscarinic Receptor Signaling Processes in Specific Aspects of Morphine-Induced Respiratory Depression in Rats. [PDF]

Pharmaceuticals (Basel)
Getsy PM, May WJ, Baby SM, Coffee GA, Qiu Y, Cheng F, Bates JN, Lewis SJ.   +7 more
europepmc   +1 more source

Enhanced mucosal contractile activity following rapid, reversible inhibition of bladder activity by dimethyl sulfoxide (DMSO). [PDF]

World J Urol
Katugampola L, Falk E, Moro C, Sellers DJ, Chapple CR, Chess-Williams R.   +5 more
europepmc   +1 more source

Characterizing short‐term linear and nonlinear heart rate variability in typically developing children and adolescents

Physiological Reports, Volume 14, Issue 19, October 2026.
Nonlinear heart rate variability differed by age and sex in typically developing youth. Nonlinear measures were associated with parasympathetic indices. Figure generated in Biorender. Abstract Linear heart rate variability (HRV) quantifies heart rate (HR) changes due to stochastic processes while nonlinear HRV captures the complexity of the HR ...
Alexs A. Matias, Michele N. D'Agata, Krista M. Szymanski, Evan C. Ciecko, Melissa A. Witman   +4 more
wiley   +1 more source

Toward a Pluralistic Model for the Schizophrenia Spectrum-Dopamine and Beyond. [PDF]

JAMA Psychiatry
Keshavan MS, Nasrallah HA, Abi-Dargham A, Grace AA, Javitt DC, Lewis DA, Marder SR, Meyer JM, Murray RM, Öngür D, Stahl SM, Tandon R.   +11 more
europepmc   +1 more source

Influence of exogenous glucagon‐like peptide 2 on mechanisms of enteric neurotransmitter‐mediated vasorelaxation in the isolated bovine mesenteric artery and vein

Physiological Reports, Volume 14, Issue 19, October 2026.
Abstract Exogenous glucagon‐like peptide 2 (GLP‐2) administration increases small intestinal growth and mesenteric blood flow, although the vascular mechanisms involved remain unclear. The objective of this study was to characterize the effects of exogenous GLP‐2 administration on glucagon‐like peptide 2 (GLP‐2)‐, vasoactive intestinal peptide (VIP ...
Gabriel S. S. David, Erica C. Maples, James L. Klotz, Ronald J. Trotta   +3 more
wiley   +1 more source

Emerging non-D₂ receptor-based therapies for schizophrenia: a focus on muscarinic and glutamatergic pathways. [PDF]

Front Psychiatry
Wang Y, Wang J, Zhang X, Liu X.
europepmc   +1 more source