Results 171 to 180 of about 57,597 (217)

Targeting disrupted networks in schizophrenia: Can muscarinic drugs make a fundamental difference? [PDF]

J Psychopharmacol
Pratt JA, Morris BJ.
europepmc   +1 more source

A pragmatic, multicentre, placebo-controlled, 3-arm, double-blinded, randomised controlled trial, incorporating an internal pilot, to determine the role of bronchodilators in preventing exacerbations of bronchiectasis.

Health Technol Assess
Wilson N, Morton M, Homer T, Breeze Konkoth A, Joyce R, Kershaw A, Wilde H, Liddle A, Wason J, Ternent L, Allen M, Lord R, Steer J, Devereux G, Chalmers JD, Hill AT, Haworth CS, Hurst JR, De Soyza AA.   +18 more
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Muscarinic toxins

Toxicon, 2011
Muscarinic toxins isolated from the venom of Dendroaspis snakes may interact with a high affinity, large selectivity and various functional properties with muscarinic receptors. Therefore, these toxins are invaluable tools for studying the physiological role, molecular functioning and structural organization of the five subtypes of these G-Protein ...
Servent, Denis, Blanchet, Guillaume, Mourier, Gilles, Marquer, Catherine, Marcon, Elodie, Fruchart-Gaillard, Carole   +5 more
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Structures of muscarine picrate and muscarine tetraphenylborate

Acta Crystallographica Section C Crystal Structure Communications, 1993
The tetrahydrofuran ring of the muscarine ion [(±)-(2S,4R,5S)-tetrahydro-4-hydroxy-N, N,N,5-tetramethyl-2-furanaminium] of muscarine picrate, as well as that of muscarine tetraphenylborate, is observed in a distorted twist conformation, 4 T 3 . This is different from the conformation observed in the crystal structure of muscarine chloride, but nearly ...
K. Frydenvang, B. Jensen
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Muscarinic Receptor Subtypes

Annual Review of Pharmacology and Toxicology, 1990
In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine receptors: Muscarinic receptors are selectively activated by muscarine and blocked by atropine; nicotinic receptors are activated by nicotine and blocked by curare.
E C, Hulme, N J, Birdsall, N J, Buckley
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The use of muscarinic toxins in the study of muscarinic receptors

Life Sciences, 1997
One of the most interesting recent developments in the pharmacology of muscarinic receptors has been the finding of small proteins in the venoms of mamba snakes that bind with high affinity and selectivity to different subtypes of muscarinic receptors. In the workshop on muscarinic toxins, the practicalities of isolating, characterising and using these
Diana Jerusalinsky, Alan Harvey, Evert Karlsson, Lincoln Potter   +3 more
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