Results 151 to 160 of about 113,768 (249)

The dual-site agonist for human M2 muscarinic receptors Iper-8-naphtalimide induces mitochondrial dysfunction in <i>Saccharomyces cerevisiae</i>. [PDF]

Microb Cell
Cirigliano A, Amelina A, Passarini E, Ricelli A, Balasco N, Mori M, Botta B, De Stefano ME, Papotto C, Guerriero C, Tata AM, Rinaldi T.   +11 more
europepmc   +1 more source

The Effect of the Anticonvulsant Topiramate on Acetylcholine‐Induced Calcium Signals is Linked to Sirt‐1 Activity

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
This work provides a potential new link between the anticonvulsive Topiramate, the deacetylase Sirt‐1 and the cholinergic signalling, suggesting that Topiramate may modulate cholinergic pathways in a Sirt‐1 depended manner. ABSTRACT Although some forms of epilepsy directly result from mutations in nicotinic acetylcholine receptors, none of the ...
Marie‐Luise Kümmel
wiley   +1 more source

Distinct Neuronal Activation in the Paraventricular Nucleus of the Hypothalamus Accompanies Baroreflex Impairment and Elevated Cardiac Sympathetic Tone in Salt‐Loaded Rats

European Journal of Neuroscience, Volume 63, Issue 10, May 2026.
This study investigated an animal model of short‐term high‐salt exposure (2% NaCl) for 7 days and its effects on baroreflex function, cardiac autonomic balance, and the pattern of paraventricular nucleus of the hypothalamus (PVH) neuronal activation during a baroreflex loading. High salt intake leads to an increase in blood pressure (BP) and heart rate
Angelo Bernak de Oliveira, Pedro Sousa Soares, Paula Magalhães Gomes, Vagner Roberto Antunes   +3 more
wiley   +1 more source

Pharmacological and light-driven pupillary accommodation in guinea pigs: comparative effects of muscarinic modulators and illumination across developmental stages. [PDF]

Int J Ophthalmol
Wu H, Lu N, Qiao ZB, Cheng C, Luo WT, Wan T, Qiao T, Di Y.   +7 more
europepmc   +1 more source

Association Between Cholinesterase Inhibitor‐Overactive Bladder Antimuscarinic Prescribing Cascade and Risk of Delirium and Falls Among Individuals Living With Dementia

Journal of the American Geriatrics Society, Volume 74, Issue 5, Page 1314-1325, May 2026.
ABSTRACT Background Prescribing cascades occur when cholinesterase inhibitor (ChEI)‐induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI‐OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older
Sarah Beth Tucker, Bryan L. Love, Chijioke M. Okeke, Erin D. Zwick, Chengwen Teng, Jingkai Wei, Ibraheem M. Karaye, Saud Alsahali, Krithika Rajagopalan, Ismaeel Yunusa   +9 more
wiley   +1 more source

Adjunctive xanomeline/trospium in clozapine-resistant schizophrenia: two case reports demonstrating limited response. [PDF]

Ther Adv Psychopharmacol
Dang VM, Powers JM, Markota M, Leung JG.
europepmc   +1 more source

Dualsteric Agonist for M2 Muscarinic Receptor Causes Oxidative Stress and Mitochondrial Alteration in Human Glioblastoma Cancer Stem Cells

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Dualsteric agonist N8‐iper shows cytotoxic effects on glioblastoma cancer stem cells, but not on human normal astrocytes. Lipid accumulation appears as a consequence of cytotoxic stress; in fact, they are not present in healthy astrocytes. ABSTRACT Glioblastoma (GB) is the most malignant form of human brain tumor, characterized by heterogeneous cell ...
Claudia Guerriero, Chiara De Nuccio, Maria Petrone, Teresa Rinaldi, Angela Cirigliano, Sergio Visentin, Antonietta Bernardo, Luciano Conti, Carlo Matera, Marco De Amici, Clelia Dallanoce, Ada Maria Tata   +11 more
wiley   +1 more source

Anxiolytic and antidepressant effects of astaxanthin: behavioral and mechanistic insights in a rat model. [PDF]

Front Pharmacol
Ranjbari M, Fakhri S, Abbaszadeh F, Kiani A, Mohammadi-Noori E, Echeverría J.   +5 more
europepmc   +1 more source