Results 141 to 150 of about 113,768 (249)

Severe organophosphate intoxication without classic cholinergic signs: A case report and updated literature review. [PDF]

Sci Prog
Naghizade U, Sabo V, Renfer N, Schmid S, Müller M, Schilling T.   +5 more
europepmc   +1 more source

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, Volume 183, Issue 9, Page 2123-2138, May 2026.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

A complex interplay of various intracellular motifs determines G protein binding and activation of muscarinic receptors. [PDF]

Sci Rep
Kirchhofer SB, Jelinek V, Klingelhöfer K, Krett AL, Bünemann M.   +4 more
europepmc   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, Volume 183, Issue 10, Page 2360-2375, May 2026.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

The risk factors of future exacerbations and treatment responses among different inhalation therapies of patients with preserved ratio impaired spirometry. [PDF]

J Glob Health
Cao J, Sun T, Yang H, Zhou L, Shen Q, Lin L, Li T, Zhang P, Zeng Y, Chen P, Song Q, Lei S, Li J.   +12 more
europepmc   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Bidirectional Modulation of Beam Traversal Performance by Acetylcholine in the Cerebellar Nuclei. [PDF]

J Neurosci
Iosif CI, Drake RAR, Apps R, Bashir ZI, Pickford J.   +4 more
europepmc   +1 more source

The effect of inhaled dry salt on pulmonary mucociliary clearance in obstructive lung disease: A randomised, placebo‐controlled, crossover study

Clinical Physiology and Functional Imaging, Volume 46, Issue 3, May 2026.
Abstract Background Inhaled saline may improve mucus transport in respiratory diseases, for example, cystic fibrosis. This randomised, placebo‐controlled, crossover study examined the effect of inhaled dry NaCl on mucociliary clearance in patients with chronic obstructive pulmonary disease (COPD). Methods Twenty‐five patients with GOLD stage I‐III COPD
Rie Skovly Thomsen, Clara Mikkelsen, Naja Enevold Olsen, Hrefna Sæunn Einarsdóttir, Mohamed Attauabi, Ronan M. G. Berg, Henrik Harboe, Jann Mortensen   +7 more
wiley   +1 more source

Role of autonomic receptors in ethyl ferulate-induced cardiovascular effects in normotensive and hypertensive female rats. [PDF]

Pflugers Arch
de S Nunes FV, Araujo SSP, da Silva JA, de Assunção JGV, de Oliveira AA, Dourado CER, de O Damasceno V, de Oliveira AP, Martins MDCC, de Morais MC, de Sousa DP, de Queiroz TM, Soriano RN, Branco LGS, Salgado HC, Sabino JPJ.   +15 more
europepmc   +1 more source

A Scoping Review of Non‐Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Sara L. Mills‐Huffnagle, Oliver M. Lowden, Rhea E. Sullivan, Taryn E. McFadden, Jennifer E. Nyland   +4 more
wiley   +1 more source