The Clinical Characteristic and Prognostic Value of Frailty in Elderly COPD Patients
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.ABSTRACT Background and Objective Frailty, as one of the extrapulmonary comorbidities of chronic obstructive pulmonary disease (COPD), is highly prevalent in COPD patients. The primary objective of this research was to assess how frailty influences subsequent exacerbation and augments the predictive capacity of dyspnoea or the exacerbation history ...
Tao Li +6 more
wiley +1 more source
Chronic High-Fat Diet Downregulates M3 Muscarinic and β1-Adrenergic Receptor mRNA Expression and Alters Submandibular Gland Histology in Wistar Rats. [PDF]
Diabetes Metab Syndr ObesFitria D +4 more
europepmc +1 more source
Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management
MedComm, Volume 7, Issue 10, October 2026.A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley +1 more source
Improvements With Tiotropium Maintenance Therapy in COPD Patients Without Dyspnea
MedComm, Volume 7, Issue 10, October 2026.In a post hoc analysis of the Tie‐COPD trial, including 305 patients with mild‐to‐moderate COPD and no dyspnea (mMRC 0), 2 years of tiotropium improved lung function, lowered the annual exacerbation rate, and delayed the first clinically important deterioration, indicating benefit beyond symptom relief in a group not currently offered maintenance ...
Zihui Wang +15 more
wiley +1 more source
MedComm, Volume 7, Issue 10, October 2026.Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang +5 more
wiley +1 more source
Xanomeline and Trospium Chloride: Mechanism of Action, Clinical, and Translational Science. [PDF]
Clin Transl SciAvila S, Chen IL.
europepmc +1 more source
Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies
MedComm, Volume 7, Issue 10, October 2026.The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao +7 more
wiley +1 more source
Treatment-resistant Parkinson's disease psychosis responding to xanomeline-trospium: A case report. [PDF]
Clin Park Relat DisordFarah A, Timbrook-Dillow K, Garrison H.
europepmc +1 more source
Allergy, Volume 81, Issue 10, Page 3439-3452, October 2026.ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque +5 more
wiley +1 more source
Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor
The M1 muscarinic acetylcholine receptor (M1R) is highly expressed in the nervous system, and has been studied to discover new therapeutic drugs for a range of neurological and psychiatric disorders.
Amiri, Shayan
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