Results 111 to 120 of about 29,139 (279)

Endothelial TRPV4–Cx43 signalling complex regulates vasomotor tone in resistance arteries

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In this study, we investigate, for the first time, the role of endothelial Cx43 hemichannels (hCx43) in the regulation of vasomotor tone. We discovered that TRPV4 channels and Cx43 are in proximity within the endothelium of mouse arterioles.
Pía C. Burboa   +7 more
wiley   +1 more source

Chemogenetic Control of Striatal Astrocytes Improves Parkinsonian Motor Deficits in Mice

open access: yesGlia, Volume 73, Issue 6, Page 1188-1202, June 2025.
Main Points Dopamine depletion reduces locomotion‐induced calcium activity in dorsal striatal astrocytes. Chemogenetic activation facilitates astrocyte locomotion responses and improves motor behavior in dopamine lesioned animals. ABSTRACT Parkinson's disease (PD) is characterized by the degeneration of dopaminergic nigrostriatal inputs, which causes ...
Wesley R. Evans   +7 more
wiley   +1 more source

European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management

open access: yesUnited European Gastroenterology Journal, Volume 13, Issue 3, Page 427-471, April 2025.
ABSTRACT Introduction Chronic nausea and vomiting are symptoms of a wide range of gastrointestinal and non‐gastrointestinal conditions. Diagnosis can be challenging and requires a systematic and well‐structured approach. If the initial investigation for structural, toxic and metabolic disorders is negative, digestive motility and gut‐brain interaction ...
Carolina Malagelada   +34 more
wiley   +1 more source

Selective M3 Muscarinic Receptor Antagonist Inhibits Small-Cell Lung Carcinoma Growth in a Mouse Orthotopic Xenograft Model

open access: yesJournal of Pharmacological Sciences, 2011
.: In small cell lung carcinoma (SCLC), acetylcholine (ACh) is synthesized and secreted, and it acts as an autocrine growth factor through activation of its receptors, muscarinic receptor (mAChR) and nicotinic receptor (nAChR). Alteration of tumor growth
Nozomi Ami   +5 more
doaj  

Toll‐like receptor 4 deficiency ameliorates experimental ileitis and enteric neuropathy: Involvement of nitrergic and 5‐hydroxytryptaminergic neurotransmission

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 8, Page 1803-1822, April 2025.
Abstract Background and Purpose Inflammatory bowel disease (IBD) patients display genetic polymorphisms in toll‐like receptor 4 (TLR4) genes, contributing to dysregulate enteric nervous system (ENS) circuits with increased levels of 5‐HT and alteration of the neuroimmune crosstalk.
Sofia Faggin   +12 more
wiley   +1 more source

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