Results 111 to 120 of about 53,107 (259)
Cholinergic Regulation of Orexin/Hypocretin Neurons Through M3Muscarinic Receptor in Mice
Journal of Pharmacological Sciences, 2008 The cholinergic system plays an important role in regulation of arousal and REM sleep. In the present study, we showed that a muscarinic receptor agonist, carbachol (CCh), activates almost 20% of orexin-producing neurons (orexin neurons), which play a ...
Kousaku Ohno +2 more
doaj
Opening a hydrophobic gate: the nicotinic acetylcholine receptor as an example [PDF]
arXiv, 2009 To what extent must a hydrophobic gate expand for the channel to count as open? We address this question using the nicotinic acetylcholine receptor (nAChR) as the exemplar. The nAChR is an integral membrane protein which forms a cation selective channel gated by neurotransmitter binding to its extracellular domain.
arxiv
Internal Medicine Journal, EarlyView.Abstract Hyperhidrosis is an under‐reported and under‐treated condition that causes significant patient morbidity. Secondary causes require consideration, but the vast majority of cases are idiopathic. The condition is encountered by a range of clinicians, including neurologists, dermatologists and endocrinologists, and it pays to be familiar with the ...
Mitchell J. Lycett, Karl Ng
wiley +1 more source
The human colon: Evidence for degenerative changes during aging and the physiological consequences
Neurogastroenterology &Motility, EarlyView.Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source
Slow synaptic transmission in frog sympathetic ganglia [PDF]
, 1986 Bullfrog ganglia contain two classes of neurone, B and C cells, which receive different inputs and exhibit different slow synaptic potentials. B cells, to which most effort has been directed, possess slow and late slow EPSPs.
Adams, P. R. +5 more
core +2 more sources
The mechanisms of calcium homeostasis and signalling in the lens [PDF]
, 2008 Excessive Ca2+ can be detrimental to cells and raised levels of Ca2+ in human lenses with cortical cataract have been found to play a major role in the opacification process.
Rhodes, JD, Sanderson, J
core +1 more source
Frontiers in Neuroscience, 2018 The muscarinic acetylcholine type 1 receptor (M1R) is a metabotropic G protein-coupled receptor. Knockout of M1R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse ...
Mohammad G. Sabbir +3 more
doaj +1 more source
Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction
Neurogastroenterology &Motility, EarlyView.Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley +1 more source
The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation [PDF]
, 2005 Background— The molecular mechanism of increased background inward rectifier current (IK1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active acetylcholine (ACh)-activated IK,ACh contributes to enhanced basal ...
Christ, T. +7 more
core +1 more source
Decoding Gastric Reflexes: The Role of Mechanosensitive Enteric Neurons in Stomach Motility
Neurogastroenterology &Motility, EarlyView.ABSTRACT This review focuses on mechanosensitive enteric neurons (MEN) in the guinea pig stomach and their roles in gastric motor reflex pathways. The guinea pig model is advantageous for studying gastric physiology, as its stomach structure and function closely resemble those of humans. Gastric motility involves distinct functional regions: the fundus
Gemma Mazzuoli‐Weber +2 more
wiley +1 more source