Results 111 to 120 of about 54,620 (293)

Assessment of Novel Muscarinic Acetylcholine Receptors in Rat Cerebral Cortex by a Tissue Segment Binding Method

Journal of Pharmacological Sciences, 2010
Muscarinic acetylcholine receptors (mAChRs) of rat cerebral cortex were evaluated using a tissue segment radioligand binding assay. [3H]-Quinuclidinyl benzilate (QNB, a hydrophobic ligand) specifically bound to mAChRs in the cortex segments.
Kung-Shing Lee, Atsushi Nishimune, Hatsumi Yoshiki, Abu Syed Md Anisuzzaman, Fumiko Suzuki, Mao-Hsien Wang, Juei-Tang Cheng, Ikunobu Muramatsu   +7 more
doaj   +1 more source

Activation of nematode G protein GOA‐1 by the human muscarinic acetylcholine receptor M₂ subtype [PDF]

, 2006
Masaomi Minaba, Susumu Ichiyama, Katsura Kojima, Mamiko Ozaki, Yusuke Kato   +4 more
openalex   +1 more source

Spirocyclic Diamine Scaffolds for Medicinal Chemistry

Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.
Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel, Alejandro Flores, Maedeh Darsaraee, Jean‐Louis Reymond   +3 more
wiley   +1 more source

Functional Activation of G-Proteins Coupled With Muscarinic Acetylcholine Receptors in Rat Brain Membranes

Journal of Pharmacological Sciences, 2014
.: The functional activation of Gi/o proteins coupled to muscarinic acetylcholine receptors (mAChRs) was investigated with the conventional guanosine-5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding assay in rat brain membranes.
Yuji Odagaki, Masakazu Kinoshita, Ryoichi Toyoshima   +2 more
doaj   +1 more source

Protection from interferon‐β‐induced neuronal apoptosis through stimulation of muscarinic acetylcholine receptors coupled to ERK1/2 activation [PDF]

, 2016
Maria C. Olianas, Simona Dedoni, Pierluigi Onali   +2 more
openalex   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, Volume 46, Issue 1, Page 179-197, January 2026.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of Pharmacological Sciences, 2011
.: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada, Hidetada Matsuoka, Takeyoshi Sata, Akira Warashina, Masumi Inoue   +4 more
doaj   +1 more source

M1 muscarinic acetylcholine receptor‐mediated inhibition of GABA release from striatal medium spiny neurons onto cholinergic interneurons [PDF]

, 2020
Etsuko Suzuki, Toshihiko Momiyama
openalex   +1 more source

Pharmacotherapeutic Controversies During Temperature Control After Out‐of‐Hospital Cardiac Arrest: A Semi‐Structured Literature Review

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 1, January 2026.
ABSTRACT Post‐resuscitation cardiac arrest care begins at the time of hospital admission and focuses on preventing the sequelae of ischemia–reperfusion injury, including secondary brain damage and post‐cardiac arrest syndrome. Clinical practice guidelines on post‐resuscitation cardiac arrest care from international medical organizations outline ...
Christy Cecil Forehand, Scott Thomas Benken, Melanie Madorsky, Adham Mohamed, Jerika V. Nguyễn, Deepali Dixit, Jolie Gallagher, William Anthony Hawkins, Mojdeh Saba Heavner, Emory Johnson, Lauren Lozano, Melanie Sisco, Angela A. Slampak‐Cindric, Susan Elizabeth Smith, Katherine Spezzano, Bayard Angel Taylor II, Nathaniel Brett Wayne, David John Gagnon   +17 more
wiley   +1 more source

Molecular Conversion of Muscarinic Acetylcholine Receptor M5 to Muscarinic Toxin 7 (MT7)-Binding Protein

Toxins, 2011
Muscarinic toxin 7 (MT7) is a mamba venom peptide that binds selectively to the M1 muscarinic acetylcholine receptor. We have previously shown that the second (ECL2) and third (ECL3) extracellular loops of the M1 receptor are critically involved in ...
Katja Näreoja, Johnny Näsman, Sergio Rondinelli   +2 more
doaj   +1 more source