Muscarinic acetylcholine receptors (mAChRs) of rat cerebral cortex were evaluated using a tissue segment radioligand binding assay. [3H]-Quinuclidinyl benzilate (QNB, a hydrophobic ligand) specifically bound to mAChRs in the cortex segments.
Kung-Shing Lee+7 more
doaj
Targeting the M1 muscarinic acetylcholine receptor in Alzheimer's disease. [PDF]
Dwomoh L, Tejeda GS, Tobin AB.
europepmc +1 more source
Agonist‐induced Transfer of the α Subunits of the Guanine‐nucleotide‐binding Regulatory Proteins Gq and G11, and of Muscarinic m1 Acetylcholine Receptors from Plasma Membranes to a Light‐vesicular Membrane Fraction [PDF]
Petr Svoboda, Graeme Milligan
openalex +1 more source
Acetylcholine autoexcites the release of proopiomelanocortin-derived peptides from melanotrope cells of Xenopus laevis via an M1 muscarinic receptor. [PDF]
F. J. Van Strien+3 more
openalex +2 more sources
.: The functional activation of Gi/o proteins coupled to muscarinic acetylcholine receptors (mAChRs) was investigated with the conventional guanosine-5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding assay in rat brain membranes.
Yuji Odagaki+2 more
doaj
Pharmacological Profiling of a Brugia malayi Muscarinic Acetylcholine Receptor as a Putative Antiparasitic Target. [PDF]
Gallo KJ+4 more
europepmc +1 more source
The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation. [PDF]
Duan J+6 more
europepmc +1 more source
Vagus nerve stimulation as a modulator of feedforward and feedback neural transmission [PDF]
Vagus nerve stimulation (VNS) has emerged as a promising therapeutic intervention across various neurological and psychiatric conditions, including epilepsy, depression, and stroke rehabilitation; however, its mechanisms of action on neural circuits remain incompletely understood.
arxiv
Current optimization of combined therapy for chronic obstructive pulmonary disease
Testing the new combined bronchodilator Anoro Ellipta in different clinical trials gives proof to its high clinical efficacy and safety in chronic obstructive pulmonary disease.
E N Popova
doaj