Results 181 to 190 of about 7,723 (245)

Elevation of Ligand Binding to Muscarinic M2 Acetylcholine Receptors by Bis(ammonio)alkane-Type Allosteric Modulators

open access: green, 2002
Alexandra Raasch   +4 more
openalex   +1 more source

Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)

open access: hybrid
Julie L. Engers   +17 more
openalex   +1 more source

Muscarinic acetylcholine receptors and airway diseases

open access: yesPharmacology & Therapeutics, 2003
Parasympathetic nerves provide the dominant autonomic innervation of the airways. Release of acetylcholine from parasympathetic nerves activates postjunctional muscarinic receptors present on airway smooth muscle, submucosal glands, and blood vessels to cause bronchoconstriction, mucus secretion, and vasodilatation, respectively.
Coulson, Fiona R., Fryer, Allison D.
openaire   +6 more sources

The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation [PDF]

open access: yesJournal of Investigative Dermatology, 2022
The M3 muscarinic acetylcholine receptor is predominantly expressed in the basal epidermal layer where it mediates the effects of the autocrine/paracrine cytotransmitter acetylcholine.
Junyan Duan   +2 more
exaly   +2 more sources

Muscarinic acetylcholine receptor

Progress in Neurobiology, 1978
ABSTRACT Muscarinic acetylcholine receptors from rat cerebral cortex and small intestine were studied by the high affinity and high specific activity antagonists 3 H-3-quinuclidinyl benzilate (3-QNB) (29.4 Ci/mmol) and 3 H-N-methyl-4-piperidinyl benzilate (4-NMPB) (55.4 Ci/mmol).
E, Heilbronn, T, Bartfai
openaire   +3 more sources

Muscarinic Acetylcholine Receptors

Current Pharmaceutical Design, 2006
Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate cascade leading to intracellular ...
Masaru, Ishii, Yoshihisa, Kurachi
openaire   +2 more sources

Primary structure of porcine muscarinic acetylcholine receptor III and antagonist binding studies

open access: yesFEBS Letters, 1988
The complete amino acid sequence of porcine muscarinic acetylcholine receptor III has been deduced by cloning and sequencing the genomic DNA. The antagonist binding properties of muscarinic acetylcholine receptor III expressed from the cloned DNA in ...
Tai Kubo, Akito Maeda, Junichi Nakai
exaly   +2 more sources

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