Results 181 to 190 of about 54,223 (288)

Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust <i>In Vivo</i> Efficacy. [PDF]

ACS Chem Neurosci
Gregro AR, Park C, Long MF, Baker LA, Bollinger KA, Ringuette AE, Peng L, Luscombe VB, Billard NB, Rodriguez AL, Niswender CM, Peng W, Dickerson JW, Rook JM, O'Neill J, Chang S, Boonen HCM, Jensen T, Thomsen MS, Bridges TM, Boutaud O, Conn PJ, Engers DW, Lindsley CW, Temple KJ.   +24 more
europepmc   +1 more source

Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking. [PDF]

Int J Mol Sci, 2023
Wang D, Yao Y, Wang S, Hou Y, Zhao L, Wang H, Chen H, Xu J.   +7 more
europepmc   +1 more source

Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice

, 2011
Lene S. Schmidt, Morgane Thomsen, Pia Weikop, Ditte Dencker, Jürgen Wess, David P.D. Woldbye, Gitta Wörtwein, Anders Fink‐Jensen   +7 more
openalex   +2 more sources

Weight Gain With Advancing Age Is Controlled by the Muscarinic Acetylcholine Receptor M4 in Male Mice. [PDF]

Endocrinology
Takahashi T, Takase Y, Shiraishi A, Matsubara S, Watanabe T, Kirimoto S, Yamagaki T, Osawa M.   +7 more
europepmc   +1 more source

Clinical and Preclinical Evidence for M₁ Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome. [PDF]

Neurotherapeutics, 2022
Smith M, Arthur B, Cikowski J, Holt C, Gonzalez S, Fisher NM, Vermudez SAD, Lindsley CW, Niswender CM, Gogliotti RG.   +9 more
europepmc   +1 more source

Activation and allosteric modulation of a muscarinic acetylcholine receptor [PDF]

, 2013
Andrew C. Kruse, Aaron M. Ring, Aashish Manglik, Jianxin Hu, Kelly Hu, Katrin Eitel, Harald Hübner, Els Pardon, Céline Valant, Patrick M. Sexton, Arthur Christopoulos, Christian C. Felder, Peter Gmeiner, Jan Steyaert, William I. Weis, K. Christopher García, Jürgen Wess, Brian K. Kobilka   +17 more
openalex   +1 more source

Muscarinic Acetylcholine Receptor M1 [PDF]

, 2020
openaire   +1 more source

Design, Synthesis, and Evaluation of a New Fluorescent Ligand for the M₂ Muscarinic Acetylcholine Receptor. [PDF]

ACS Med Chem Lett
Szabó R, Szepesi Kovács D, Kiss DJ, Yazdi ZN, Tóth AD, Brea J, Loza MI, Meszéna D, Wittner L, Ulbert I, Volk B, Hunyady L, Keserű GM.   +12 more
europepmc   +1 more source

New Tricks for an Old Dog: Biased GPCR Agonism of an M4 Muscarinic Acetylcholine Receptor Antagonist in Airway Smooth Muscle Cells. [PDF]

Am J Respir Cell Mol Biol, 2022
Amrani Y.
europepmc   +1 more source

Identification of Candidate Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor Which May Improve Vagus Nerve Stimulation in Chronic Tinnitus [PDF]

, 2017
Tijana Bojić, Vladimir Perović, Milan Senćanski, Sanja Glišić   +3 more
openalex   +1 more source