Results 201 to 210 of about 7,723 (245)

Constitutive Activity of Muscarinic Acetylcholine Receptors

Journal of Receptors and Signal Transduction, 2006
We review the literature describing constitutive activity of the five muscarinic acetylcholine receptors in native and recombinant systems and discuss the effect of constitutive activity on muscarinic pharmacology in the context of modern models of receptor activation.
Tracy A, Spalding, Ethan S, Burstein
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Molecular Biology of Muscarinic Acetylcholine Receptors

Critical Reviews™ in Neurobiology, 1996
Following the molecular cloning of five distinct muscarinic acetylcholine receptor (mAChR) genes, the last decade has witnessed an explosion of new knowledge about how mAChRs function at a molecular level. These studies have been greatly facilitated by the molecular characterization of the many components of the signal transduction pathways activated ...
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Muscarinic acetylcholine receptors of rat lymphocytes

Biochimica et Biophysica Acta (BBA) - General Subjects, 1983
The muscarinic acetylcholine receptors on rat lymphocytes were determined by [3H]quinuclidinyl benzilate binding studies. Binding of [3H]quinuclidinyl benzilate is rapid (half saturation occurred within 120 s) and highly specific. Muscarinic receptors reveal high lability. The number of receptors on plasma membrane depends on time of incubation as well
W, Maśliński, K, Krzystyniak, E, Grabczewska, J, Ryzewski   +3 more
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Regulation of muscarinic acetylcholine receptor signaling

Pharmacology & Therapeutics, 2003
Multiple mechanisms regulate the signaling of the five members of the family of the guanine nucleotide binding protein (G protein)-coupled muscarinic acetylcholine (ACh) receptors (mAChRs). Following activation by classical or allosteric agonists, mAChRs can be phosphorylated by a variety of receptor kinases and second messenger-regulated kinases.
Chris J, van Koppen, Björn, Kaiser
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Function of muscarinic and nicotinic acetylcholine receptors

Nature, 1976
ACETYLCHOLINE receptors in vertebrates can be classified in two categories—nicotinic and muscarinic—on the basis of differential sensitivity to agonist and antagonist compounds1,2. This pharmacological distinction, although useful both in therapeutics and in experimental physiology, has no known biological significance.
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Allosteric antagonists of the muscarinic acetylcholine receptor

Biochemical Pharmacology, 1991
For the most part, the interaction of these selective antagonists with muscarinic receptors has been interpreted in the context of simple competitive bimolecular reaction which obeys the law of mass action. In fact, the use of selective antagonists as a pharmacological tool to identify receptor types and subtypes is based on this premise.
N H, Lee, E E, el-Fakahany
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Immunochemical Studies of the Muscarinic Acetylcholine Receptor

Journal of Receptor Research, 1987
Muscarinic receptors have been purified from calf forebrain plasma cell membranes by affinity chromatography on a dexetimide-agarose gel. SDS-PAGE analysis showed a single 70 kDa band. Monoclonal antibodies have been prepared against these affinity purified 70 kDa protein(s).
C, André, S, Marullo, J G, Guillet, A, Convents, M, Lauwereys, S, Kaveri, J, Hoebeke, A D, Strosberg   +7 more
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Muscarinic Acetylcholine Receptors in the Urinary Tract

2011
Muscarinic receptors comprise five cloned subtypes, encoded by five distinct genes, which correspond to pharmacologically defined receptors (M(1)-M(5)). They belong to the family of G-protein-coupled receptors and couple differentially to the G-proteins.
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Biochemical Studies on the Muscarinic Acetylcholine Receptor

1988
The muscarinic acetylcholine receptor was functionally defined, based on the actions of specific drugs on specific cells or tissues (for a review, see ref. 1). The development of specific radio-labeled ligands (2,3) enabled us to estimate and characterize the ligand-binding sites independently of their functions. Quantitative analysis of the binding of
T, Haga, G, Berstein, T, Nishiyama, H, Uchiyama, K, Ohara, K, Haga   +5 more
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Muscarinic acetylcholine receptors in the lung

Biochemical Society Transactions, 1991
D C, Murray, M, Mosley, P G, Strange
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