Results 171 to 180 of about 53,107 (259)

A Rab10-ACAP1-Arf6 GTPases cascade modulates M4 muscarinic acetylcholine receptor trafficking and signaling. [PDF]

Cell Mol Life Sci, 2023
Xu R, Wan M, Shi X, Ma S, Zhang L, Yi P, Zhang R.   +6 more
europepmc   +1 more source

CreoPep: A Universal Deep Learning Framework for Target-Specific Peptide Design and Optimization [PDF]

arXiv
Target-specific peptides, such as conotoxins, exhibit exceptional binding affinity and selectivity toward ion channels and receptors. However, their therapeutic potential remains underutilized due to the limited diversity of natural variants and the labor-intensive nature of traditional optimization strategies. Here, we present CreoPep, a deep learning-
arxiv  

Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. [PDF]

Nat Commun, 2023
Xu J, Wang Q, Hübner H, Hu Y, Niu X, Wang H, Maeda S, Inoue A, Tao Y, Gmeiner P, Du Y, Jin C, Kobilka BK.   +12 more
europepmc   +1 more source

Characterization and functional expression in mammalian cells of genomic and cDNA clones encoding a Drosophila muscarinic acetylcholine receptor.

, 1989
Robert A. Shapiro, Barbara T. Wakimoto, E M Subers, Neil M. Nathanson   +3 more
openalex   +1 more source

Charged amino acids required for signal transduction by the m3 muscarinic acetylcholine receptor. [PDF]

, 1993
Maya T. Kunkel, E G Peralta
openalex   +1 more source

Muscarinic Receptor Subtypes Mediating Positive and Negative Inotropy in the Developing Chick Ventricle

Journal of Pharmacological Sciences, 2007
The inotropic response to muscarinic receptor stimulation of isolated chick ventricular myocardium was examined at various developmental stages, and the receptor subtype involved was pharmacologically characterized.
Hideaki Nouchi, Seri Kaeriyama, Akiko Muramatsu, Masumi Sato, Kunihiko Hirose, Nagako Shimizu, Hikaru Tanaka, Koki Shigenobu   +7 more
doaj  

The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands. [PDF]

Nat Commun, 2022
Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T.   +15 more
europepmc   +1 more source

Recognition of the muscarinic receptor by its endogenous neurotransmitter: binding of [3H]acetylcholine and its modulation by transition metal ions and guanine nucleotides.

, 1984
David Gurwitz, Yoel Kloog, M Sokolovsky
openalex   +1 more source

Effects of magnesium ion on the interaction of atrial muscarinic acetylcholine receptors and GTP-binding regulatory proteins [PDF]

, 1992
Kazumasa Shiozaki, Tatsuya Haga
openalex   +1 more source

Regulation of acetylcholine release from guinea-pig bladder urothelial cells - potential role in bladder filling sensations [PDF]

, 2014
Fry, C. H., McLatchie, L. M., Young, John S.   +2 more
core   +1 more source