Results 231 to 240 of about 29,139 (279)
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Muscarinic acetylcholine receptors and airway diseases
Pharmacology & Therapeutics, 2003Parasympathetic nerves provide the dominant autonomic innervation of the airways. Release of acetylcholine from parasympathetic nerves activates postjunctional muscarinic receptors present on airway smooth muscle, submucosal glands, and blood vessels to cause bronchoconstriction, mucus secretion, and vasodilatation, respectively.
Coulson, Fiona R., Fryer, Allison D.
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The conformational switch in muscarinic acetylcholine receptors
Life Sciences, 2001The recently-determined structure of rhodopsin has provided a suitable basis for modeling the three-dimensional structure of the M1 muscarinic acetylcholine receptor. Using this as a framework for interpreting mutagenesis studies, we have been able to suggest most of the contacts which the receptor makes with acetylcholine and many of the ...
Z-L. Lu +4 more
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Muscarinic Acetylcholine Receptors
1988The central and peripheral actions of the endogenous neurotransmitter acetylcholine (ACh) are exerted at two main types of receptor, present in both the central and peripheral nervous system of all mammals. Their definition and pharmacological classification dates back to the work of Sir Henry Dale (1914), who demonstrated that certain actions of ACh ...
J. Järv, Tamas Bartfai
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Muscarinic acetylcholine receptors in cat iris
Biochemical Pharmacology, 1979Abstract The binding of tritium labeled N- methyl -4- piperidylbenzilate ([ 3 H ]-4- NMPB ) to fractions obtained from cat irides was investigated. The binding of this highly potent muscarinic antagonist to the cat iris consisted of two components: (a) high affinity binding sites with low capacity and (b) low affinity binding sites ...
Amos D. Korczyn +4 more
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Allosteric modulation of muscarinic acetylcholine receptors
Trends in Pharmacological Sciences, 1995Five subtypes of muscarinic acetylcholine receptors have been identified in mammalian tissues, but the selectivity of ligands that are active at these receptors is low. It is possible, however, that selective compounds may be developed by targeting their allosteric site(s).
Jan Proška, Stanislav Tuček
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Muscarinic Acetylcholine Receptors
1992In 1914 Dale discovered two types of response to acetylcholine, one mimicked by muscarine and one by nicotine (Dale 1914; Dale and Ewin, 1914). This led to the subsequent discovery of nicotinic and muscarinic acetylcholine receptors. In addition to their pharmacological differences, muscarinic and nicotinic receptors can be differentiated by the ...
Allan I. Levey +8 more
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Regulation of muscarinic acetylcholine receptor signaling
Pharmacology & Therapeutics, 2003Multiple mechanisms regulate the signaling of the five members of the family of the guanine nucleotide binding protein (G protein)-coupled muscarinic acetylcholine (ACh) receptors (mAChRs). Following activation by classical or allosteric agonists, mAChRs can be phosphorylated by a variety of receptor kinases and second messenger-regulated kinases.
Björn Kaiser, Chris J. van Koppen
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Biochemical Studies on the Muscarinic Acetylcholine Receptor [PDF]
, 1988 The muscarinic acetylcholine receptor was functionally defined, based on the actions of specific drugs on specific cells or tissues (for a review, see ref. 1). The development of specific radio-labeled ligands (2,3) enabled us to estimate and characterize the ligand-binding sites independently of their functions. Quantitative analysis of the binding of
Haruaki Uchiyama +5 more
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Muscarinic acetylcholine receptors of rat lymphocytes
Biochimica et Biophysica Acta (BBA) - General Subjects, 1983The muscarinic acetylcholine receptors on rat lymphocytes were determined by [3H]quinuclidinyl benzilate binding studies. Binding of [3H]quinuclidinyl benzilate is rapid (half saturation occurred within 120 s) and highly specific. Muscarinic receptors reveal high lability. The number of receptors on plasma membrane depends on time of incubation as well
Włodzimierz Maśliński +3 more
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Regulation and trafficking of muscarinic acetylcholine receptors
Neuropharmacology, 2018Fidelity of signal transduction relies on cells expressing the appropriate number of functional receptors. Fluctuation in the total number of muscarinic acetylcholine receptors has been implicated in a range of physiological and pathophysiological processes, and the mechanisms responsible for this regulation represent potential molecular targets for ...
Dmitry Zenko, James N. Hislop
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