Results 51 to 60 of about 7,723 (245)

Error Traps in Pediatric Neuromuscular Block

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Neuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological ...
Gabriel Soares de Sousa, Debra Faulk, Vinicius Caldeira Quintao, Niekoo Abbasian, Hans D. de Boer, Ricardo Vieira Carlos   +5 more
wiley   +1 more source

Modulation of cholinergic synaptic transmission in an identified locust sensory pathway [PDF]

, 2000
The monosynaptic connection between the locust forewing stretch receptor (fSR) and the first basalar motoneuron (BAl) is part of a sensory pathway involved in flight.
Judge, Sarah Jane
core  

Molecular Biological Mechanisms of Yuan Zhi Powder in the Treatment of Alzheimer’s Disease: an Analysis Based on Network Pharmacology

Digital Chinese Medicine, 2018
: Objective To predict the main active ingredients, potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan Zhi powder was constructed by ...
Wei-Jie Qiang, Ying Chen, Fu-Yuan He, Mei-Feng Xiao, Wei-Yan Cai, Yi-Fei Dai, Qing Yang, Yu-Jie Li, Xiao-Gang Weng, Qi Li, Ya-Jie Wang, Xiao-Xin Zhu   +11 more
doaj   +1 more source

Whole‐Genome Sequencing and Resequencing of Hucho bleekeri Provides Insights into Genetic Mechanisms of Environmental Adaptation

Integrative Zoology, EarlyView.
A high‐quality chromosome‐level reference genome was constructed for Hucho bleekeri. Population structure and environmental adaptation of Hucho species were revealed by whole‐genome resequencing. ABSTRACT Salmonidae represents an important family in the study of genome evolution following genome duplication.
Yeyu Chen, Huanchao Yang, Zhao Liu, Xiaoyun Wu, Qinyao Wei, Yanling Chen, Jue Lin, Yi Yu, Quanyu Tu, Hua Li   +9 more
wiley   +1 more source

Role of Muscarinic Acetylcholine Signaling in Gastrointestinal Cancers

Biomedicines, 2019
In the tumor microenvironment, various stromal and immune cells accumulate and interact with cancer cells to contribute to tumor progression. Among stromal players, nerves have recently been recognized as key regulators of tumor growth.
Mitsuru Konishi, Yoku Hayakawa, Kazuhiko Koike   +2 more
doaj   +1 more source

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, EarlyView.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, EarlyView.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Muscarinic acetylcholine receptor m3 mutation causes urinary bladder disease and a prune-belly-like syndrome [PDF]

, 2011
Urinary bladder malformations associated with bladder outlet obstruction are a frequent cause of progressive renal failure in children. We here describe a muscarinic acetylcholine receptor M3 (CHRM3) (1q41-q44) homozygous frameshift mutation in familial ...
Woolf, A.S., Sozeri, Betül, Mohammad Reza Toliat, Thiele, H., Schaefer, F., Konrad, Martin, Woolf, Adrian S.; id_orcid, William G. Newman, Altmüller, Janine, Duncan T. Wilcox, Stefanie Weber, Neil A. Hanley, Schlingmann, Karl Peter, Betül Sozeri, Jennings, Rachel, Thiel, U., Thiele, Holger, Stuart, Helen M., Janine Altmüller, Reutter, H., Nürnberg, P., Peter Frommolt, Uwe Thiel, Frommolt, P., Frommolt, Peter, Franz Schaefer, Mir, S., Reutter, Heiko, Adrian S. Woolf, Karl Peter Schlingmann, Michael Ludwig, Martin Konrad, Ludwig, Michael, Woolf, Adrian S., Schlingmann, K.P., Newman, William G., Sozeri, B., Hoyer, Peter F., Toliat, M.R., Stuart, H.M, Jennings, R., Hanley, Neil A., Hoyer, P.F., Schaefer, Franz, Rolf Beetz, Markus Draaken, Ranjzad, P., Helen M. Stuart, Weber, Stefanie, Toliat, Mohammad Reza, Draaken, M., Hanley, Neil A.; id_orcid, Beetz, Rolf, Parisa Ranjzad, Rachel Jennings, Hanley, N.A., Heiko Reutter, Draaken, Markus, Mir, Sevgi, Nürnberg, Peter, Peter Nürnberg, Thiel, Uwe, Holger Thiele, Newman, W.G., Wilcox, D.T., Peter F. Hoyer, Ludwig, M., Altmüller, J., Konrad, M., Wilcox, Duncan T., Beetz, R., Ranjzad, Parisa, Newman, William G.; id_orcid, Sevgi Mir, Weber, S.   +74 more
core   +1 more source

Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type

Tumor Biology, 2018
Gastric cancer is the third leading cause of cancer-related death worldwide, but the mechanisms of gastric carcinogenesis are not completely understood.
Phu Hung Nguyen, Yann Touchefeu, Tony Durand, Philippe Aubert, Emilie Duchalais, Stanislas Bruley des Varannes, Christine Varon, Michel Neunlist, Tamara Matysiak-Budnik   +8 more
doaj   +1 more source

Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle

Respiratory Research, 2010
Background Acetylcholine, the primary parasympathetic neurotransmitter in the airways, plays an important role in bronchoconstriction and mucus production.
Zuyderduyn Suzanne, Hiemstra Pieter S, Rieks Daniëlle, Nanninga Janke E, Kolahian Saeed, Oenema Tjitske A, Halayko Andrew J, Meurs Herman, Gosens Reinoud   +8 more
doaj   +1 more source