Results 61 to 70 of about 7,723 (245)

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
The fatal mushroom toxin l‐(+)‐muscarine is one of the most prominent natural products. We elucidated its biosynthetic origin in the sweating mushroom Collybia rivulosa based on incorporation of stable isotope‐labeled compounds and extensive mass spectrometric analyses.
Sebastian Dörner, Kai Rogge, Felix Trottmann, Christian Hertweck, Dirk Hoffmeister   +4 more
wiley   +2 more sources

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Overview of Non-neuronal Cholinergic Systems and Their Biological

Journal of Pharmacological Sciences, 2008
Acetylcholine (ACh) is a phylogenetically ancient molecule involved in cell-to-cell signaling in almost all life-forms on earth. Cholinergic components, including ACh, choline acetyltransferase, acetylcholinesterase, and muscarinic and nicotinic ACh ...
Significance Koichiro Kawashima, Takeshi Fujii   +1 more
doaj   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Muscarinic acetylcholine receptor immunoreactivity in the amygdala: 1. Cellular distribution correlated with fear-induced behavior

, 1996
This study examined the distribution of muscarinic acetylcholine receptor-immunoreactive neurons in the amygdaloid complex of the rat, with emphasis on the central nucleus.
VanderZee, EA, Luiten, P G M, van der Zee, E A, Bohus, B, J.M Koolhaas, E.A Van der Zee, P.G.M Luiten, Luiten, PGM, B Roozendaal, Roozendaal, B, Koolhaas, JM, Koolhaas, J M, B Bohus   +12 more
core   +1 more source

Acetylcholine-induced inhibition of presynaptic calcium signals and transmitter release in the frog neuromuscular junction

Frontiers in Physiology, 2016
Acetylcholine (ACh), released from axonal terminals of motor neurones in neuromuscular junctions regulates the efficacy of neurotransmission through activation of presynaptic nicotinic and muscarinic autoreceptors.
Eduard Khaziev, Eduard Khaziev, Eduard Khaziev, Dmitry Samigullin, Dmitry Samigullin, Dmitry Samigullin, Nikita Zhilyakov, Nikita Zhilyakov, Nijaz Fatikhov, Ellya Bukharaeva, Ellya Bukharaeva, Alexej Verkhratsky, Evgeny Nikolsky, Evgeny Nikolsky, Evgeny Nikolsky   +14 more
doaj   +1 more source

Arctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance

Journal of Fish Biology, EarlyView.
Abstract Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to ...
Emily P. Williams, Les N. Harris, Jean‐Sébastien Moore, Ella K. Middleton, Shira A. Berkelhammer, Ben Speers‐Roesch, Matthew J. H. Gilbert   +6 more
wiley   +1 more source

Trafficking of M2 Muscarinic Acetylcholine Receptors [PDF]

Journal of Biological Chemistry, 1999
Internalization is an important mechanism regulating the agonist-dependent responses of G-protein-coupled receptors. The internalization of the M(2) muscarinic cholinergic receptors (mAChR) in HEK293 cells has been demonstrated to occur by an unknown mechanism that is independent of arrestins and dynamin.
A G, Roseberry, M M, Hosey
openaire   +2 more sources

Discovery of Novel and Long Acting Muscarinic Acetylcholine Receptor Antagonists

, 2016
High throughput screening and subsequent optimization led to the discovery of novel quaternary ammonium salts as highly potent muscarinic acetylcholine receptor antagonists with excellent selectivity.
Kristen E. Belmonte (2415082), Yonghui Wang (287491), Roderick S. Davis (2422657), James J. Foley (2378872), Chris J. Dehaas (2422654), Michael Salmon (2353963), Dwight M. Morrow (2415079), Dongchuan Shi (2259844), Ralph A. Rivero (1993048), Parvathi Rao (2259841), Lorena A. Kallal (440592), Jian Jin (351142), Miriam Burman (2353924), Qi Jin (12159), Michael L. Moore (1993054), Michael Palovich (2232403), Feng Wang (44414), Edward F. Webb (2353930), Henry M. Sarau (2353933), Jakob Busch-Petersen (2353945), Wei Fu (176366), Manuela Berlanga (650252)   +21 more
core   +2 more sources

The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets

Molecular Cancer
Acetylcholine (ACh) is an essential neurotransmitter that has recently gained attention for its multifunctional role in tumor immune regulation.
Chunyu Zhang, Xiangdong Guo, Yanan Wang, Shuo Zhang, Zhihua Wang   +4 more
doaj   +1 more source