Results 81 to 90 of about 7,723 (245)

Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors

, 2019
By studying red blood cell precursors and their self-renewal mechanisms, Trivedi et al. identified a potential approach to helping relieve multiple types of anemia.
Bitner, Lillian, Bitner, Lillian, Wess, Jürgen, Trivedi, Gaurang, Inoue, Daichi, Chen, Cynthia, Gönen, Mithat, Zhang, Lingbo, Abdel-Wahab, Omar, Chung, Young Rock, Abdel-Wahab, Omar, Inoue, Daichi, Taylor, Justin, Chung, Young Rock, Gönen, Mithat, Wess, Jürgen, Chen, Cynthia, Taylor, Justin, Zhang, Lingbo, Trivedi, Gaurang   +19 more
core   +1 more source

The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Pathophysiology and Pharmacotherapy of Overactive Bladder

Journal of Pharmacological Sciences, 2010
Overactive bladder (OAB) syndrome, which is characterized by a complex of storage symptoms (urinary urgency, frequency, nocturia, and urgency incontinence) is highly prevalent within the general population, causing major distress to patients in terms of ...
Masaki Yoshida, Koichi Masunaga, Takashi Nagata, Makoto Yono, Yukio Homma   +4 more
doaj   +1 more source

Chemogenetic Stimulation of the Dorsal Motor Nucleus of the Vagus Mitigates Autonomic Dysfunction and Memory Decline in Rat Model of Alzheimer‐Like Disease

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Aim To test the hypothesis that Alzheimer‐like metabolic neurodegeneration rat model leads to an autonomic dysfunction, memory impairment, and hippocampal amyloid pathology and that long‐term chemogenetic stimulation of the dorsal motor nucleus of the vagus reverses these alterations. Methods Male and female transgenic Long Evans rats received
Beatriz Pacheco Sousa, Karoline Martins dos Santos, Vagner Roberto Antunes   +2 more
wiley   +1 more source

Muscarinic Acetylcholine Receptor Immunoreactivity in the Amygdala—I. Cellular Distribution Correlated with Fear-Induced Behavior [PDF]

, 1997
This study examined the distribution of muscarinic acetylcholine receptor-immunoreactive neurons in the amygdaloid complex of the rat, with emphasis on the central nucleus.
Zee, E.A. van der, Zee, E.A. van der,, Bohus, B.,, Bohus, B., Luiten, P.G.M., Roozendaal, B.,, Roozendaal, B., Luiten, P.G.M.,, Koolhaas, J.M.,, Koolhaas, J.M.   +9 more
core  

Muscarinic Acetylcholine Receptor Immunoreactivity in the Amygdala—II. Fear-Induced Plasticity

, 1997
Changes in the distribution of muscarinic acetylcholine receptor-immunoreactive neurons were examined in the amygdaloid complex at different time-intervals following a single training session of active shock avoidance in a two-way shuttle-box. Muscarinic
VanderZee, EA, Roozendaal, B., van der Zee, E.A., Luiten, P.G.M.,, Bohus, B, Koolhaas, J.M., Hensbroek, R.A., Bohus, B.G.J., Luiten, PGM, Zee, E.A. van der,, Roozendaal, B, Koolhaas, JM, Bohus, B.,, Maat, H., Luiten, P.G.M., Hensbroek, RA, Roozendaal, B.,, Hensbroek, R.A.,, Maat, H.,, Koolhaas, J.M.,   +19 more
core   +1 more source

Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
A new galvanic skin response‐based approach offers a simple method for measuring sweating in the paws of mice. This method is used to demonstrate that cannabinoid CB1 receptors reduce baseline sweating in mice, likely via inhibition of sympathetic acetylcholine release via axonal CB1 receptors.
Natalia Murataeva, Joseph Youkilis, Yogith Rao, Alex Straiker   +3 more
wiley   +1 more source

Upregulation of alpha 7 nicotinic receptors by acetylcholinesterase c-terminal peptides

, 2009
Background: The alpha-7 nicotinic acetylcholine receptor (alpha 7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Bond, Cherie E., Cherie E Bond, Greenfield Susan A., Susan A Greenfield, Greenfield, SA, Martina Zimmermann, Zimmermann, M, Bond Cherie E., Greenfield, Susan A, Bond, CE, Zimmermann Martina, Greenfield, Susan A., Bond, Cherie E, Zimmermann, Martina, Greenfield, Susan   +14 more
core   +1 more source

Epigenetic regulation of cocaine intake through dopaminergic control of cholinergic interneurons in male mice

Nature Communications
Substance use disorders are chronic neuropsychiatric conditions influenced by multiple factors, shaping individuals’ vulnerability to addictive drugs like cocaine.
Robert G. Lewis, Lauren Otsuka, Daniela Punzo, Yasmine Sherafat, Ermanno Florio, Mingqi Zhou, Valeria Lallai, Thu Dinh Nha Pham, Marcus Seldin, Christie D. Fowler, Emiliana Borrelli   +10 more
doaj   +1 more source

Direct modulation of TRPC ion channels by Gα proteins

Frontiers in Physiology
GPCR-Gi protein pathways are involved in the regulation of vagus muscarinic pathway under physiological conditions and are closely associated with the regulation of internal visceral organs.
Hana Kang, Jinhyeong Kim, Christine Haewon Park, Byeongseok Jeong, Insuk So   +4 more
doaj   +1 more source

Microbial Metabolite‐Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Bitter taste receptors (T2Rs) play an important role in physiological and cellular responses. Bitter tasting chemicals and microbial metabolites can bind to T2R14, which enables interactions between T2R14 and specific intracellular domains of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel.
Tejas Gupte, Nisha Singh, Vikram Bhatia, Kavisha Arora, Shayan Amiri, Paul Fernyhough, Anjaparavanda P. Naren, Shyamala Dakshinamurti, Prashen Chelikani   +8 more
wiley   +1 more source