Results 111 to 120 of about 24,506 (124)

Eosinophils prevent diet-induced airway hyperresponsiveness in mice on a high-fat diet.

Am J Physiol Lung Cell Mol Physiol
Proskocil BJ, Bash GN, Jacoby DB, Fryer AD, Nie Z.   +4 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Palmitoylation of muscarinic acetylcholine receptor m2 subtypes: reduction in their ability to activate G proteins by mutation of a putative palmitoylation site, cysteine 457, in the carboxyl-terminal tail.

Archives of Biochemistry and Biophysics, 1997
A putative palmitoylation site, Cys457, of muscarinic acetylcholine receptor m2 subtype (m2 receptor) was eliminated by conversion to alanine or stop codon by site-directed mutagenesis. The mutant m2 receptor C457A was not metabolically labeled with [3H]
M. Hayashi, T. Haga
semanticscholar   +1 more source

Desensitization of human muscarinic acetylcholine receptor m2 subtypes is caused by their sequestration/internalization.

Journal of Biochemistry (Tokyo), 1998
Desensitization of human muscarinic acetylcholine receptor m2 subtypes (hm2 receptors) stably expressed in chinese hamster ovary cells was measured as decreases in the carbamylcholine-stimulated [35S]GTPgammaS binding activity in membrane preparations ...
H. Tsuga, K. Kameyama, T. Haga
semanticscholar   +1 more source

Ligand-Triggered Structural Changes in the M2 Muscarinic Acetylcholine Receptor

Journal of Chemical Information and Modeling, 2018
The muscarinic M2 acetylcholine receptor, one of the few G-protein coupled receptors that has not only been crystallized in both active and inactive conformations but also in the presence of a positive allosteric modulator, is an interesting system to ...
Mireia Jiménez-Rosés, Minos-Timotheos Matsoukas, G. Caltabiano, A. Cordomí   +3 more
semanticscholar   +1 more source

Down‐regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease‐relevant genes and proteins

Journal of Neurochemistry, 2005
Beta‐amyloid peptides play a major role in the pathogenesis of Alzheimer's disease (AD). Therefore, preventing beta‐amyloid formation by inhibition of the beta site amyloid precursor protein‐cleaving enzyme (BACE) 1 is considered as a potential strategy ...
T. Zuchner, R. Schliebs, J. Perez-Polo
semanticscholar   +1 more source

Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS (Hg-derivative)

, 2018
Human muscarinic receptor M2 is one of the five subtypes of muscarinic receptors belonging to the family of G-protein-coupled receptors. Muscarinic receptors are targets for multiple neurodegenerative diseases.
Ryoji Suno, Sangbae Lee, S. Maeda, S. Yasuda, K. Yamashita, K. Hirata, S. Horita, Tawaramoto, Hirokazu Tsujimoto, T. Murata, M. Kinoshita, Masayuki Yamamoto, B. Kobilka, N. Vaidehi, S. Iwata, T. Kobayashi   +15 more
semanticscholar   +1 more source

M1 muscarinic acetylcholine receptor‐mediated inhibition of GABA release from striatal medium spiny neurons onto cholinergic interneurons

European Journal of Neuroscience, 2020
Acetylcholine (ACh) modulates neurotransmitter release in the central nervous system. Although GABAergic transmission onto the striatal cholinergic interneurons (ChIN) is modulated by dopamine receptors, cholinergic modulation of the same synapse is ...
Etsuko Suzuki, T. Momiyama
semanticscholar   +1 more source

Distribution of Like-muscarinic Acetylcholine Receptor M2 in the Brain of Three Castes of Polyrhachis vicina

, 2008
The cholinergic system plays an important role in the central nervous system of insects and is closely related to the complex behavior of insects. The immunohistochemical technique was performed to detect the expression of like-muscarinic acetylcholine ...
CuiPing Bu, GengSi Xi, Ai-ping Liang, Xia-hui Ouyang   +3 more
semanticscholar   +1 more source

The M2 muscarinic receptor, in association to M1, regulates the neuromuscular PKA molecular dynamics

The FASEB Journal, 2020
Muscarinic acetylcholine receptor 1 subtype (M1) and muscarinic acetylcholine receptor 2 subtype (M2) presynaptic muscarinic receptor subtypes increase and decrease, respectively, neurotransmitter release at neuromuscular junctions.
V. Cilleros-Mañé, L. Just-Borràs, M. Tomàs, N. Garcia, J. Tomàs, M. Lanuza   +5 more
semanticscholar   +1 more source

Autoimmunity against M2 muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy‐like phenotype

European Journal of Immunology, 2012
Patients with dilated cardiomyopathy (DCM) often have autoantibodies against cardiac antigens including the M2 muscarinic acetylcholine receptor (M2R).
A. Yoshizawa, S. Nagai, Yukiko Baba, Taketo Yamada, M. Matsui, Hikaru Tanaka, Shun‐ichiro Miyoshi, M. Amagai, T. Yoshikawa, K. Fukuda, S. Ogawa, S. Koyasu   +11 more
semanticscholar   +1 more source