Results 121 to 130 of about 34,397 (264)

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus [PDF]

, 2015
Muscarinic M1 acetylcholine receptors (M1Rs) are highly expressed in the hippocampus, and their inhibition or ablation disrupts the encoding of spatial memory.
Broad, Lisa M, Colvin, Ellen M, Dennis, Siobhan, Felder, Christian C, Fitzjohn, Steve, Isaac, John T R, Mellor, Jack, Mogg, Adrian J, Pasqui, Francesca, Sanger, Helen   +9 more
core   +2 more sources

Relationship Between Gut Microbiota and Cancer Neuro‐Immunity

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
Tumour cells influence neural activity and microbiota homeostasis through cytokines and immune modulation. Meanwhile, gut microbiota regulates neural function through metabolic products, affects immune responses via neurotransmitters, feedback regulates neural activity and influences tumour microenvironment.
Danyang Wang, Ruirui Cui, Chang You, Wanlin Zheng, Luyao Wang, Yingqi Yang, Hongkai Yu, Bota Cui   +7 more
wiley   +1 more source

Alternative Pathways of Acetylcholine Release in the Colon: Role of High‐Affinity Choline Transporters

Neurogastroenterology &Motility, Volume 38, Issue 3, March 2026.
Mechanisms of Acetylcholine release, including typical and atypical release under neuronal blockade. Left panel illustrates the classical (quantal) cholinergic transmission and the right panel the mechanism described in the present study. High‐Affinity Choline Transporter (HCT), Acetylcholine (ACh), Acetylcholinesterase (ACE), and Tetrodotoxin (TTX ...
A. Martinez‐Daunis, B. Yordanova, S. Traserra, P. Vergara, M. Jimenez   +4 more
wiley   +1 more source

Swimming against the tide: investigations of the C-Bouton synapse

Frontiers in Neural Circuits, 2014
C-boutons are important cholinergic modulatory loci for state-dependent alterations in motoneuron firing rate. Type 2 muscarinic acetylcholine (m2) receptors are concentrated postsynaptic to C-boutons, and m2 receptor activation increases motoneuron ...
Adam S. Deardorff, Shannon H. Romer, Patrick M. Sonner, Robert E.W. Fyffe   +3 more
doaj   +1 more source

Acetylcholine Release Inhibits Distinct Excitatory Inputs Onto Hippocampal CA1 Pyramidal Neurons via Different Cellular and Network Mechanisms

Frontiers in Cellular Neuroscience, 2019
In hippocampal CA1, muscarinic acetylcholine (ACh) receptor (mAChR) activation via exogenous application of cholinergic agonists has been shown to presynaptically inhibit Schaffer collateral (SC) glutamatergic inputs in stratum radiatum (SR), and ...
Priyodarshan Goswamee, A. Rory McQuiston
doaj   +1 more source

A Role for the Kolliker-Fuse Nucleus in Cholinergic Modulation of Breathing at Night During Wakefulness and NREM Sleep [PDF]

, 2010
For many years, acetylcholine has been known to contribute to the control of breathing and sleep. To probe further the contributions of cholinergic rostral pontine systems in control of breathing, we designed this study to test the hypothesis that ...
Bonis, Joshua M., Forster, Hubert V., Kiner, T., Krause, Katie L., Marshall, B. D., Neumueller, Suzanne E., Pan, Lawrence, Qian, B., Smith, A.   +8 more
core   +1 more source

Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium [PDF]

, 2018
The epithelial inner layer of the lower urinary tract, i.e., the urothelium, and other parts of the mucosa are not just a passive barrier but play an active role in the sensing of stretching, neurotransmitters, paracrine mediators, hormones, and growth ...
Chess-Williams, Russ, Michel, Martin C., Sellers, Donna   +2 more
core   +1 more source

Expression and function of G-protein-coupled receptorsin the male reproductive tract [PDF]

, 2009
This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract.
ABOUD R, ALONSO-LLAMAZARES A, ANAND-IVELL RJ, ANDERSON MB, BAN Y, BATHGATE RA, BATHGATE RA, BERNARD V, BERNARD V, BHATHAL PS, BIRDSALL NJ, BISHOP MJ, BLANCO M, BOGIC L, BORGES MOR, BRADDON SA, BRODDE OE, BURAZIN TC, BURT RP, BURT RP, CAMPOS M, Catarina S. Porto, CAULFIELD MP, CHALOTHORN D, CHAN HC, CHANG DJ, CHATURAPANICH G, CHEAH SH, CHEN S, CHEN S, COGÉ F ET AL, DA SILVA MC, DALY CJ, DANIELS DV, DAVENPORT CW, DEBRUYNE FM, DENG XF, DIVIANI D, DOCHERTY JR, DOCHERTY JR, DOGGRELL SA, DU JY, EGLEN RM, EGLEN RM, EHRÉN I, EISENHOFER G, ERRASTI AE, ESBENSHADE TA, ESSIG M, FENG S, FEVOLD HL, FILONZI M, FORD APDW, FORD APDW, FORRAY C, FUKASAWA R, GAO B, GAO B, GOBEIL F JR, GONZÁLEZ-ESPINOSA C, GRAHAM RM, GRIMM U, GUNNERSEN JM, GUNNERSEN JM, HAAG C, HAGUE C, HAGUE C, HALLS ML, HALLS ML, HALLS ML, HAMAMURA M, HANFT G, HANSELL DJ, HAUSER F, HAWRYLYSHYN KA, HEIN P, HIB J, HIB J, HIEBLE JP, HIEBLE JP, HIRASAWA A, HIRASAWA A, HIRASAWA A, HISAW FL, HOMMA Y, HORIE K, HROMETZ SL, HSU SY, HSU SY, HU K, HULEIHEL M, HULME EC, HWA J, HWA J, HWA J, II M, IRAM S, IVELL R, IVELL R, JACKSON VM, JEYABALAN A, JEYABALAN A, JIANG X, JOCKENHOVEL F, JUDSON DG, JURKIEWICZ NH, KAMAT AA, KARKANIAS GB, KERN A, KIM JK, KINGHORN EM, KOHSAKA T, KONDO S, KRAJNC-FRANKEN MA, KUBO T, KUDO M, LACEY JP, LANGER S, LANZAFAME AA, LAU WA, LAZ TM, LEEB-LUNDBERG LM, LEFKOWITZ RJ, LEFKOWITZ RJ, LEFKOWITZ RJ, LENHART JA, LEPOR H, LEUNG AYH, LIU C, LOCKWOOD DH, LONGHURST PA, LOPEZ-GIMENEZ JF, LUCAS TFG, LUCAS TFG, LUTHIN GR, MACDONALD A, MACKENZIE JF, MACKINNON AC, MALLARD NJ, MANNI L, MANNI L, Maria Christina W. Avellar, Maria Fatima M. Lázari, MARKUS RP, MARÓSTICA E, MARÓSTICA E, MCCUNE DF, MCCUNE SK, MENDES FR, MICHELOTTI GA, MICHELOTTI GA, MIRANDA HF, MIRANDA HF, MIRANDA HF, MOOKERJEE I, MORIYAMA N, MORROW AL, MURAMATSU I, MURRAY KT, NADELHAFT I, NAKAOKA H, NASU K, NASU K, NEWINGER J, NISHIS, NOTHACKER HP, OBARA K, PAPATSORIS AG, PATRÃO MT, PEDRETTI A, PEREZ DM, PETITTI N, PIASCIK MT, PIASCIK MT, PIASCIK MT, PONTARI MA, PORTER JE, PRENZEL N, PRICE DT, PRICE DT, PRICE RR, PUPO AS, PUPO AS, QUEIRÓZ DB, QUEIRÓZ DBC, QUESADA A, RAMARAO CS, RAMSAY D, RATNASOORIYA WD, RATNASOORIYA WD, RAYFORD W, RICKER DD, ROEHRBORN CG, ROKOSH DG, ROKOSH DG, RUDNER XL, RUFFOLO RR JR, RUGGIERI MR, SALAMANCA AE, SALLÉS J, SAMUEL CS, SAMUEL CS, SAMUEL CS, SANBE A, SANBORN BM, SAROSI P, SATO T, SAUSSY DL JR, SAWUTZ DG, SCARPARO AC, SCHWINN DA, SCHWINN DA, SCOFIELD MA, SCOTT DJ, SCOTT DJ, SHANNON HE, SHAPIRO E, SHEN H, SHERWOOD OD, SHIMA S, SHINOURA H, SILVA MA, SIU ER, SKINNER MK, SOKOL RZ, STEINETZ BG, SUDO S, SUGAWARA T, SUZUKI F, TAYEBATI SK, TENG CM, TENSEN CP, TESTA R, THEBAULT S, THEROUX TL, TOEWS ML, UBERTI MA, UBERTI MA, VAN DIJK MM, VAN KOPPEN CJ, VARMA DR, VENTURA S, VICENTIC A, VIVAS NM, VÁZQUEZ-PRADO J, WALDEN PD, WALKER WH, WANG JM, WANG X ET AL, WAUGH DJ, WESS J, WIER WG, XIAO L, XU Z, YAN HH, YANG M, YANG-FENG TL, YANG-FENG TL, YASUOKA A, YAZAWA H, YAZAWA H, YKI-JARVINEN H, YOSHINAGA T, ZHAO L, ZHONG H, ZHONG H, ZIMMERMANN S, ZUSCIK MJ   +267 more
core   +3 more sources

Binding and functional characterisation of allosteric agonists at M2 muscarinic acetylcholine receptors

The FASEB Journal, 2008
Muscarinic acetylcholine receptors (mAChRs) contain at least one allosteric site that is topographically distinct from the acetylcholine (ACh)‐binding orthosteric site. Although numerous studies have investigated the structural basis of allosteric modulation at these receptors, far less is known about allosteric ligands that ...
Karen Joan Gregory, Nathan E. Hall, Patrick M. Sexton, Arthur Christopoulos   +3 more
openaire   +1 more source

Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation

Gut Microbes, 2020
High-fat diet (HFD) leads to systemic low-grade inflammation, which has been involved in the pathogenesis of diverse metabolic and inflammatory diseases.
Lingyu Wang, Zizhen Gong, Xiuyuan Zhang, Fangxinxing Zhu, Yuchen Liu, Chaozhi Jin, Xixi Du, Congfeng Xu, Yingwei Chen, Wei Cai, Chunyan Tian, Jin Wu   +11 more
doaj   +1 more source