Results 101 to 110 of about 8,829 (221)

Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation

Gut Microbes, 2020
High-fat diet (HFD) leads to systemic low-grade inflammation, which has been involved in the pathogenesis of diverse metabolic and inflammatory diseases.
Lingyu Wang, Zizhen Gong, Xiuyuan Zhang, Fangxinxing Zhu, Yuchen Liu, Chaozhi Jin, Xixi Du, Congfeng Xu, Yingwei Chen, Wei Cai, Chunyan Tian, Jin Wu   +11 more
doaj   +1 more source

Internalization of the m2 Muscarinic Acetylcholine Receptor [PDF]

Journal of Biological Chemistry, 1997
Robin Pals-Rylaarsdam, Vsevolod V. Gurevich, Katharine B. Lee, Judith A. Ptasienski, Jeffrey L. Benovic, M. Marlene Hosey   +5 more
openaire   +1 more source

Novel long-range inhibitory nNOS-expressing hippocampal cells

eLife, 2019
The hippocampus, a brain region that is important for spatial navigation and episodic memory, benefits from a rich diversity of neuronal cell-types. Through the use of an intersectional genetic viral vector approach in mice, we report novel hippocampal ...
Zoé Christenson Wick, Madison R Tetzlaff, Esther Krook-Magnuson   +2 more
doaj   +1 more source

The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation

, 2005
Background— The molecular mechanism of increased background inward rectifier current (IK1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active acetylcholine (ACh)-activated IK,ACh contributes to enhanced basal ...
Ravens, U., Wettwer, E., Christ, T., Voigt, N., Friedrich, A., Knaut, M., Jost, Norbert, Dobrev, D.   +7 more
core  

functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

, 2014
Obidoxime, a weak acetylcholine-esterase (AChE) inhibitor, exerts muscarinic receptor antagonism with a significant muscarinic M2 receptor selective profile.
Vladimir Wsol, Killi, Uday Kumar, Tobin, Gunnar,, Soukup, Ondrej, Michael Winder, Uday K Killi, Winder, Michael,, Wsol, Vladimir, Kuca, Kamil, Ondrej Soukup, Kamil Kuca, Gunnar Tobin   +11 more
core   +1 more source

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source

Differential expression of the muscarinic m2 acetylcholine receptor by small and large motoneurons of the rat spinal cord

, 1999
The purpose of this study was to determine if motoneurons in the spinal ventral horn express the muscarinic m2 acetylcholine receptor. Motoneurons were retrogradely labelled in adult rats by intramuscular injection of Fluorogold and examined with ...
Maxwell, D.J., Kerr, R., Welton, J., Stewart, W.   +3 more
core   +1 more source

Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes

, 1997
In cardiac myocytes, as well as specialized conduction and pacemaker cells, agonist binding to muscarinic acetylcholine receptors (mAchRs) results in the activation of several signal transduction cascades including the endothelial isoform of nitric-oxide
Kelly, Ralph A., Michel, Thomas, Smith, Thomas W., Feron, Olivier   +3 more
core   +1 more source

Primary structure and biochemical properties of an M2 muscarinic receptor

, 1987
A partial amino acid sequence obtained for porcine atrial muscarinic acetylcholine receptor was used to isolate complementary DNA clones containing the complete receptor coding region.
Smith, D. H., Capon, D. J., Schimerlik, M. I., Ramachandran, J., Winslow, J. W., Peterson, G. L., Ashkenazi, A., Peralta, E. G.   +7 more
core   +1 more source

Exploring functional motions of muscarinic acetylcholine M2 receptor

, 2020
G-protein bağlı reseptörler (GPRs) en büyük sinyal protein ailesidir ve bu yüzden işleyiş mekanızmalarının altında yatan dinamik etkenlerin anlaşılması ilaç tasarımında büyük bir öneme sahiptir. Bu güne kadar yapılan pek çok çalışma olmasına rağmen, inaktif ve aktif yapılar arasında gerçekleşen kolektif konformasyonel değişimlerin özellikleri ve ...
openaire   +1 more source