Results 91 to 100 of about 8,829 (221)

Multifaceted Evaluation of Syngonium podophyllum Flower Extracts: Anthelmintic, Antidiabetic, Antipyretic, and Antidiarrheal Potentials via Experimental, In Silico, and DFT Approaches

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
The methanolic extract of Syngonium podophyllum flower demonstrated significant anthelmintic, antidiabetic, antidiarrheal, and antipyretic effects across all in vitro and in vivo experimental models. Furthermore, in silico studies revealed that these phytoconstituents exhibit favorable pharmacokinetic properties, interact with key therapeutic target ...
Mahathir Mohammad, Nusrat Jahan Moon, Md. Hossain Rasel, Md. Anisul Islam, Nazmul Hasan Eshaque, Md. Jahirul Islam Mamun, Md. Zamil Hossain, Md. Mahmudul Hasan, Md. Tanvir Chowdhury, S. M. Moazzem Hossen   +9 more
wiley   +1 more source

Muscarinic M2 receptor promotes vasopressin synthesis in mice supraoptic nuclei

, 2018
Muscarinic acetylcholine receptors have been suggested to be implicated in arginine–vasopressin secretion because intracerebroventricular muscarinic agonist administration induces arginine–vasopressin release into the circulation.
Hayato Matsuyama, Yasuyuki Tanahashi, Hiroshi Nagano, Yuki Sobue, Hiroki Sakai, Firoj Alom, Toshihiro Unno, Shoichiro Saito, Toshiaki Ishii   +8 more
core   +1 more source

Swimming against the tide: investigations of the C-Bouton synapse

Frontiers in Neural Circuits, 2014
C-boutons are important cholinergic modulatory loci for state-dependent alterations in motoneuron firing rate. Type 2 muscarinic acetylcholine (m2) receptors are concentrated postsynaptic to C-boutons, and m2 receptor activation increases motoneuron ...
Adam S. Deardorff, Shannon H. Romer, Patrick M. Sonner, Robert E.W. Fyffe   +3 more
doaj   +1 more source

Acetylcholine Release Inhibits Distinct Excitatory Inputs Onto Hippocampal CA1 Pyramidal Neurons via Different Cellular and Network Mechanisms

Frontiers in Cellular Neuroscience, 2019
In hippocampal CA1, muscarinic acetylcholine (ACh) receptor (mAChR) activation via exogenous application of cholinergic agonists has been shown to presynaptically inhibit Schaffer collateral (SC) glutamatergic inputs in stratum radiatum (SR), and ...
Priyodarshan Goswamee, A. Rory McQuiston
doaj   +1 more source

Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels

, 2005
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC, Tatulian, L, Hughes, S, Brown, DA, Marsh, SJ, Winks, JS, Filippov, AK   +6 more
core  

a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist

, 2020
Previous work from our laboratory indicates that bile acids, specifically lithocholic acid conjugates, interact with muscarinic receptors on gastric chief cells.
Kunrong Cheng, Richard H Kennedy, Piotr Zimniak, Ying Chen, Jean-Pierre Raufman, Sandeep Khurana   +5 more
core  

Modulation of M2 muscarinic receptor–receptor interaction by immunoglobulin G antibodies from Chagas' disease patients

, 2011
Summary Circulating immunoglobulin (Ig)G antibodies against M2 muscarinic acetylcholine receptors (M2 mAChR) have been implicated in Chagas' disease (ChD) pathophysiology.
C I Waldner, J C Goin, S P Beltrame, S R Auger, C R Bilder   +4 more
core   +1 more source

Ozone-induced airway hyperresponsiveness and loss of neuronal M2 muscarinic receptor function

, 1994
The effect of acute ozone exposure on the function of efferent parasympathetic nerves, M3 muscarinic receptors on airway smooth muscle, and inhibitory M2 muscarinic receptors on the parasympathetic nerves was studied.
A. H. Schultheis, D. J. Bassett, A. D. Fryer   +2 more
core   +1 more source

Impaired object-location learning and recognition memory but enhanced sustained attention in M2 muscarinic receptor-deficient mice [PDF]

, 2018
[Carola Romberg-Taylor credited as Carola Romberg] Rationale: Muscarinic acetylcholine receptors are known to play key roles in mediating cognitive processes, and impaired muscarinic cholinergic neurotransmission is associated with normal ageing ...
Bussey, Timothy J., Romberg-Taylor, Carola, Saksida, Lisa M., Wess, Jürgen, Bartko, Susan   +4 more
core   +1 more source

Binding and functional characterisation of allosteric agonists at M2 muscarinic acetylcholine receptors

The FASEB Journal, 2008
Muscarinic acetylcholine receptors (mAChRs) contain at least one allosteric site that is topographically distinct from the acetylcholine (ACh)‐binding orthosteric site. Although numerous studies have investigated the structural basis of allosteric modulation at these receptors, far less is known about allosteric ligands that ...
Karen Joan Gregory, Nathan E. Hall, Patrick M. Sexton, Arthur Christopoulos   +3 more
openaire   +1 more source