Results 71 to 80 of about 8,829 (221)

Involvement of HCN Channel in Muscarinic Inhibitory Action on Tonic Firing of Dorsolateral Striatal Cholinergic Interneurons

open access: yesFrontiers in Cellular Neuroscience, 2016
The striatum is the most prominent nucleus in the basal ganglia and plays an important role in motor movement regulation. The cholinergic interneurons (ChIs) in striatum are involved in the motion regulation by releasing acetylcholine (ACh) and ...
Zhe eZhao   +8 more
doaj   +1 more source

Effects of Icariin and Its Metabolites on GPCR Regulation and MK-801-Induced Schizophrenia-Like Behaviors in Mice

open access: yesMolecules, 2023
Icariin, a major bioactive compound found in the Epimedium genus, has been reported to exert protective effects against neurodegenerative disorders. In the current study, we aimed to investigate the regulatory effect of icariin and its active metabolites
Su Hui Seong   +5 more
doaj   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

open access: yeseFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam   +4 more
wiley   +1 more source

Modulation of cholinergic synaptic transmission in an identified locust sensory pathway [PDF]

open access: yes, 2000
The monosynaptic connection between the locust forewing stretch receptor (fSR) and the first basalar motoneuron (BAl) is part of a sensory pathway involved in flight.
Judge, Sarah Jane
core  

Gastric Cancer: Pathobiology and Therapeutics

open access: yesMedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu   +16 more
wiley   +1 more source

The Role of Voltage-Gated Sodium Channel 1.8 in the Effect of Atropine on Heart Rate: Evidence From a Retrospective Clinical Study and Mouse Model

open access: yesFrontiers in Pharmacology, 2020
Atropine is commonly used to counter the effects of the parasympathetic neurotransmitter acetylcholine on heart rate in clinical practice, such as in the perioperative period; however, individual differences in the response to atropine are huge.
Baowen Liu   +9 more
doaj   +1 more source

Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice

open access: yesAlzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION The degeneration of basal forebrain cholinergic neurons is a key pathophysiological feature of Alzheimer's disease (AD). These cholinergic neurons target cortical neurons including those in the granular retrosplenial cortex (RSG) to facilitate essential cognitive functions.
Chloe I. Rybicki‐Kler   +7 more
wiley   +1 more source

The structure of the third intracellular loop of the muscarinic acetylcholine receptor M2 subtype [PDF]

open access: yesFEBS Letters, 2005
We have examined whether the long third intracellular loop (i3) of the muscarinic acetylcholine receptor M2 subtype has a rigid structure. Circular dichroism (CD) and nuclear magnetic resonance spectra of M2i3 expressed in and purified from Escherichia coli indicated that M2i3 consists mostly of random coil.
Ichlyama, S   +6 more
openaire   +2 more sources

Distribution of Like-muscarinic Acetylcholine Receptor M2 in the Brain of Three Castes of Polyrhachis vicina

open access: yes, 2009
The cholinergic system plays an important role in the central nervous system of insects and is closely related to the complex behavior of insects. The immunohistochemical technique was performed to detect the expression of like-muscarinic acetylcholine ...
OUYANG, Xia-hui   +3 more
core   +1 more source

Uniqueness of Supramolecular Systems

open access: yesMacromolecular Materials and Engineering, Volume 311, Issue 5, May 2026.
Thanks to the variety of classes of supramolecular systems, they have been widely used in various applications. For example, in sensing devices, catalysis, and biomedicine. An example of a conventional photovoltaic material converted into electrical energy. Selective UV or NIR absorbers are required to produce materials with low or no coloration.
José A. Sánchez‐Fernández
wiley   +1 more source

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