Results 81 to 90 of about 34,397 (264)

Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION The degeneration of basal forebrain cholinergic neurons is a key pathophysiological feature of Alzheimer's disease (AD). These cholinergic neurons target cortical neurons including those in the granular retrosplenial cortex (RSG) to facilitate essential cognitive functions.
Chloe I. Rybicki‐Kler, Isla A. W. Brooks, Izabela Jedrasiak‐Cape, Tao Deng, Cassandra Avila, Elizabeth Brouns, Alex Lekander, Omar J. Ahmed   +7 more
wiley   +1 more source

Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients

Cardiology Research and Practice, 2019
Objectives. To investigate the association of serum autoantibodies against M2-muscarinic acetylcholine receptor (anti-M2-R) with atrial fibrosis in long-standing persistent atrial fibrillation (AF) patients. Methods.
Guiling Ma, Xuejiao Wu, Lijun Zeng, Jiawei Jin, Xingpeng Liu, Jianjun Zhang, Lin Zhang   +6 more
doaj   +1 more source

Increased ACh-Associated Immunoreactivity in Autonomic Centers in PTZ Kindling Model of Epilepsy

Biomedicines, 2020
Experimental and clinical studies of cardiac pathology associated with epilepsy have demonstrated an impact on the autonomic nervous system (ANS). However, the underlying molecular mechanism has not been fully elucidated.
Enes Akyüz, Züleyha Doğanyiğit, Yam Nath Paudel, Emin Kaymak, Seher Yilmaz, Arda Uner, Mohd. Farooq Shaikh   +6 more
doaj   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

Interactions between the neuromodulatory systems and the amygdala: exploratory survey using the Allen Mouse Brain Atlas. [PDF]

, 2013
Neuromodulatory systems originate in nuclei localized in the subcortical region of the brain and control fundamental behaviors by interacting with many areas of the central nervous system.
Krichmar, Jeffrey L, Zaldivar, Andrew
core   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, Volume 81, Issue 5, Page 1617-1634, May 2026.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Immunization with plasmids encoding M2 acetylcholine muscarinic receptor epitopes impairs cardiac function in mice and induces autophagy in the myocardium

Autoimmunity, 2018
Autoantibodies against the M2 subtype of muscarinic acetylcholine receptors with functional activities have been found in the sera of patients with dilated cardiomyopathy (DCM), and the second extracellular loop has been established as the predominant ...
Karla Consort Ribeiro, Roberto Perez Campelo, Daniela del Rosário Flores Rodrigues, Elisabete C. Mattos, Izaira Trincani Brandão, Célio Lopes da Silva, Eliete Bouskela, Camila Guerra Martinez, Eleonora Kurtenbach   +8 more
doaj   +1 more source

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]

, 2017
Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core   +1 more source

Synergistic Regulation of m2 Muscarinic Acetylcholine Receptor Desensitization and Sequestration by G Protein-coupled Receptor Kinase-2 and β-Arrestin-1*

Journal of Biological Chemistry, 1997
The m2 muscarinic acetylcholine receptor (m2 mAChR) belongs to the superfamily of G protein-coupled receptors and is regulated by many processes that attenuate signaling following prolonged stimulation by agonist. We used a heterologous expression system
M. L. Schlador, N. Nathanson
semanticscholar   +1 more source

Dualsteric Agonist for M2 Muscarinic Receptor Causes Oxidative Stress and Mitochondrial Alteration in Human Glioblastoma Cancer Stem Cells

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Dualsteric agonist N8‐iper shows cytotoxic effects on glioblastoma cancer stem cells, but not on human normal astrocytes. Lipid accumulation appears as a consequence of cytotoxic stress; in fact, they are not present in healthy astrocytes. ABSTRACT Glioblastoma (GB) is the most malignant form of human brain tumor, characterized by heterogeneous cell ...
Claudia Guerriero, Chiara De Nuccio, Maria Petrone, Teresa Rinaldi, Angela Cirigliano, Sergio Visentin, Antonietta Bernardo, Luciano Conti, Carlo Matera, Marco De Amici, Clelia Dallanoce, Ada Maria Tata   +11 more
wiley   +1 more source