Results 141 to 150 of about 34,397 (264)

Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome.

Human Molecular Genetics, 2004
Jen C. Wang, Anthony L. Hinrichs, Heather Stock, J. Budde, Rebecca Allen, S. Bertelsen, J. Kwon, William S. Wu, D. Dick, J. Rice, K. Jones, J. Nurnberger, J. Tischfield, B. Porjesz, H. Edenberg, V. Hesselbrock, R. Crowe, M. Schuckit, H. Begleiter, T. Reich, A. Goate, L. Bierut   +21 more
semanticscholar   +1 more source

G fehérjék szerepe a húgyhólyag simaizom-működésének szabályozásában. = G protein-mediated regulation of urinary smooth muscle contractility. [PDF]

, 2009
Eredményeink szerint élettani körülmények között a Gq/11 jelátviteli út (vélhetőleg az M3-receptorok által aktiválva) döntő szerepet játszik az acetilkolin simaizom-kontrakciót okozó hatásának közvetítésében és ezáltal a húgyhólyag működésének ...
Benyó, Zoltán
core  

Exploring functional motions of muscarinic acetylcholine M2 receptor

, 2020
G-protein bağlı reseptörler (GPRs) en büyük sinyal protein ailesidir ve bu yüzden işleyiş mekanızmalarının altında yatan dinamik etkenlerin anlaşılması ilaç tasarımında büyük bir öneme sahiptir. Bu güne kadar yapılan pek çok çalışma olmasına rağmen, inaktif ve aktif yapılar arasında gerçekleşen kolektif konformasyonel değişimlerin özellikleri ve ...
openaire   +1 more source

Gomisin E attenuates pentobarbital-induced sleep deficits in aging-related insomnia: an in vivo and in silico study implicating cholinergic signaling

Frontiers in Psychology
ObjectiveTo investigate the therapeutic effects of gomisin E on insomnia in aged rats and to elucidate the underlying mechanisms.MethodsAn aging-related insomnia rat model was established by intraperitoneal injection of D-galactose combined with p ...
Fan Yang, Fen Jiang, Fen Jiang, Xuewei Li   +3 more
doaj   +1 more source

The G alpha q and G alpha 11 proteins couple the thyrotropin-releasing hormone receptor to phospholipase C in GH3 rat pituitary cells [PDF]

, 1992
Thyrotropin-releasing hormone stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) in GH3 cell membranes. The stimulation of the phosphoinositide phospholipase C (PI/PLC) activity can be blocked by incubation of GH3 membranes with ...
Aragay, Anna M., Katz, Arieh, Simon, Melvin I.   +2 more
core  

Modular horizontal network within mouse primary visual cortex

Frontiers in Neuroanatomy
Interactions between feedback connections from higher cortical areas and local horizontal connections within primary visual cortex (V1) were shown to play a role in contextual processing in different behavioral states.
Andreas Burkhalter, Weiqing Ji, Andrew M. Meier, Andrew M. Meier, Rinaldo D. D’Souza   +4 more
doaj   +1 more source

Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder.

Human Molecular Genetics, 2009
S. Cohen-Woods, D. Gaysina, N. Craddock, A. Farmer, J. Gray, C. Gunasinghe, F. Hoda, L. Jones, J. Knight, A. Korszun, M. Owen, A. Sterne, I. Craig, P. McGuffin   +13 more
semanticscholar   +1 more source

D₂ Dopamine Receptors Colocalize Regulator of G-Protein Signaling 9-2 (RGS9-2) via the RGS9 DEP Domain, and RGS9 Knock-Out Mice Develop Dyskinesias Associated with Dopamine Pathways [PDF]

, 2005
Regulator of G-protein signaling 9-2 (RGS9-2), a member of the RGS family of Gα GTPase accelerating proteins, is expressed specifically in the striatum, which participates in antipsychotic-induced tardive dyskinesia and in levodopa-induced dyskinesia. We
Axelrod, Jeffrey D., Barghshoon, Sami, Chen, Ching-Kang, Cheyette, Benjamin N. R., Ebert, Jana, Kovoor, Abraham, Lester, Henry A., Schwarz, Johannes, Schwarz, Sigrid, Seyffarth, Petra, Simon, Melvin I.   +10 more
core  

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations [PDF]

, 1992
We measured the permeability ratios (PX/PNa) of 3 wild-type, 1 hybrid, 2 subunit-deficient, and 22 mutant nicotinic receptors expressed in Xenopus oocytes for alkali metal and organic cations using shifts in the bi-ionic reversal potential of the ...
Cohen, Bruce N., Davidson, Norman, Labarca, Cesar, Lester, Henry A.   +3 more
core  

Muscarinic acetylcholine receptor M2 (CHRM2; HM2) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source