Results 121 to 130 of about 11,132 (239)

Effects of Partial Agonists and Mg2+ Ions on the Interaction of M2 Muscarinic Acetylcholine Receptor and G Protein G i1 Subunit in the M2-G i1 Fusion Protein [PDF]

, 2004
Qiming Zhang
openalex   +1 more source

Vagus nerve stimulation as a modulator of feedforward and feedback neural transmission [PDF]

arXiv
Vagus nerve stimulation (VNS) has emerged as a promising therapeutic intervention across various neurological and psychiatric conditions, including epilepsy, depression, and stroke rehabilitation; however, its mechanisms of action on neural circuits remain incompletely understood.
arxiv  

Identification of a Novel Apical Sorting Motif and Mechanism of Targeting of the M2 Muscarinic Acetylcholine Receptor [PDF]

, 2006
Renée S. Chmelar, Neil M. Nathanson
openalex   +1 more source

The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.

PLoS Biology
Muscarinic acetylcholine receptors are prototypical G protein-coupled receptors (GPCRs), members of a large family of 7 transmembrane receptors mediating a wide variety of extracellular signals. We show here, in cultured cells and in a murine model, that
Irene Fasciani, Francesco Petragnano, Ziming Wang, Ruairidh Edwards, Narasimha Telugu, Ilaria Pietrantoni, Ulrike Zabel, Henrik Zauber, Marlies Grieben, Maria E Terzenidou, Jacopo Di Gregorio, Cristina Pellegrini, Silvano Santini, Anna R Taddei, Bärbel Pohl, Stefano Aringhieri, Marco Carli, Gabriella Aloisi, Francesco Marampon, Eve Charlesworth, Alexandra Roman, Sebastian Diecke, Vincenzo Flati, Franco Giorgi, Fernanda Amicarelli, Andrew B Tobin, Marco Scarselli, Kostas Tokatlidis, Mario Rossi, Martin J Lohse, Paolo Annibale, Roberto Maggio   +31 more
doaj   +1 more source

CreoPep: A Universal Deep Learning Framework for Target-Specific Peptide Design and Optimization [PDF]

arXiv
Target-specific peptides, such as conotoxins, exhibit exceptional binding affinity and selectivity toward ion channels and receptors. However, their therapeutic potential remains underutilized due to the limited diversity of natural variants and the labor-intensive nature of traditional optimization strategies. Here, we present CreoPep, a deep learning-
arxiv  

Inhaled glycopyrrolate for the treatment of chronic obstructive pulmonary disease

International Journal of COPD, 2018
Donald P Tashkin,1 Nicholas J Gross2 1Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Department of Medicine, University Medical Research LLC, Saint Francis Hospital and Medical Center, Hartford, CT, USA Abstract:
Tashkin DP, Gross NJ
doaj  

Role of M2 and M3 Muscarinic Acetylcholine Receptor Subtypes in Activation of Bladder Afferent Pathways in Spinal Cord Injured Rats [PDF]

, 2012
Yoshihiro Matsumoto, Minoru Miyazato, Hitoshi Yokoyama, Masafumi Kita, Yoshihiko Hirao, Michael B. Chancellor, Naoki Yoshimura   +6 more
openalex   +1 more source

Muscarinic acetylcholine receptor M2 (CHRM2; HM2) [PDF]

, 2012
Tatsuya Haga, Brian K. Kobilka
openalex   +1 more source

EFFECTS OF AUTOANTIBODY AGAINST M2-MUSCARINIC ACETYLCHOLINE RECEPTOR IN PERIPARTUM CARDIOMYOPATHY PATIENTS ON DIGOXIN ADDITIONAL TO STANDARD TREATMENT

, 2021
Guiling Ma, Shi Cheng, Yin Yue, Long Chen, Yidan Wang, Xiyan Liu, Yingshih Lo, Lin Zhang   +7 more
openalex   +1 more source

Proteoliposome-based Selection of a Recombinant Antibody Fragment Against the Human M2 Muscarinic Acetylcholine Receptor [PDF]

, 2014
Suharni, Yayoi Nomura, T. Arakawa, Tomoya Hino, Hitomi Abe, Yoshiko Nakada-Nakura, Yumi Sato, Hiroko Iwanari, Mitsunori Shiroishi, Hidetsugu Asada, Tatsuro Shimamura, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, So Iwata, Norimichi Nomura   +15 more
openalex   +1 more source