Results 21 to 30 of about 7,912 (220)

Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]

Genes, 2013
Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven transmembrane helix receptors.
Ockenga, Wymke, Kühne, Sina, Bocksberger, Simone, Banning, Antje, Tikkanen, Ritva, Justus Liebig University Giessen   +5 more
openaire   +5 more sources

Internalization of the m2 Muscarinic Acetylcholine Receptor [PDF]

Journal of Biological Chemistry, 1997
Recent studies have identified agonist-dependent phosphorylation as a critical event in the rapid uncoupling of the m2 muscarinic cholinergic receptors (mAChR) from G-proteins and sequestration of the receptors away from the cell surface. However, mutant m2 mAChRs were identified that were phosphorylated but unable to desensitize in adenylyl cyclase ...
Katharine B. Lee, Robin Pals-Rylaarsdam, M. Marlene Hosey, Vsevolod V. Gurevich, Judith A. Ptasienski, Jeffrey L. Benovic   +5 more
openaire   +3 more sources

Tracking Voltage-Sensitive Movements of the M2 Muscarinic Acetylcholine Receptor [PDF]

Biophysical Journal, 2015
Numerous G protein-coupled receptors (GPCRs) have been shown to change their activity levels in response to changes in membrane potential. More recently, it has been directly demonstrated that these changes in activity reflect underlying changes in conformational state.
Francisco Bezanilla, Ofra Barchad-Avitzur, Yair Ben-Chaim, Noa Dekel, Michael F. Priest   +4 more
openaire   +2 more sources

On homology modeling of the M2 muscarinic acetylcholine receptor subtype [PDF]

Journal of Computer-Aided Molecular Design, 2013
Twelve homology models of the human M(2) muscarinic receptor using different sets of templates have been designed using the Prime program or the modeller program and compared to crystallographic structure (PDB:3UON). The best models were obtained using single template of the closest published structure, the M(3) muscarinic receptor (PDB:4DAJ).
Jan Jakubík, Alena Randáková, Vladimír Doležal   +2 more
openaire   +2 more sources

Porcine m2 Muscarinic Acetylcholine Receptor-Effector Coupling in Chinese Hamster Ovary Cells [PDF]

Journal of Biological Chemistry, 1995
The relationship between porcine m2 muscarinic receptor coupling to inhibition of cAMP formation and stimulation of phosphatidylinositol metabolism in Chinese hamster ovary cells was examined. Reduction of the number of receptors per cell with the slowly dissociating antagonist (-)-quinuclidinyl benzilate caused a decrease in maximal response with no ...
W. Vogel, Valerie A. Mosser, Dylan A. Bulseco, Michael I. Schimerlik   +3 more
openalex   +5 more sources

Unraveling a molecular determinant for clathrin-independent internalization of the M2 muscarinic acetylcholine receptor [PDF]

Scientific Reports, 2015
AbstractEndocytosis and postendocytic sorting of G-protein-coupled receptors (GPCRs) is important for the regulation of both their cell surface density and signaling profile. Unlike the mechanisms of clathrin-dependent endocytosis (CDE), the mechanisms underlying the control of GPCR signaling by clathrin-independent endocytosis (CIE) remain largely ...
Min Wan, Wenhua Zhang, Yangli Tian, Chanjuan Xu, Tao Xu, Jianfeng Liu, Rongying Zhang   +6 more
openalex   +4 more sources

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj   +1 more source

Position of anticholinergic drugs in the treatment of childhood asthma [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2010
Anticholinergic drugs block muscarinic effect of acetylcholine on the receptors of postjunctional membranes and so inhibit the answer of the postganglionic parasympathetic nerve.
Stojković-Anđelković Anđelka, Obradović Slobodan, Vuletić Biljana, Radlović Vladimir   +3 more
doaj   +1 more source

Neuromodulation of Persistent Activity and Working Memory Circuitry in Primate Prefrontal Cortex by Muscarinic Receptors

Frontiers in Neural Circuits, 2021
Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls the gating of cortical sensory stimulus responses, and has been shown
Susheel Vijayraghavan, Stefan Everling, Stefan Everling   +2 more
doaj   +1 more source

TLR2 and TLR4 Modulate Mouse Ileal Motility by the Interaction with Muscarinic and Nicotinic Receptors

Cells, 2022
Irritable bowel syndrome (IBS) is a chronic functional bowel disorder characterized by intestinal dysmotility. Changes in intestinal microbiota (dysbiosis) can lead to alterations in neuro-muscular functions in the gut. Toll-like receptors (TLRs) 2 and 4
Elena Layunta, Raquel Forcén, Laura Grasa   +2 more
doaj   +1 more source