Results 21 to 30 of about 24,506 (124)
Journal of Medicinal Chemistry, 2020 Fluorescently labeled dibenzodiazepinone-type muscarinic acetylcholine receptor (MR) antagonists, including dimeric ligands, were prepared using red-emitting cyanine dyes.
Xueke She +11 more
semanticscholar +1 more source
Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]
World Journal of Research and Review (WJRR) ISSN:2455-3956,
Volume-4, Issue-5, May 2017 Pages 26-30, 2020 Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv
Synaptic transmission as a cooperative phenomenon in confined systems [PDF]
Condens. Matter Phys., 2017, vol. 20, No. 1, 13804, 2017 In this review paper, the theory of synaptic transmission (ST) was developed and discussed. We used the hypothesis of isomorphism between: (a) the cooperative behavior of mediators --- acetylcholine molecules (ACh) and cholinoreceptors in a synaptic cleft with binding into mediator-receptor (AChR) complexes, (b) the critical phenomena in confined ...
arxiv +1 more source
Activation of nematode G protein GOA‐1 by the human muscarinic acetylcholine receptor M2 subtype
The FEBS Journal, 2006 Signal transduction mediated by heterotrimeric G proteins regulates a wide variety of physiological functions. We are interested in the manipulation of G‐protein‐mediating signal transduction using G‐protein‐coupled receptors, which are derived from ...
M. Minaba +4 more
semanticscholar +1 more source
Journal of Medicinal Chemistry, 2017 The dualsteric ligand approach, aiming at ligands with improved subtype selectivity, has been increasingly applied to muscarinic receptors (MRs). In this article, we present the synthesis and characterization of a M2R subtype-preferring radiolabeled ...
Andrea Pegoli +6 more
semanticscholar +1 more source
Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]
, 2012 The tryptophan metabolite, kynurenic acid (KYNA), is classically known to be an antagonist of ionotropic glutamate receptors. Within the last decade several reports have been published suggesting that KYNA also blocks nicotinic acetylcholine receptors (nAChRs) containing the \alpha7 subunit (\alpha7*).
arxiv +1 more source
Scientific Reports, 2015 Endocytosis and postendocytic sorting of G-protein-coupled receptors (GPCRs) is important for the regulation of both their cell surface density and signaling profile.
M. Wan +6 more
semanticscholar +1 more source
Europace, 2015 AIMS Atrial fibrosis has been found to be associated with recurrent atrial fibrillation (AF) following catheter ablation. Autoantibodies against M2-muscarinic receptors (anti-M2-R) may play a role in the development of AF by inducing left atrial (LA ...
K. Gurses +12 more
semanticscholar +1 more source
A factor graph EM algorithm for inference of kinetic microstates from patch clamp measurements [PDF]
arXiv, 2021 We derive a factor graph EM (FGEM) algorithm, a technique that permits combined parameter estimation and statistical inference, to determine hidden kinetic microstates from patch clamp measurements. Using the cystic fibrosis transmembrane conductance regulator (CFTR) and nicotinic acetylcholine receptor (nAChR) as examples, we perform {\em Monte Carlo}
arxiv
, 1995 The binding of [3H]N-methylscopolarnine ([3H]NMS) to the muscarinic acetylcholine receptor m2 subtype increased and then decreased with the increase of concentration of 9-methoxy-ct-lapachone (LAP), a compound isolated from a medicinal plant Mansoa alli ...
G. Dong, T. Haga, H. Itokawa, F. Mizobe
semanticscholar +1 more source