Results 161 to 170 of about 28,480 (301)
Proceedings of the National Academy of Sciences of the United States of America, 2000 Muscarinic acetylcholine receptors consist of five distinct subtypes and have been important targets for drug development. In the periphery, muscarinic acetylcholine receptors mediate cholinergic signals to autonomic organs, but specific physiological ...
M. Matsui +7 more
semanticscholar +1 more source
Endocrine and Metabolic ScienceThe interaction of nutrients and bacterial-derived products and their enteroendocrine effects are still enigmatic. We used the human enteroendocrine tumour cell line P-STS isolated from the terminal ileum as cellular sentinel.
Beatrix Pfanzagl, Erika Jensen-Jarolim
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Effects of Nerve Growth Factor shRNA Inhibition on Asthma Phenotypes in a Mouse Model of Asthma
Iranian Journal of Allergy, Asthma and Immunology, 2018 Nerve growth factor (NGF) plays an important role in airway hyper-responsiveness (AHR). In this study, we aimed at investigating the effect of NGF inhibition on AHR and other asthma phenotypes in a mouse model of asthma.
Jinhong Wu +3 more
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The surface accessibility of α-bungarotoxin monitored by a novel paramagnetic probe [PDF]
arXiv, 2011 The surface accessibility of {\alpha}-bungarotoxin has been investigated by using Gd2L7, a newly designed paramagnetic NMR probe. Signal attenuations induced by Gd2L7 on {\alpha}-bungarotoxin C{\alpha}H peaks of 1H-13C HSQC spectra have been analyzed and compared with the ones previously obtained in the presence of GdDTPA-BMA. In spite of the different
arxiv
Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]
arXiv, 2017 We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration, and effective Hill coefficient, and explore the full spectrum
arxiv
Brain, Behavior, & Immunity - Health, 2020 Myalgic encephalomyelitis (ME) also known as ME/CFS (Chronic Fatigue Syndrome) or ME/SEID (Systemic Exertion Intolerance Disorder), is a disabling and often long-lasting disease that can drastically impair quality of life and physical/social functioning ...
Annie Bynke +5 more
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Identification of a Basolateral Sorting Signal for the M3 Muscarinic Acetylcholine Receptor in Madin-Darby Canine Kidney Cells [PDF]
, 2001 Laurie S. Nadler +2 more
openalex +1 more source
Growth inhibition by the muscarinic M3 acetylcholine receptor: evidence for p21Cip1/Waf1 involvement in G1 arrest [PDF]
, 2002 D. Burdon +3 more
openalex +1 more source
, 2023 The human M3 muscarinic acetylcholine receptor (M3R) regulates many important physiological roles in the central and peripheral nervous systems, and it is involved in the pathophysiology of several neurodegenerative and autoimmune diseases, representing attractive potential pharmacological target for intervention.
openaire +4 more sources
Journal of Pharmaceutical Analysis, 2021 Diarrhea is a prevalent gastrointestinal problem associated with fatal implications. It is a huge public health concern that requires better alternatives to current drugs.
Blessing O. Omolaso +5 more
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