Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk
MedComm, Volume 5, Issue 11, November 2024.The figure depicts the intricate interactions between cancer cells, the immune system, and nerves within the tumor microenvironment. At the center, the diagram highlights the tripartite relationship among cancer, immune, and nerve cells, illustrating the dynamic and reciprocal influences they exert on one another.
Hua‐Yang Fan +2 more
wiley +1 more source
Boundary lipids of the nicotinic acetylcholine receptor: spontaneous partitioning via coarse-grained molecular dynamics simulation [PDF]
arXiv, 2018 Reconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function upon addition of cholesterol to reconstitution mixtures, and cholesterol affects organization of nAChRs within domain-forming membranes, but whether nAChR partitions to cholesterol-rich liquid-ordered ("raft" or $l_o$) domains or cholesterol-poor liquid ...
arxiv
Urothelium muscarinic activation phosphorylates CBS Ser227 via cGMP/PKG pathway causing human bladder relaxation through H 2 S production [PDF]
, 2016 The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H2S as possible mediator released downstream following muscarinic (M) activation, by using human ...
CIRINO, GIUSEPPE +10 more
core +1 more source
Opening a hydrophobic gate: the nicotinic acetylcholine receptor as an example [PDF]
arXiv, 2009 To what extent must a hydrophobic gate expand for the channel to count as open? We address this question using the nicotinic acetylcholine receptor (nAChR) as the exemplar. The nAChR is an integral membrane protein which forms a cation selective channel gated by neurotransmitter binding to its extracellular domain.
arxiv
3-iodothyronamine (T1AM), a novel antagonist of muscarinic receptors. [PDF]
, 2016 3-iodothyronamine (T1AM) is a trace amine suspected to derive from thyroid hormone metabolism. T1AM was described as a ligand of G-protein coupled monoaminergic receptors, including trace amine associated receptors, suggesting the amine may exert a ...
Laurino, Annunziatina +3 more
core +1 more source
Enhanced muscarinic M1 receptor gene expression in the corpus striatum of streptozotocin-induced diabetic rats [PDF]
, 2009 Acetylcholine (ACh), the first neurotransmitter to be identified, regulate the activities of central and peripheral functions through interactions with muscarinic receptors. Changes in muscarinic acetylcholine receptor (mAChR) have been implicated in the
Gireesh, G +3 more
core +3 more sources
Assessing the clinical value of fast onset and sustained duration of action of long-acting bronchodilators for COPD [PDF]
, 2015 Date of Aceptance: 12/02/2015 Acknowledgments The authors were assisted in the preparation of the manuscript by Sarah Filcek, a professional medical writer at CircleScience (Tytherington, UK), part of KnowledgePoint360, an Ashfield Company.
Beeh, Kai M +3 more
core +1 more source
ACS Chemical Neuroscience, 2019 Opioid Use Disorder (OUD) is a debilitating neuropsychiatric condition characterized by compulsive opioid use, dependence, and repeated relapse after periods of abstinence.
R. Gould +10 more
semanticscholar +1 more source
Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics [PDF]
Journal of Computational Neuroscience 24, 253-276 (2008), 2007 To establish the relationship between locomotory behavior and dynamics of neural circuits in the nematode C. elegans we combined molecular and theoretical approaches. In particular, we quantitatively analyzed the motion of C. elegans with defective synaptic GABA and acetylcholine transmission, defective muscle calcium signaling, and defective muscles ...
arxiv
M1 muscarinic receptor for the development of auditory cortical function [PDF]
, 2010 The sensory cortex is subject to continuous remodelling during early development and throughout adulthood. This process is important for establishing normal brain function and is dependent on cholinergic modulation via muscarinic receptors.
Shideler, Karalee K, Yan, Jun
core +3 more sources