Results 101 to 110 of about 2,691 (151)

Acetylcholine in the hippocampus: problems and achievements. [PDF]

Front Neural Circuits
Dobryakova YV, Bolshakov AP, Korotkova T, Rozov AV.   +3 more
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Investigation of the mechanism of Yijing Decoction in the treatment of premature ovarian insufficiency: A network pharmacology study. [PDF]

Biochem Biophys Rep
Xu Y, Zhao X, Yu W, Zhang P, Cheng Z, Yang L, Zhou H.   +6 more
europepmc   +1 more source

Selective modulation of murine intestinal M₁ and M₃ muscarinic receptor expression has divergent effects on specialized epithelial cells and body weight. [PDF]

Am J Physiol Cell Physiol
Sampaio Moura N, Schledwitz A, Cheng K, Song Y, Kwon MS, Cairns CA, Njei LP, Raufman B, Drachenberg CB, Wang JY, Ma B, Raufman JP.   +11 more
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Characterization of Selective M5 Acetylcholine Muscarinic Receptor Modulators on Dopamine Signaling in the Striatum

The Journal of Pharmacology and Experimental Therapeutics, 2023
The type-5 muscarinic acetylcholine receptor (mAChR, M5) is almost exclusively expressed in dopamine (DA) neurons of the ventral tegmental area and substantia nigra pars compacta; therefore, they are ideally located to modulate DA signaling and underlying behaviors. However, the role of M5 in shaping DA release is still poorly characterized.
Vivien Zell, Greetje Teuns, Alexandra Stormy Needham, Sruti Mukherjee, Nathaniel Roscoe, Michelle Le, Lawrence Fourgeaud, Grace Woodruff, Anindya Bhattacharya, Mathieu Marella, Pascal Bonaventure, Wayne C. Drevets, Bartosz Balana   +12 more
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Functional expression of rat M5 muscarinic acetylcholine receptor in yeast

Biochemical and Biophysical Research Communications, 1992
We have produced the rat M5 muscarinic acetylcholine receptor, an integral membrane protein, in the yeast Saccharomyces cerevisiae. This was achieved by placing an M5 gene in the yeast vector under the control of the yeast alpha-factor promoter and leader sequence.
Huang, Hao-Jen, Liao, Ching-Fong, Yang, Bei-Chang, Kuo, Tsong-Ten   +3 more
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Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

Neuron, 1988
The human and rat genes for a fifth muscarinic receptor have been cloned and expressed in mammalian cells. The 532 amino acid human protein has 89% sequence identity to the 531 amino acid rat protein and is most closely related to the m3 receptor. Both proteins are encoded by single exons.
T I, Bonner, A C, Young, M R, Brann, N J, Buckley   +3 more
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Characterization of methanthelinium binding and function at human M1–M5 muscarinic acetylcholine receptors

Naunyn-Schmiedeberg's Archives of Pharmacology, 2018
Firstly, it was determined whether methanthelinium bromide (MB) binds to human M1-M5 (hM1-hM5) muscarinic acetylcholine receptors in comparison to the classical muscarinic antagonist N-methylscopolamine (NMS). [3H]NMS dissociation binding experiments revealed an allosteric retardation of dissociation at 100 μM of MB ranging from none in hM3 to 4.6-fold
Matthias Irmen, Janine Holze, Theresa Bödefeld, Christian Tränkle   +3 more
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Intramolecular interactions in muscarinic acetylcholine receptors studied with chimeric m2/m5 receptors.

Molecular Pharmacology, 1994
Current models of the three-dimensional structures of muscarinic acetylcholine receptors and other G protein-coupled receptors are based primarily on high-resolution electron diffraction data obtained with bacteriorhodopsin, the molecular structure of which is characterized by the presence of seven alpha-helical transmembrane domains (TM I-VII ...
Z, Pittel, J, Wess
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