Results 81 to 90 of about 1,293,750 (146)

Identification of m3, m4 and m5 subtypes of muscarinic receptor mRNA in human blood mononuclear cells

, 1995
In this study we made use of the Reverse transcription-polymerase chain reaction to analyze the expression of mRNA for the five subtypes of muscarinic acetylcholine receptors in human blood mononuclear cells. mRNA for m3, m4 and m5 subtypes was detected,
Costa, L. G., Costa, P, Traver, D. J, Auger, C. B   +3 more
core  

Discovery, Optimization, and Characterization of Novel Subtype-Selective Muscarinic Acetylcholine Receptor M4 and M5 Positive Allosteric Modulators

, 2010
There exist five subtypes of the muscarinic acetylcholine receptor (M1-M5), which are differentially expressed throughout the body and play important roles in numerous physiological processes, including autonomic functions, motor control, cognition ...
Bridges, Thomas Miller
core  

The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation [PDF]

, 2005
Background— The molecular mechanism of increased background inward rectifier current (IK1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active acetylcholine (ACh)-activated IK,ACh contributes to enhanced basal ...
Ravens, U., Wettwer, E., Christ, T., Voigt, N., Friedrich, A., Knaut, M., Jost, Norbert, Dobrev, D.   +7 more
core  

Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor

The M1 muscarinic acetylcholine receptor (M1R) is highly expressed in the nervous system, and has been studied to discover new therapeutic drugs for a range of neurological and psychiatric disorders.
Amiri, Shayan
core  

Muscarinic M2 acetylcholine receptor distribution in the guinea-pig gastrointestinal tract [PDF]

In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells.
NOJYO, Yoshiaki, IINO, Satoshi
core  

Discovery, Optimization, and Characterization of Novel Subtype-Selective M5 Muscarinic Acetylcholine Receptor Ligands

, 2014
The muscarinic acetylcholine receptors (mAChRs) are a family of G protein-coupled receptors comprised of five subtypes (M1-5) expressed throughout the central nervous system (CNS).
Gentry, Patrick Ryan
core  

Design and synthesis of potential M1 muscarinic acetylcholine receptor dualsteric modulator

, 2015
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Inorganic and Organic chemistry Consultant: Prof. Dr. Ulrike Holzgrabe, PharmDr. Jaroslav Roh, Ph.D. Student: Petr Průša Title of Thesis: Design and synthesis of potential
Průša, Petr
core  

Muscarinic Receptor PET in Neurodegeneration: Promise, Pitfalls, and Translational Priorities. [PDF]

Med Sci (Basel)
Filippi L, Danieli R.
europepmc   +1 more source

Xanomeline-Trospium Validates Muscarinic Agonism as an Effective Non-Dopaminergic Treatment for Schizophrenia. [PDF]

Int J Mol Sci
Mansour GK, Hajjar AW, Hajjar AH, Alissa A, Sukkarieh HH.   +4 more
europepmc   +1 more source

Viral Induced Hypersecretion of Mucous (VIper): Proposal for a Distinct Phenotype of Viral Induced Lower Respiratory Tract Infection in Children. [PDF]

Pediatr Pulmonol
Massie J, Baenziger O.
europepmc   +1 more source