Muscarinic M2 acetylcholine receptor distribution in the guinea-pig gastrointestinal tract [PDF]
In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells.
NOJYO, Yoshiaki, IINO, Satoshi
core +1 more source
Muscarinic acetylcholine receptor M5 is involved in spermatogenesis through the modification of cell-cell junctions. [PDF]
Han X +9 more
europepmc +1 more source
The m5 muscarinic receptor: Labeling and localization studies
The aims of this study were: (1) to develop binding conditions that labeled predominantly the m5 muscarinic receptor subtype; (2) to use m5-selective labeling conditions to study the distribution of the m5 receptor subtype in the rat brain and make ...
Reever, Carolyn
core +3 more sources
Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]
Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven ...
Kühne, Sina +9 more
core +1 more source
The actions of Pasteurella multocida toxin on neuronal cells [PDF]
Pasteurella multocida toxin (PMT) activates the G-proteins Gα, Gα, Gα Gα and Gα by deamidation of specific glutamine residues. A number of these alpha subunits have signalling roles in neurones.
Lax, Alistair; id_orcid +13 more
core +1 more source
a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist
Previous work from our laboratory indicates that bile acids, specifically lithocholic acid conjugates, interact with muscarinic receptors on gastric chief cells.
Kunrong Cheng +5 more
core
Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors [PDF]
GABA(A) receptors are the principal sites of fast synaptic inhibition in the brain. These receptors are hetero-pentamers that can be assembled from a number of subunit classes: alpha(1-6), beta(1-3), gamma(1-3), delta(1), epsilon, theta, and pi, but the ...
Trevor G Smart +7 more
core
RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Bötzinger complex
Muscarinic receptors mediate the postsynaptic excitatory effects of acetylcholine (ACh) on inspiratory neurons in the pre-Bötzinger complex (pre-BötC), the hypothesized site for respiratory rhythm generation.
Cindy H. Huang +5 more
core +1 more source
Morphine-induced Locomotion Increases following Viral Transfection of M5 Muscarinic Receptor Genes in the Ventromedial Hypothalamus of Wild-type Mice [PDF]
Excitatory M5 muscarinic acetylcholine receptors are expressed at the highest level in the brain, in the ventromedial hypothalamus (VMH). M5 knockout (KO) mice emit fewer ultrasonic vocalizations (USVs) during mating, and show 40-50% lesser morphine ...
Nawaz, Sabrina
core +2 more sources
M1 muscarinic acetylcholine receptor in Alzheimer's disease
The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5 ...
Li, Yanfang +6 more
core +1 more source

