The surface accessibility of α-bungarotoxin monitored by a novel paramagnetic probe [PDF]
arXiv, 2011 The surface accessibility of {\alpha}-bungarotoxin has been investigated by using Gd2L7, a newly designed paramagnetic NMR probe. Signal attenuations induced by Gd2L7 on {\alpha}-bungarotoxin C{\alpha}H peaks of 1H-13C HSQC spectra have been analyzed and compared with the ones previously obtained in the presence of GdDTPA-BMA. In spite of the different
arxiv
Expression of functional M2 muscarinic acetylcholine receptor in Escherichia coli [PDF]
, 2000 The M2 muscarinic acetylcholine receptor mutant (M2 mutant), with a lack of glycosylation sites, a deletion in the central part of the third inner loop, and the addition of a six histidine tag at the C-terminus, was fused to maltose binding protein (MBP)
Furukawa, H., Haga, T.
core +1 more source
Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]
arXiv, 2017 We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration, and effective Hill coefficient, and explore the full spectrum
arxiv
Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection
Pharmacological ResearchΔ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova +2 more
doaj
Human HT-29 colon carcinoma cells contain mucarinic M\(_3\) receptors coupled to phosphoinositide metabolism [PDF]
, 1989 Five different musearlnie receptor subtypes ean be distinguished by the differenees in their amino aeid sequence, the eoupled signal transduetion system, pharmaeologieal binding properties and aetivation of ionie fluxes.
Kopp, R. +5 more
core
ACS Chemical Neuroscience, 2018 Recent years have seen a large increase in the discovery of allosteric ligands targeting muscarinic acetylcholine receptors (mAChRs). One of the challenges in screening such compounds is to understand their mechanisms of action and define appropriate ...
Alice E. Berizzi +6 more
semanticscholar +1 more source
A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor [PDF]
, 2010 Muscarinic acetylcholine receptors (MRs), a family of five G protein-coupled receptors (GPCRs), play an essential role in the regulation of mammalian physiology.
Bendor, Jacob T.
core +1 more source
Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimerâs disease [PDF]
arXiv, 2019 The tight coupling between neuronal activity and the local increase of blood flow termed neurovascular coupling is essential for normal brain function. This mechanism of regulation is compromised in Alzheimer's Disease (AD). In order to determine whether a purely vascular dysfunction or a neuronal alteration of blood vessels diameter control could be ...
arxiv
Expression of muscarinic receptor subtypes in tree shrew ocular tissues and their regulation during the development of myopia [PDF]
, 2009 Muscarinic receptors are known to regulate several important physiologic processes in the eye. Antagonists to these receptors such as atropine and pirenzepine are effective at stopping the excessive ocular growth that results in myopia.
Cottriall, C.L. +4 more
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