Results 71 to 80 of about 5,170 (209)

Expression and function of G-protein-coupled receptorsin the male reproductive tract [PDF]

, 2009
This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract.
ABOUD R, ALONSO-LLAMAZARES A, ANAND-IVELL RJ, ANDERSON MB, BAN Y, BATHGATE RA, BATHGATE RA, BERNARD V, BERNARD V, BHATHAL PS, BIRDSALL NJ, BISHOP MJ, BLANCO M, BOGIC L, BORGES MOR, BRADDON SA, BRODDE OE, BURAZIN TC, BURT RP, BURT RP, CAMPOS M, Catarina S. Porto, CAULFIELD MP, CHALOTHORN D, CHAN HC, CHANG DJ, CHATURAPANICH G, CHEAH SH, CHEN S, CHEN S, COGÉ F ET AL, DA SILVA MC, DALY CJ, DANIELS DV, DAVENPORT CW, DEBRUYNE FM, DENG XF, DIVIANI D, DOCHERTY JR, DOCHERTY JR, DOGGRELL SA, DU JY, EGLEN RM, EGLEN RM, EHRÉN I, EISENHOFER G, ERRASTI AE, ESBENSHADE TA, ESSIG M, FENG S, FEVOLD HL, FILONZI M, FORD APDW, FORD APDW, FORRAY C, FUKASAWA R, GAO B, GAO B, GOBEIL F JR, GONZÁLEZ-ESPINOSA C, GRAHAM RM, GRIMM U, GUNNERSEN JM, GUNNERSEN JM, HAAG C, HAGUE C, HAGUE C, HALLS ML, HALLS ML, HALLS ML, HAMAMURA M, HANFT G, HANSELL DJ, HAUSER F, HAWRYLYSHYN KA, HEIN P, HIB J, HIB J, HIEBLE JP, HIEBLE JP, HIRASAWA A, HIRASAWA A, HIRASAWA A, HISAW FL, HOMMA Y, HORIE K, HROMETZ SL, HSU SY, HSU SY, HU K, HULEIHEL M, HULME EC, HWA J, HWA J, HWA J, II M, IRAM S, IVELL R, IVELL R, JACKSON VM, JEYABALAN A, JEYABALAN A, JIANG X, JOCKENHOVEL F, JUDSON DG, JURKIEWICZ NH, KAMAT AA, KARKANIAS GB, KERN A, KIM JK, KINGHORN EM, KOHSAKA T, KONDO S, KRAJNC-FRANKEN MA, KUBO T, KUDO M, LACEY JP, LANGER S, LANZAFAME AA, LAU WA, LAZ TM, LEEB-LUNDBERG LM, LEFKOWITZ RJ, LEFKOWITZ RJ, LEFKOWITZ RJ, LENHART JA, LEPOR H, LEUNG AYH, LIU C, LOCKWOOD DH, LONGHURST PA, LOPEZ-GIMENEZ JF, LUCAS TFG, LUCAS TFG, LUTHIN GR, MACDONALD A, MACKENZIE JF, MACKINNON AC, MALLARD NJ, MANNI L, MANNI L, Maria Christina W. Avellar, Maria Fatima M. Lázari, MARKUS RP, MARÓSTICA E, MARÓSTICA E, MCCUNE DF, MCCUNE SK, MENDES FR, MICHELOTTI GA, MICHELOTTI GA, MIRANDA HF, MIRANDA HF, MIRANDA HF, MOOKERJEE I, MORIYAMA N, MORROW AL, MURAMATSU I, MURRAY KT, NADELHAFT I, NAKAOKA H, NASU K, NASU K, NEWINGER J, NISHIS, NOTHACKER HP, OBARA K, PAPATSORIS AG, PATRÃO MT, PEDRETTI A, PEREZ DM, PETITTI N, PIASCIK MT, PIASCIK MT, PIASCIK MT, PONTARI MA, PORTER JE, PRENZEL N, PRICE DT, PRICE DT, PRICE RR, PUPO AS, PUPO AS, QUEIRÓZ DB, QUEIRÓZ DBC, QUESADA A, RAMARAO CS, RAMSAY D, RATNASOORIYA WD, RATNASOORIYA WD, RAYFORD W, RICKER DD, ROEHRBORN CG, ROKOSH DG, ROKOSH DG, RUDNER XL, RUFFOLO RR JR, RUGGIERI MR, SALAMANCA AE, SALLÉS J, SAMUEL CS, SAMUEL CS, SAMUEL CS, SANBE A, SANBORN BM, SAROSI P, SATO T, SAUSSY DL JR, SAWUTZ DG, SCARPARO AC, SCHWINN DA, SCHWINN DA, SCOFIELD MA, SCOTT DJ, SCOTT DJ, SHANNON HE, SHAPIRO E, SHEN H, SHERWOOD OD, SHIMA S, SHINOURA H, SILVA MA, SIU ER, SKINNER MK, SOKOL RZ, STEINETZ BG, SUDO S, SUGAWARA T, SUZUKI F, TAYEBATI SK, TENG CM, TENSEN CP, TESTA R, THEBAULT S, THEROUX TL, TOEWS ML, UBERTI MA, UBERTI MA, VAN DIJK MM, VAN KOPPEN CJ, VARMA DR, VENTURA S, VICENTIC A, VIVAS NM, VÁZQUEZ-PRADO J, WALDEN PD, WALKER WH, WANG JM, WANG X ET AL, WAUGH DJ, WESS J, WIER WG, XIAO L, XU Z, YAN HH, YANG M, YANG-FENG TL, YANG-FENG TL, YASUOKA A, YAZAWA H, YAZAWA H, YKI-JARVINEN H, YOSHINAGA T, ZHAO L, ZHONG H, ZHONG H, ZIMMERMANN S, ZUSCIK MJ   +267 more
core   +3 more sources

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life [PDF]

, 2012
Protein restriction during lactation has been used as a rat model of metabolic programming to study the impact of perinatal malnutrition on adult metabolism.
Clarice Gravena, Júlio de Oliveira, Paulo Cezar de Mathias, Sabrina Grassiolli   +3 more
core   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Repositioning VU‐0365114 as a novel microtubule‐destabilizing agent for treating cancer and overcoming drug resistance

Molecular Oncology
Microtubule‐targeting agents represent one of the most successful classes of anticancer agents. However, the development of drug resistance and the appearance of adverse effects hamper their clinical implementation.
Yao‐Yu Hsieh, Jia‐Ling Du, Pei‐Ming Yang   +2 more
doaj   +1 more source

A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization. [PDF]

, 2010
BACKGROUND: G protein-coupled receptors (GPCRs) represent a family of well-characterized drug targets with significant therapeutic value. Phylogenetic classifications may help to understand the characteristics of individual GPCRs and their subtypes ...
Bender, Andreas, Beukers, Margot W, Emmerich, Michael TM, Ijzerman, Adriaan P, Lane, Jonathan R, Okuno, Yasushi, Peironcely, Julio E, van der Horst, Eelke, van Vlijmen, Herman WT   +8 more
core   +4 more sources

Deletion of the M ₅ muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia [PDF]

Proceedings of the National Academy of Sciences, 2002
Little is known about the physiological roles of the M 5 muscarinic receptor, the last member of the muscarinic receptor family (M 1 –M 5 ) to be cloned. In the brain, the M 5 receptor subtype is preferentially expressed by dopaminergic neurons ...
Anthony S, Basile, Irina, Fedorova, Agustin, Zapata, Xiaoguang, Liu, Toni, Shippenberg, Alokesh, Duttaroy, Masahisa, Yamada, Jurgen, Wess   +7 more
openaire   +2 more sources

Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions

Ibrain, Volume 11, Issue 2, Page 162-184, Summer 2025.
Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra, Reena Rani Nayak, Ankit Ganeshpurkar, Prashant Tiwari, Dileep Kumar   +4 more
wiley   +1 more source

Acetylcholine induces fibrogenic effects via M2/M3 ACh receptors in NASH and in primary human hepatic stellate cells [PDF]

, 2016
BACKGROUND: The parasympathetic nervous system (PNS), via neurotransmitter Acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear.
Cordero, P, McKee, C, Morgan, ML, Mouraliderane, A, Nguyen, V, Oben, JA, Sigala, B, Soeda, J, Vinciguerra, M   +8 more
core  

Urothelium muscarinic activation phosphorylates CBS Ser227 via cGMP/PKG pathway causing human bladder relaxation through H 2 S production [PDF]

, 2016
The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H2S as possible mediator released downstream following muscarinic (M) activation, by using human ...
CIRINO, GIUSEPPE, D'EMMANUELE DI VILLA BIANCA, ROBERTA, DONNARUMMA, ERMINIA, FUSCO, FERDINANDO, MIRONE, VINCENZO, MITIDIERI, EMMA, Pagliara, Valentina, RUSSO, ANNAPINA, RUSSO, GIULIA, SORRENTINO, RAFFAELLA, Tramontano, Teresa   +10 more
core   +1 more source