Results 71 to 80 of about 13,887 (182)

Muscarinic receptor blockade with oxybutynin reduces spontaneous and induced uterine muscle contractions

Pregnancy, Volume 1, Issue 1, January 2025.
Abstract Objective The uterus and the bladder have striking physiologic and anatomic similarities. Anticholinergic medications are commonly used to treat “overactive bladder” by targeting M2 and M3 muscarinic receptors. The uterus also contains M2 and M3 muscarinic receptors; however, current management of preterm labor does not target these receptors.
Anthony G. Visco, Zachary R. Visco, Chad A. Grotegut, Cristina Linde, Timothy Westfall, Friederike L. Jayes   +5 more
wiley   +1 more source

Anticholinergic drugs and dementia risk: Using stem cell–based studies to complement pharmacoepidemiology

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 11, Issue 1, January-March 2025.
Abstract BACKGROUND Anticholinergic (AC) use remains common in older adults despite evidence of safety risks, including increased risk in dementia. Pharmacoepidemiology studies from various populations report associations between specific anticholinergic classes – antidepressants and bladder antimuscarinics – and increased dementia incidence.
Tiara A. Schwarze‐Taufiq, Inez K. A. Pranoto, Katherine Hui, Chizuru Kinoshita, Onchee Yu, Paul K. Crane, Shelly L. Gray, Jessica E. Young   +7 more
wiley   +1 more source

In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF1 receptor in cardiorespiratory impairment

British Journal of Pharmacology, Volume 182, Issue 1, Page 104-130, January 2025.
Abstract Background and Purpose Fentanyl analogues have been implicated in many cases of intoxication and death with overdose worldwide. The aim of this study is to investigate the pharmaco‐toxicology of two fentanyl analogues: butyrylfentanyl (BUF) and 4‐fluorobutyrylfentanyl (4F‐BUF).
Sabrine Bilel, Joaquim Azevedo Neto, Micaela Tirri, Giorgia Corli, Marta Bassi, Anna Fantinati, Giovanni Serpelloni, Davide Malfacini, Claudio Trapella, Girolamo Calo', Matteo Marti   +10 more
wiley   +1 more source

The Fatal Mushroom Neurotoxin Muscarine is Released from a Harmless Phosphorylated Precursor upon Cellular Injury

Angewandte Chemie International Edition, Volume 63, Issue 52, December 20, 2024.
l‐(+)‐Muscarine is one of the most toxic mushroom metabolites. We identified its congener 4’‐phosphomuscarine in the fool's funnel and in various fiber cap mushrooms, and chemically and pharmacologically characterized this new natural product. As hydrolysis of its ester releases muscarine, our results help estimate the true toxin content of these ...
Sebastian Dörner, Felix Trottmann, Paul M. Jordan, Kai Rogge, Benjamin Bartels, Oliver Werz, Christian Hertweck, Dirk Hoffmeister   +7 more
wiley   +1 more source

Advancing Neural Networks: Innovations and Impacts on Energy Consumption

Advanced Electronic Materials, Volume 10, Issue 12, December 2024.
A comparative study of ANN and SNN including biological neural networks is presented. An inefficiency of 5–8 orders of magnitude is indicated for modern ANN approaches, with the worst Transformer ANN over CPU. The most efficient implementation of the SNNs is biological neurons with only 100 fJ per synaptic weight update, next is inorganic Mosaic ...
Alina Fedorova, Nikola Jovišić, Jordi Vallverdù, Silvia Battistoni, Miloš Jovičić, Milovan Medojević, Alexander Toschev, Evgeniia Alshanskaia, Max Talanov, Victor Erokhin   +9 more
wiley   +1 more source

Photo‐BQCA: Positive Allosteric Modulators Enabling Optical Control of the M1 Receptor

Angewandte Chemie International Edition, Volume 63, Issue 47, November 18, 2024.
Photoswitchable allosteric modulators for the Class A of a G protein‐coupled receptor, themuscarinic acetylcholine receptor subtype 1 (M1R) were developed based on the allosteric modulator benzyl quinolone carboxylic acid (BQCA) exploiting its flat structure–activity relationships.
Hubert Gerwe, Eva Schaller, Rosalba Sortino, Ekin Opar, Joaquín Martínez‐Tambella, Marcel Bermudez, J. Robert Lane, Pau Gorostiza, Michael Decker   +8 more
wiley   +1 more source

Acute Negative Allosteric Modulation of M5 Muscarinic Acetylcholine Receptors Inhibits Oxycodone Self-Administration and Cue-Induced Reactivity with no effect on Antinociception.

ACS Chemical Neuroscience, 2019
Opioid Use Disorder (OUD) is a debilitating neuropsychiatric condition characterized by compulsive opioid use, dependence, and repeated relapse after periods of abstinence.
R. Gould, Barak W. Gunter, M. Bubser, R. Matthews, Laura B. Teal, Madeline G Ragland, T. Bridges, Aaron T Garrison, D. Winder, C. Lindsley, Carrie K Jones   +10 more
semanticscholar   +1 more source

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj  

Structure-Activity Relationships of Pan-Gαq/11 Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators.

ACS Chemical Neuroscience, 2018
Recent years have seen a large increase in the discovery of allosteric ligands targeting muscarinic acetylcholine receptors (mAChRs). One of the challenges in screening such compounds is to understand their mechanisms of action and define appropriate ...
Alice E. Berizzi, Aaron M. Bender, C. Lindsley, P. J. Conn, P. Sexton, C. Langmead, A. Christopoulos   +6 more
semanticscholar   +1 more source

Acetylcholine Increases the Free Intracellular Calcium Concentration in Podocytes in Intact Rat Glomeruli via Muscarinic M5 Receptors [PDF]

, 2001
Roland Nitschke, Anna Henger, Sigrid Ricken, VICTORIA MUCombining DiaeresisLLER, MICHAEL KOCombining DiaeresisTTGEN, Martin J. Bek, Hermann PavenstaCombining Diaeresisdt   +6 more
openalex   +1 more source