Muscarinic Receptor Agonists and Antagonists [PDF]
Molecules, 2001 A comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the ...
David R. Kelly, Kenneth J. Broadley
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Is muscarinic receptor agonist effective and tolerant for schizophrenia? [PDF]
BMC PsychiatryBackground Several randomized clinical trials (RCTs) have recently examined the efficacy and tolerability of muscarinic receptor agonists in schizophrenia. However, whether therapeutics targeting muscarinic receptors improve symptom management and reduce
Xiaonan Guo +3 more
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Multitargeting nature of muscarinic orthosteric agonists and antagonists
Frontiers in Physiology, 2022 Muscarinic receptors (mAChRs) are typical members of the G protein-coupled receptor (GPCR) family and exist in five subtypes from M1 to M5. Muscarinic receptor subtypes do not sufficiently differ in affinity to orthosteric antagonists or agonists ...
Jaromir Myslivecek
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Downstream Signaling of Muscarinic M4 Receptors Is Regulated by Receptor Density and Cellular Environment [PDF]
Pharmacology Research & PerspectivesMultiple muscarinic M4 receptor modulators are currently advancing in clinical development for the treatment of positive symptoms in schizophrenia, including agonists and positive allosteric modulators.
Madeleine Merz +5 more
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Therapeutic Strategies in Alzheimer’s Disease: Ml Muscarinic Agonists
Japanese Journal of Pharmacology, 2000 The cholinergic hypofunction in Alzheimer's disease (AD) appears to be linked with two other major hallmarks of this disease, beta-amyloid and hyperphosphorylated tau protein.
Abraham Fisher
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Muscarinic agonists block five different potassium conductances in guinea‐pig sympathetic neurones [PDF]
British Journal of Pharmacology, 1987 J F Cassell, Elspeth M. McLachlan
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Importance and prospects for design of selective muscarinic agonists
Physiological Research, 2008 There are five subtypes of muscarinic receptors that serve various important physiological functions in the central nervous system and the periphery. Mental functions like attention, learning, and memory are attributed to the muscarinic M1 subtype. These functions decline during natural aging and an early deficit is typical for Alzheimer s disease.
Ján Jakubík +3 more
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Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons [PDF]
Molecular MetabolismObjective: Antagonism of the muscarinic acetylcholine type 1 receptor (M1R) promotes sensory axon repair and is protective in peripheral neuropathy, however, the mechanism remains elusive.
Sanjana Chauhan +6 more
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Muscarinic and nicotinic acetylcholine receptor agonists: current scenario in Alzheimer's disease therapy [PDF]
The Journal of pharmacy and pharmacology, 2018 Stuti Verma +3 more
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Combination therapy with β3‐adrenoceptor agonists and muscarinic acetylcholine receptor antagonists: Efficacy in rats with bladder overactivity [PDF]
International journal of urology, 2016 Akira Furuta +5 more
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