Results 121 to 130 of about 496,043 (271)

Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 832-853, March 2026.
ABSTRACT Background Functional dyspepsia (FD) is a common gastrointestinal disorder that significantly impacts patients' quality of life. Over a decade ago, the Asian Neurogastroenterology and Motility Association (ANMA) and the Asian Pacific Association of Gastroenterology (APAGE) jointly developed the first Asian consensus report on FD.
Sanjiv Mahadeva, Kewin Tien Ho Siah, Uday C. Ghoshal, Hidekazu Suzuki, Yeong Yeh Lee, Kee Huat Chuah, Vincent Chung, Linda Zhong, Benjamin Wei‐Rong Tay, Ban Hong Ang, Ram Prasad Sinnanaidu, Tao Bai, Tadayuki Oshima, Tanisa Patcharatrakul, Sanjeev Sachdeva, Ping‐Huei Tseng, Jinsong Liu, Yinglian Xiao, Ratha‐Korn Vilaichone, Joon Seong Lee, Jung‐Hwan Oh, Ari Fahrial Syam, Ching Liang Lu, Tiing Leong Ang, In‐Kyung Sung, Xiao‐Hua Hou, Kentaro Sugano, Justin Wu, Hiroto Miwa   +28 more
wiley   +1 more source

Pharmacokinetics and Safety of a Single Subcutaneous or Intramuscular Dose of Ketamine in Healthy Horses

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 2, Page 141-149, March 2026.
ABSTRACT Pharmacokinetics (PK) of intramuscular (IM) and subcutaneous (SC) ketamine in horses has not been described. This study aimed to evaluate the PK and safety of ketamine and its metabolites after a single SC or IM administration. In Phase 1, two horses received 0.5 or 1 mg/kg of ketamine via SC and IM routes.
Ana Rangel, Debra C. Sellon, Macarena G. Sanz, Erin Pinnell, Zuzanna M. Pietras, Nicolas F. Villarino   +5 more
wiley   +1 more source

Differential pharmacology and clinical utility of emerging combination treatments in the management of COPD – role of umeclidinium/vilanterol

International Journal of COPD, 2014
Mario Malerba,1 Jaymin Bhagwanji Morjaria,2 Alessandro Radaeli3 1Department of Internal Medicine, University of Brescia, Brescia, Italy; 2Department of Academic Respiratory Medicine, Hull York Medical School, University of Hull, Castle Hill Hospital ...
Malerba M, Morjaria JB, Radaeli A
doaj  

Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons

Molecular Metabolism
Objective: Antagonism of the muscarinic acetylcholine type 1 receptor (M1R) promotes sensory axon repair and is protective in peripheral neuropathy, however, the mechanism remains elusive.
Sanjana Chauhan, Darrell R. Smith, Shiva Shariati-Ievari, Abhay Srivastava, Sanjiv Dhingra, Michel Aliani, Paul Fernyhough   +6 more
doaj   +1 more source

Gatherings in Esophagology: Innovations and Future Directions in the Diagnosis and Management of Reflux Disease

Annals of the New York Academy of Sciences, Volume 1557, Issue 1, March 2026.
Bringing together experts in reflux diseases, including gastroenterologists, surgeons, endoscopists, laryngologists, pulmonologists, and research scientists, the inaugural Gatherings in Esophagology (GiE) was held May 30–31, 2025, in France as a new initiative of Organisation mondiale d'Etudes Spécialisées pour les maladies de l'Oesophage (OESO).
Jennifer Cable, Robert Giuli, Mark R. Fox, Rachel L. Rosen, Luis R. Valdovinos‐García, Stefano Siboni, John O. Clarke, Nikki Johnston, Tina L. Samuels, Carmelo Scarpignato, Ellen M. Stein, Ronnie Fass, José María Remes‐Troches, Abraham Khan, Afrin Kamal Rahman, Kristle Lynch, Daniela Jodorkovsky, Marcelo F. Vela, Alexandra Vandenberg, Braden Kuo, Pelin Ergun, Sigh Pichamol Jirapinyo, Emanuele Asti, Salvatore Tolone, Eric G. Sheu, Renato Salvador, Marco Sozzi, Inna A. Husain, Justin C. Wu, Anthony Hobson, Nirmal S. Sharma, Wai‐Kit Lo, Daniel R. Duncan, C. Prakash Gyawali, Walter Chan, Daniel Sifrim, Edoardo Savarino, Nicola de Bortoli, Benjamin D. Rogers   +38 more
wiley   +1 more source

Positioning new pharmacotherapies for COPD

International Journal of COPD, 2015
Igor Z Barjaktarevic,1 Anthony F Arredondo,1 Christopher B Cooper1,2 1Department of Medicine, 2Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA Abstract: COPD imposes ...
Barjaktarevic IZ, Arredondo AF, Cooper CB   +2 more
doaj  

Muscarinic Receptor Agonists and Antagonists: Effects on Cancer [PDF]

, 2011
Many epithelial and endothelial cells express a cholinergic autocrine loop in which acetylcholine acts as a growth factor to stimulate cell growth. Cancers derived from these tissues similarly express a cholinergic autocrine loop and ACh secreted by the cancer or neighboring cells interacts with M3 muscarinic receptors expressed on the cancer cells to ...
openaire   +2 more sources

Pharmacological and neurophysiological aspects of space/motion sickness [PDF]

A motorized motion testing device modeled after a Ferris wheel was constructed to perform motion sickness tests on cats. Details of the testing are presented, and some of the topics covered include the following: xylazine-induced emesis; analysis of the ...
Crampton, George H., Lucot, James B.
core   +1 more source

Imposed expiratory resistance, dynamic hyperinflation and locomotor power and fatigue

Experimental Physiology, Volume 111, Issue 3, Page 809-819, 1 March 2026.
Abstract Expiratory flow limitation results in dynamic hyperinflation, dyspnoea and premature exercise intolerance. We aimed to measure whether expiratory resistance reduces locomotor power via limiting maximal voluntary motor activity, exacerbating muscle fatigue, or both.
Jonathan Cunha, Antoinette Domingo, Fred W. Kolkhorst, Harry B. Rossiter, Daniel T. Cannon   +4 more
wiley   +1 more source

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]

, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E, Mahoney, Jacob P, Manglik, Aashish, Sunahara, Roger K, Traynor, John R   +4 more
core