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Structural Determinants of Muscarinic Agonist Activity
1989 Traditionally, structure-activity relationships (SAR) among muscarinic cholinergic agonists have been derived from dose-effect studies on isolated tissues or in whole animals (Barlow, 1964). In general, in vitro assays are preferable to in vivo assays for studying relations between chemical structure and actual effect (pharmacodynamics).openaire +1 more sourceAgonist binding to multiple muscarinic receptors.
Federation proceedings, 1984 The binding of agonists to muscarinic cholinergic receptors is well described by a binding model of multiple affinity states (superhigh, high, and low) in most central and peripheral tissues. Although previous studies of the influences by divalent cations, guanine nucleotides, and sulfhydryl reagents support the concept that these regulators act ...T W, Vickroy, M, Watson, H I, Yamamura, W R, Roeske +3 moreopenaire +1 more sourceBis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity.
European journal of medicinal chemistry, 2014 C. Matera, L. Flammini, M. Quadri, Valentina Vivo, V. Ballabeni, U. Holzgrabe, K. Mohr, M. De Amici, E. Barocelli, S. Bertoni, C. Dallanoce +10 moresemanticscholar +1 more sourceMuscarinic Agonists
2010 Michael M. Morgan, MacDonald J. Christie, Thomas Steckler, Ben J. Harrison, Christos Pantelis, Christof Baltes, Thomas Mueggler, Markus Rudin, Lawrence H. Price, Malcolm Lader, R. H. Belmaker, Joseph H. Friedman, Peter Verhaert, Per Svenningsson, Per E. Andrén, Giovanni Hernandez, Peter Shizgal, Bart Ellenbroek, Trevor W. Robbins, Peter Verhaert, Per Svenningsson, Per E. Andrén, Paul Newhouse, Heather Wilkins, Lance R. McMahon, Luis Stinus, Stéphanie Caillé, Martine Cador, Mary E. Cain, Michael T. Bardo, Sarah Morgan, Angus Mackay, Lucio Tremolizzo, Gessica Sala, Carlo Ferrarese, Alfonso Abizaid, Shimon Amir, Alfonso Abizaid, Shimon Amir, Stephen M. Stahl, Meghan M. Grady, Theodora Duka, Rodrigo Andrade, Yesne Alici, William Breitbart, Debby Van Dam, Peter Paul De Deyn, Warren H. Meck, Catalin V. Buhusi, Malcolm Lader, Martine Cador, Marie-Louise G. Wadenberg, Tomek J. Banasikowski, Richard J. Beninger, Stefan Leucht, Kim Wolff, Peter Verhaert, Per Svenningsson, Per E. Andrén, Elizabeth C. Warburton, Anne M. Andrews, Greg A. Gerhardt, Lynette C. Daws, Johannes Mosbacher, Gabriele Fischer, Annemarie Unger, Martine Cador, Ian P. Stolerman, Seiya Miyamoto, Iain S. McGregor, Murray R. Thompson, Paul D. Callaghan, Trevor W. Robbins, Nachum Dafny, Bernard Le Foll, Theodora Duka, Albert Adell, Francesc Artigas, Anne M. Andrews, Greg A. Gerhardt, Lynette C. Daws, Roberto William Invernizzi, Ennio Esposito, Jelena Nesic, Theodora Duka, Yesne Alici, William Breitbart, Josef Marksteiner, Irene Adelt, Huaiyu Yang, George I. Papakostas, Malcolm Lader, Klaus A. Miczek, R. Hamish McAllister-Williams, Tomasz Schneider, Stephen B. Dunnett, Andrew Young, Klaus A. Miczek, Michael Minzenberg, W. Wolfgang Fleischhacker, Andrew Holt, Darrell D. Mousseau, Glen B. Baker, Stephen M. Stahl, Meghan M. Grady, Andreas Marneros, Guy M. Goodwin, Seiya Miyamoto, Mohammed Shoaib, Mitul A. Mehta, Seiya Miyamoto, Stephen C. Fowler, Joachim Liepert, Thomas R. E. Barnes, Christof Baltes, Thomas Mueggler, Markus Rudin, Ennio Esposito, Roberto William Invernizzi, Josee E. Leysen, Ben J. Harrison, Christos Pantelis, Ronald F. Mucha, Holden D. Brown, Michael E. Ragozzino, Michael E. Ragozzino, Holden D. Brown, Paul Newhouse, Heather Wilkins, R. Andrew Chambers +129 moreopenaire +1 more source
