Results 231 to 240 of about 386,471 (278)

Binding of agonists and antagonists to muscarinic receptors

Journal of Supramolecular Structure, 1976
AbstractThe binding of one irreversible and two reversible radioactive antagonists to muscarinic receptors in synaptosome preparations of rat cerebral cortex has been studied. The ligands all bind to the same receptor pool and directly and competitively yield self‐consistent binding constants closely similar to those obtained by pharmacological methods
Nigel J. M. Birdsall, Edward C. Hulme, Arnold S. V. Burgen, C. R. Hiley   +3 more
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Discriminative stimulus properties of muscarinic agonists

Psychopharmacology, 1987
In a two-lever, food-reinforced drug-discrimination paradigm separate groups of rats were trained to discriminate either arecoline, pilocarpine or oxotremorine from saline. The discriminative cues of all three agonists were potently blocked by scopolamine, but only by 30-60 fold higher doses of methylscopolamine.
G. T. Shearman, M. Jung, P. H. Kelly, Luis Artur Costa   +3 more
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Cross-tolerance between muscarinic agonists: Role of muscarinic receptors

Pharmacology Biochemistry and Behavior, 1987
In order to explore the relationship between response to muscarinic agonists and brain muscarinic receptors, two mouse strains that differ in acute sensitivity (DBA and C3H) were injected chronically with DFP or infused with oxotremorine. Chronic DFP-treated DBA mice were not tolerant to DFP's effects on any measure, but they were cross-tolerant to the
Laura J. Medhurst, Andrew Smolen, Toni Ness Smolen, Allan C. Collins   +3 more
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Muscarinic Agonists as Insecticides and Acaricides

Pesticide Science, 1997
A series of known agonists of the mammalian muscarinic receptor were prepared and evaluated for their insecticidal potential. It was discovered that pests such as Nilaparvata lugens (brown planthopper), Nephotettix cincticeps (green leafhopper), Tetranychus urticae (two-spotted spider mite) and Aphis gossypii (cotton aphid) were particularly sensitive ...
Nailah Orr, Michael R. Dick, James E. Dripps   +2 more
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Allosteric Modulators and Selective Agonists of Muscarinic Receptors

Journal of Molecular Neuroscience, 2006
Allosteric modulators of ligand-receptor interactions are found for a variety of receptors (Christopoulos, 2002). Allosteric agents attach to a binding site being topographically distinct from the site for conventional (orthosteric) agonists or antagonists.
U. HOLZGRABE, M. DE AMICI, K. MOHR
openaire   +4 more sources

M1 muscarinic agonists target major hallmarks of Alzheimer's disease--an update.

Current Alzheimer Research, 2007
UNLABELLED The M1 muscarinic receptor (M1 mAChR), preserved in Alzheimer's disease (AD), is a pivotal target that links major hallmarks of AD, e.g. cholinergic deficiency, cognitive dysfunctions, beta-amyloid (Abeta) and tau pathologies.
A. Fisher
semanticscholar   +1 more source

The utility of muscarinic agonists in the treatment of alzheimer’s disease [PDF]

Journal of Molecular Neuroscience, 2002
Alzheimer's disease is a progressive neurological disorder characterized by amyloid plaques and neurofibrillary tangles along with memory and cognitive deficits associated with a loss of basal forebrain cholinergic neurons. Efforts to treat Alzheimer's disease have focused on compounds that elevate cholinergic activity such as cholinesterase inhibitors
W. Messer
semanticscholar   +3 more sources

Muscarinic agonists in Alzheimer's disease

Life Sciences, 1997
As therapeutic agents, M1 agonists in the short-term may palliate symptoms of AD and improve memory function. In the long-term, M1 agonists have the potential to modify the underlying pathophysiology of AD, and thereby prevent or retard the course of dementia.
openaire   +3 more sources

Action of the muscarinic toxin MT7 on agonist-bound muscarinic M1 receptors.

European Journal of Pharmacology, 2004
The muscarinic toxin MT7 is the most selective ligand for the muscarinic M(1) receptors. Previous studies have shown that the toxin interacts with the antagonist-receptor complex and slows the antagonist dissociation rate, possibly by binding to an allosteric site and impeding the access to and egress from the orthosteric binding pocket. In the present
OLIANAS, MARIA CONCETTA, ADEM A, KARLSSON E, ONALI, PIER LUIGI   +3 more
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Molecular mechanics calculations on muscarinic agonists

Journal of Molecular Structure, 1990
Abstract Molecular mechanics calculations have been performed on the conformation freedom with respect to the torsion angles OCCN and COCC of acetylcholine, α( r -methylacetylcholine,β( s )-methylacetylcholine, α( r ),β( s )-diemthylacetylcholine and muscarine, in order to obtain information about the active conformation and its interaction with the ...
Jan Kroon, Huub Kooijman, Jan A. Kanters
openaire   +2 more sources