Results 181 to 190 of about 52,496 (299)

Risk of Hospitalized COVID‐19 in COPD: Single‐Inhaler Triple Versus Dual Bronchodilator Therapy

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 1, January 2026.
ABSTRACT Purpose Our objective was to estimate the effect of initiating an inhaled corticosteroids‐containing single‐inhaler triple agent (ICS‐LABA‐LAMA) compared with a single‐inhaler LABA‐LAMA dual bronchodilator in patients with COPD on the risk of severe COVID‐19 prior to the roll‐out of vaccines.
Simon Galmiche, Sophie Dell'Aniello, Samy Suissa   +2 more
wiley   +1 more source

Involvement of Ca2+ Signaling in the Synergistic Effects between Muscarinic Receptor Antagonists and β2-Adrenoceptor Agonists in Airway Smooth Muscle [PDF]

, 2016
Kentaro Fukunaga, Hiroaki Kume, Tetsuya Oguma, Wataru Shigemori, Yuji Tohda, Emiko Ogawa, Yasutaka Nakano   +6 more
openalex   +1 more source

Marked Reversibility of Functional Small Airway Disease Following Reduction of Hazardous Inhalational Exposure: A PRM CT Case Report

Respirology Case Reports, Volume 14, Issue 1, January 2026.
Serial parametric response mapping (PRM)‐computed tomography revealed dynamic changes in PRM‐functional small airway disease with occupational exposure, highlighting PRM's utility for detecting and monitoring small airway disease. ABSTRACT We report a case illustrating the role of parametric response mapping (PRM) in detecting and monitoring small ...
Yeun Ho Lee, Yunjoo Im, Sun Hye Shin, Ho Yun Lee, Hye Yun Park   +4 more
wiley   +1 more source

Critical evaluation of real‐world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract INTRODUCTION Repurposing Food and Drug Administration (FDA)‐approved drugs could accelerate treatment development for Alzheimer's disease (AD). METHODS Using the MarketScan claims database (2011 to 2020), we applied a trial emulation approach in two base cohorts: (1) individuals with mild cognitive impairment (MCI cohort) and (2) individuals ...
Reina Tonegawa‐Kuji, Ehud Karavani, Michael Danziger, Pengyue Zhang, Yuan Hou, Yadi Zhou, Marina Bykova, Andrew A. Pieper, Michal Rosen‐Zvi, Jeffrey Cummings, Feixiong Cheng   +10 more
wiley   +1 more source

Alcohol and the endocrine system: A critical review of disruptions, potential mechanisms, and health implications

Alcohol, Clinical and Experimental Research, Volume 50, Issue 1, January 2026.
The endocrine system coordinates whole body cellular function and maintains homeostasis. Alcohol impacts the integrity of endocrine regulation at multiple sites, contributing to risk for comorbidities. Some of the alcohol‐mediated pathophysiological effects on the endocrine system include alterations in receptor expression and responsiveness, protein ...
Patricia E. Molina, Liz Simon
wiley   +1 more source

Diphenylsulfone muscarinic antagonists: piperidine derivatives with high m2 selectivity and improved potency

, 2000
William Billard, Herbert Binch, Kristen Bratzler, Lian-Yong Chen, Gordon Crosby, Ruth A. Duffy, Sundeep Dugar, Jean E. Lachowicz, Robert McQuade, Pradeep Pushpavanam, Vilma Ruperto, Lisa A. Taylor, John W. Clader   +12 more
openalex   +1 more source

Natural History of Airway Hyperresponsiveness and Its Association With Asthma Traits

Allergy, Volume 81, Issue 1, Page 121-129, January 2026.
AHR improves in most children over adolescence when its relationship with asthma changes. AHR is better at ruling out asthma in children, while it is superior at ruling in asthma in young adults. Age should be considered when interpreting AHR, and different cutoffs might be required for children and adults.
Sophie Carra, Hongmei Zhang, Ramesh J. Kurukulaaratchy, Syed Hasan Arshad   +3 more
wiley   +1 more source

Ensifentrine Plus a Long-Acting Muscarinic Antagonist in COPD: A Trifunctional Dual Bronchodilation Perspective. [PDF]

Drugs
Cazzola M, Page CP, Calzetta L, Martinez FJ, Rogliani P, Matera MG.   +5 more
europepmc   +1 more source

The M1 Muscarinic Receptor Antagonist VU0255035 Delays the Development of Status Epilepticus after Organophosphate Exposure and Prevents Hyperexcitability in the Basolateral Amygdala [PDF]

, 2016
Steven L. Miller, Vassiliki Aroniadou‐Anderjaska, Volodymyr I. Pidoplichko, Taíza H. Figueiredo, James P. Apland, Jishnu K.S. Krishnan, Maria F. M. Braga   +6 more
openalex   +1 more source

Adiabatic-Bias Molecular Dynamics Simulations Reveal the Impact of Mutations on Muscarinic Antagonist Unbinding Kinetics. [PDF]

J Chem Inf Model
Coricello A, Chiaravalle AL, Musgaard M, Tehan BG, Elisi GM, Bottegoni G.   +5 more
europepmc   +1 more source