Results 181 to 190 of about 2,979 (198)

The new big is small: Leveraging knowledge from small trials for rare disease drug development: Blarcamesine for Rett syndrome

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 1049-1063, April 2025.
Big data in drug development may not satisfactorily address the demands of precision medicine in a rare disease population, making the use of smaller clinical trials necessary. Consequently, the use of innovative design and analysis of these clinical trials using model‐informed approaches have become indispensable.
Ene I. Ette, Emmanuel O. Fadiran, Christopher Missling, Edward Hammond   +3 more
wiley   +1 more source

Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma: A Systematic Review and Meta-analysis [PDF]

, 2018
Alan B. Goldsobel
openalex   +1 more source

Toll‐like receptor 4 deficiency ameliorates experimental ileitis and enteric neuropathy: Involvement of nitrergic and 5‐hydroxytryptaminergic neurotransmission

British Journal of Pharmacology, Volume 182, Issue 8, Page 1803-1822, April 2025.
Abstract Background and Purpose Inflammatory bowel disease (IBD) patients display genetic polymorphisms in toll‐like receptor 4 (TLR4) genes, contributing to dysregulate enteric nervous system (ENS) circuits with increased levels of 5‐HT and alteration of the neuroimmune crosstalk.
Sofia Faggin, Silvia Cerantola, Valentina Caputi, Angela Tietto, Elena Stocco, Annalisa Bosi, Alessandra Ponti, Antonella Bertazzo, Veronica Macchi, Andrea Porzionato, Edoardo V. Savarino, Cristina Giaroni, Maria Cecilia Giron   +12 more
wiley   +1 more source

Novel long‐acting antagonists of muscarinic ACh receptors [PDF]

, 2018
Alena Randáková, Vladimı́r Rudajev, Vladimı́r Doležal, John Boulos, Ján Jakubík   +4 more
openalex   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review

British Journal of Pharmacology, Volume 182, Issue 7, Page 1416-1445, April 2025.
Abstract In the past year, the European Medicines Agency (EMA), the Food and Drug Administration (FDA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) authorised 53 novel drugs. While the 2024 harvest is not as rich as in 2023, when 70 new chemical entities were approved, the number of ‘orphan’ drug authorisations in 2024 (21) is ...
Stavros Topouzis, Andreas Papapetropoulos, Steve P. H. Alexander, Miriam Cortese‐Krott, Dave A. Kendall, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Mauro M. Teixeira, Nathalie Vergnolle, Xin Wang, Péter Ferdinandy   +16 more
wiley   +1 more source

Characterization of the Molecular Mechanisms Underlying Lurasidone‐Induced Acute Manic Episodes in Bipolar Depression: A Network Pharmacology and Molecular Docking Approach

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
This study is the first to systematically explore the molecular mechanisms underlying lurasidone‐induced acute manic episodes in people with bipolar depression using network pharmacology and molecular docking approaches. Our bioinformatics and computational analyses demonstrated that lurasidone may regulate the serotonergic synapse signaling pathway by
Chao Li, Lei Yang, Qiuyu Zhang, Ying Zhang, Ranli Li, Feng Jia, Lina Wang, Xiaoyan Ma, Hongjun Tian, Chuanjun Zhuo   +9 more
wiley   +1 more source

Layer‐Specific Connectivity and Functional Interference of Chrna2+ Layer 5 Martinotti Cells in the Primary Motor Cortex

European Journal of Neuroscience, Volume 61, Issue 7, April 2025.
Chrna2+ Martinotti cells (Mα2cells) in the primary motor cortex (M1) receive monosynaptic long‐range inputs from secondary motor cortex (M2), primary somatosensory cortex (S1), ventral anterolateral complex of the thalamus (VAL), globus pallidus externa (GPe), and substantia innominata (SI).
Anna Velica, Katharina Henriksson, Thawann Malfatti, Barbara Ciralli, Ingrid Nogueira, Evridiki Asimakidou, Klas Kullander   +6 more
wiley   +1 more source

European Academy of Neurology (EAN)/European Federation of Autonomic Societies (EFAS)/International Neuro‐Urology Society (INUS) Guidelines for Practising Neurologists on the Assessment and Treatment of Neurogenic Urinary and Sexual Symptoms (NEUROGED Guidelines)

European Journal of Neurology, Volume 32, Issue 4, April 2025.
ABSTRACT Background Urinary and sexual symptoms are common following neurological disease, and we aimed to develop multidisciplinary inter‐society evidence‐based management guidelines. Methods The ADAPTE framework was used, and a systematic search of guidelines published in different languages was performed.
Jalesh N. Panicker, Alessandra Fanciulli, Magdalena Krbot Skoric, Tamara Kaplan, Katina Aleksovska, Ivan Adamec, Marcio Augusto Averbeck, Nicole Campese, Pietro Guaraldi, Fabian Leys, Jorge Moreno‐Palacios, Sara Simeoni, Iva Stankovic, Sarah Wright, Amit Batla, Bertil Blok, Claire Hentzen, Max Josef Hilz, Thomas M. Kessler, Helmut Madersbacher, Kannan Rajasekharan Nair, Krishnan Padmakumari Sivaraman Nair, Mahreen Pakzad, Anne Pavy‐Le Traon, Guy Peryer, Mikolaj Przydacz, Ryuji Sakakibara, Udit Saraf, Matthew Smith, Walter Struhal, Roland D. Thijs, Katarina Ivana Tudor, Marcin Tutaj, David B. Vodušek, Gregor Wenning, Mario Habek   +35 more
wiley   +1 more source

Acute and persistent changes in neural oscillatory activity predict development of epilepsy following acute organophosphate intoxication in adult rats

Epilepsia, Volume 66, Issue 4, Page 1329-1342, April 2025.
Abstract Objective Acute organophosphate (OP) intoxication affects a significant number of individuals worldwide. Those who survive OP‐induced cholinergic crisis, which includes status epilepticus, often develop neurological morbidities. Here, we provide a rigorous characterization of the acute and delayed electrophysiological responses to OP ...
Jeremy A. MacMahon, Peter M. Andrew, Ali Izadi, Donald A. Bruun, Naomi H. Saito, Daniel J. Tancredi, Amy Brooks‐Kayal, Pamela J. Lein, Gene G. Gurkoff   +8 more
wiley   +1 more source

Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism

The FEBS Journal, Volume 292, Issue 8, Page 2017-2050, April 2025.
SUCNR1, activated by succinate, is a Gi‐ and Gq‐coupled receptor present at the plasma membrane and in endosomes. There are conflicting reports about the pro‐/anti‐inflammatory effects of the succinate‐SUCNR1 signaling axis, and these are likely due to localization‐dependent signaling.
Aenne‐Dorothea Liebing, Philipp Rabe, Petra Krumbholz, Christian Zieschang, Franziska Bischof, Angela Schulz, Susan Billig, Claudia Birkemeyer, Thanigaimalai Pillaiyar, Mikel Garcia‐Marcos, Robert Kraft, Claudia Stäubert   +11 more
wiley   +1 more source